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npj Vaccines
Scopus
ISSN 2059-0105 · Nature Portfolio · 1.275 artikel di indeks
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Artikel Jurnal
A single-cycle recombinant VSV vaccine displaying the Hendra virus glycoprotein uniformly protects against Hendra and Nipah virus challenge
Abstract Hendra (HeV) and Nipah (NiV) are closely related, highly pathogenic paramyxoviruses which cause severe, often fatal disease in humans and animals. There are no approved vaccines to protect humans from HeV or NiV infection, although an ideal vaccine countermeasure should provide a…
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Immunogenicity and protection of octavalent influenza vaccine candidates using adjuvanted proteins or mRNA-LNPs in naïve mice
Abstract Currently used influenza vaccines primarily induce antibody responses against hemagglutinin (HA). Neuraminidase (NA) has been proposed as a complementary antigen to improve and potentially expand the breadth of influenza vaccine protection. Here, we assessed the immunogenicity and…
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Recombinant vaccinia vectored ASFV vaccine enhances swine survival against genotype II challenge
Abstract The African Swine Fever Virus (ASFV) poses a major threat to global livestock production by infecting both domestic and wild pigs, causing significant economic loss. Despite promising protective results observed with live attenuated viruses, the safety concern blocked its extensive…
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Functional antibody signatures following therapeutic immunization in Simian and Human immunodeficiency virus infection
Abstract Reducing the latent HIV-1 reservoir is essential to achieving a functional cure, and therapeutic vaccination is a promising strategy. While most approaches emphasize cytotoxic CD8⁺ T-cell responses, the role of antibodies—particularly Fc-mediated effector functions—remains incompletely…
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Artikel Jurnal
Development of pre-pandemic influenza candidate vaccine viruses for use in vaccine manufacturing
Abstract Influenza A viruses continually pose pandemic threats, underscoring the need for timely development of Candidate Vaccine Viruses (CVVs) that meet regulatory expectations for vaccine manufacturing. This protocol describes the procedures used at CDC to generate recombinant CVVs through…
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Intranasal S-2P and lentinan formulation confers broad protection against SARS-CoV-2 VOCs via IFN-γ-dominant mechanisms
Abstract Effective respiratory mucosal vaccines remain urgently needed to mitigate the rapid mutation and transmission of SARS-CoV-2. Here, we demonstrated that the spike protein (S-2P) of ancestral SARS-CoV-2 acted as a self-adjuvanted antigen for intranasal immunization, inducing robust systemic…
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Artikel Jurnal
Refined phenotyping of vaccine responses reveals transcriptomic determinants of neutralizing antibody heterogeneity
Abstract Individuals exhibit considerable heterogeneity in vaccine-induced antibody responses, yet commonly used binary classifications may overlook intermediate patterns. More nuanced grouping could better capture inter-individual differences. Here, we analyzed longitudinal neutralizing antibody…
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Passive transfer of human sera from chikungunya virus virus-like particle vaccine (Vimkunya) recipients fully protects non-human primates from viremia
Abstract Vimkunya, a chikungunya virus (CHIKV) virus-like particle (VLP) vaccine, is well-tolerated and induces a rapid, durable serum neutralizing antibody (SNA) response in individuals aged ≥12 years. This study evaluated the efficacy of human CHIKV VLP antisera to protect cynomolgus macaques…
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Immune checkpoint-engineered virus-like particles induce antigen-specific immune tolerance and protect against food allergy
Abstract Recent advances in our understanding of immune tolerance, particularly the role of immune checkpoints in peripheral tolerance, have opened promising new avenues for therapeutic interventions in immune-related disorders. In this study, we developed a novel class of tolerogenic vaccines…
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Type I interferon restricts mRNA vaccine efficacy through suppression of antigen uptake in cDCs
Abstract Type I interferons (IFN) are key mediators of innate immune activation, promoting upregulation of costimulatory molecules and Major Histocompatibility Complex (MHC) I/II on antigen-presenting cells (APCs). However, IFN also suppress endogenous translation to restrict viral replication…
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Artikel Jurnal
Breaking barriers in prostate cancer: the mRNA vaccine breakthrough and what comes next
Abstract Prostate cancer (PC) treatment is evolving beyond conventional therapies. This review explores mRNA-based vaccines as a promising immunotherapy. We discuss their mechanism of action, advantages in production and safety, and results from early clinical trials (e.g., CV9103/4). Key…
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Development of a J paramyxovirus-based vaccine vector
Abstract J paramyxovirus (JPV) is a non-segmented, negative-strand RNA virus in the Jeilongvirus genus of the Paramyxoviridae family. Recently, a recombinant JPV lacking the small hydrophobic protein (SH) gene (rJPV-∆SH) has been used as a viral vector for avian influenza virus H5N1 and HIV vaccine…
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Artikel Jurnal
An mRNA influenza vaccine induces immunity comparable to an adjuvanted vaccine in a randomized trial
Abstract Influenza causes substantial morbidity and mortality worldwide. This randomized, open-label, phase 1 trial (ClinicalTrials.gov, NCT05397223, date of registration: May 31, 2022) compared the immunogenicity of an mRNA-based quadrivalent influenza hemagglutinin (HA) vaccine (mRNA-1010) with a…
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Artikel Jurnal
Safety, immunogenicity, and baseline immune correlates of vaccine JNJ-0535 in participants with or without CHB
Abstract The role of T-cell-mediated immune responses is recognized as pivotal in achieving functional cure in chronic hepatitis B (CHB) patients. We aimed to assess safety and T-cell responses induced by JNJ-6430535 (JNJ-0535); a hepatitis B virus (HBV)-specific therapeutic DNA vaccine…
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Novel recombinant H5-based vaccine provides effective protection against H5N1 influenza virus in cats
Abstract The emergence and broad circulation of highly pathogenic avian influenza (HPAI) H5N1 virus in wild birds and its spillover into dairy cows with sustained transmission in this species pose a major risk to felines, which are highly susceptible and often succumb to the infection. Here, we…
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Artikel Jurnal
Live-attenuated foot-and-mouth disease virus vaccine engineered by codon deoptimization induces a strong protective immune response in cattle
Abstract Foot-and-mouth disease (FMD) is a fast-spreading, economically devastating veterinary viral disease. While inactivated vaccines have contributed to FMD control worldwide, recent outbreaks in Europe and Asia highlight the need for new control strategies. Live-attenuated virus (LAV) vaccines…
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Artikel Jurnal
Field vaccination against CCHFV and Hyalomma tick infestation reduces multiple tick-borne infections in sheep
Abstract Tick-borne pathogens (TBPs) are expanding globally, with their impact on public health expected to rise due to climate change. Immunizing livestock offers a cost-effective alternative or adjunct to human vaccination. We evaluated two DNA vaccines, one targeting Crimean-Congo hemorrhagic…
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