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Tungs’ Medical Journal
ISSN 2071-3592 · Wolters Kluwer Medknow Publications · 117 artikel di indeks
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A cross-sectional study: Cognitive dysfunction and depression among older residents in central Taiwan communities
Abstract Background: Cognitive dysfunction and depressive tendencies often add to the caregiving burden and frustration experienced by family members. Objectives: This study aimed to explore the factors influencing cognitive function and depression among community-dwelling older adults. Identifying…
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Comparative analysis of robotic-assisted and conventional laparoscopic ureterolithotomy: A single-center retrospective study
Abstract Background: Robotic-assisted laparoscopic ureterolithotomy (LU) (RALU) has been proposed as an alternative to conventional LU for managing complex ureteral stones. However, direct comparative evidence on clinical outcomes remains limited. Objectives: This study aimed to directly compare…
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Artikel Jurnal
A retrospective study of factors affecting the severity of dementia in patients
Abstract Background: Currently, Taiwan has entered a super-aged society. Therefore, the number of people suffering from dementia and the social burden are expected to increase. Moreover, effectively reducing the risk factors for dementia and preventing and detecting its occurrence at an early stage…
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Colchicine and cardiovascular diseases: A narrative review
Abstract Colchicine was initially an anti-inflammatory drug used to treat gout and cardiovascular diseases and alleviate acute pain by inhibiting the immune response. Despite being an old drug, it has found a new purpose because it was recently approved by the US Food and Drug Administration for…
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Gestational diabetes mellitus and associated risk factors in a rural block of Sonepat District, Haryana, India: A cross-sectional study
Abstract Background: Gestational diabetes mellitus (GDM) presents a significant health challenge impacting one in six expectant mothers worldwide. GDM can cause life-threatening complications for both mother and child. As GDM is preventable, recognizing its prevalence and risk factors as early as…
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Periodontal disease and dementia risk: A narrative review of population-based evidence and modifiable interventions
Abstract Dementia affects over 50 million people worldwide and is projected to triple by 2050. Chronic inflammation and microbial dysbiosis, including periodontal disease, may contribute to neurodegenerative disease development. We reviewed eight population-based studies from Taiwan…
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Classical wisdom and modern science: Traditional Chinese Medicine compounds in the treatment of psoriasis – A narrative review
Abstract Psoriasis is a chronic immune-mediated skin disorder characterized by aberrant T cell activation, keratinocyte hyperproliferation, and persistent inflammation. Although biologic therapies targeting key cytokines, such as interleukin (IL)-17A and IL-23, have improved disease management…
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Artikel Jurnal
DNM1L as a prognostic biomarker and therapeutic target in breast cancer: A multi-omics analysis and In vitro validation
Abstract Background: Breast cancer is the most commonly diagnosed cancer and the leading cause of tumor-related death in women. Although the role of the Dynamin 1-like (DNM1L) gene in mitochondrial dynamics is well established, its clinical relevance and molecular mechanisms in breast cancer remain…
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The role of the ESR1 gene in breast cancer: A comprehensive review of detailed analysis of biology, mutational landscapes, pathways, and therapeutic implications
Abstract The estrogen receptor alpha (ERα) protein, which is encoded by the ESR1 gene, is a key molecular factor that defines breast cancer. ERα activity regulates a complex program of hormonal activation and survival. ERα hypersensitivity, whether due to increased expression, activation, or…
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High Tudor and KH domain-containing protein expression predicts poor prognosis and drug response in uterine corpus endometrial carcinoma: Insights from TCGA and GEO analyses
Abstract Background: Uterine corpus endometrial carcinoma (UCEC) is a common gynecologic malignancy; however, its molecular underpinnings remain incompletely defined. Recent studies have suggested that roles played by mitochondrial and RNA-processing proteins in cancer progression remain unknown…
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High-altitude pulmonary edema in an experienced climber: A case report
High-altitude pulmonary edema (HAPE) is a life-threatening altitude illness that usually occurs in insufficiently acclimatized climbers at altitudes above 2500 m. HAPE also accounts for the high-altitude-related mortality among all high-altitude sicknesses. The risk of developing HAPE increases…
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Clinical applications of whole-genome and whole-exome sequencing in medical practice: Current status, challenges, and future directions – A narrative review
Whole-genome sequencing (WGS) and whole-exome sequencing (WES) are transformative next-generation sequencing (NGS) technologies that have rapidly revolutionized clinical diagnostics, particularly in cases of rare genetic disorders and oncology. WGS provides comprehensive data by covering the entire…
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Factors associated with local recurrence in patients with oral cancer: A retrospective study from a regional teaching hospital in Central Taiwan
Background: Cancer remains the leading cause of death in Taiwan, with oral cancer ranking among the top 3 cancers in men. Oral cancer is characterized by a high recurrence rate, with most cases occurring within 3 years. Approximately 80% of recurrences are local, occurring at the primary site…
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A look into atrophic gastritis: A narrative review
Atrophic gastritis represents a prevalent chronic condition affecting the digestive system. It is characterized by the progressive atrophy of the stomach’s glandular and parietal cells, which are subsequently replaced by connective tissue, distinguishing it from acute gastritis. Nonspecific…
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A rare pediatric renal abscess caused by Salmonella in a healthy infant: A case report and literature review
Renal abscesses in children are rare, while those caused by Salmonella species are particularly uncommon in infants without underlying risk factors. This study aimed to report a case of a previously healthy 1-year- and 2-month-old boy who presented with persistent fever despite negative urinalysis…
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Incidental identification of a multilocular cystic renal neoplasm of low malignant potential: A rare case report
Multilocular cystic renal neoplasms of low malignant potential (MCRNLMP), which account for
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New insights into the treatment of hyperlipidemia: An expert review
The treatment of hyperlipidemia has been established to reduce the development and progression of atheroma and thereby reduce atherosclerotic cardiovascular disease events. Low-density lipoprotein cholesterol (LDL-C) is the primary target for treatment, and the LDL-C treatment goals should be…
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STAMBP as a potential contributor of docetaxel resistance and prognostic biomarker in breast cancer
Background: Breast cancer continues to be a leading cause of cancer-related mortality among women worldwide, with resistance to docetaxel posing a major therapeutic challenge. STAMBP, a deubiquitinating enzyme from the JAMM family, plays a key role in maintaining proteostasis through ubiquitin…
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Exploring the impact of quality of life and dialysis duration on sleep quality among patients undergoing hemodialysis in Taiwan: A cross-sectional study
Background: As the population ages, the prevalence of chronic disease—and consequently, end-stage renal disease (ESRD)—has increased. Sleep quality is crucial for maintaining kidney function. While previous research has primarily examined the impact of poor sleep on quality of life, fewer studies…
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Artikel Jurnal
Melena as the first sign of multifocal small bowel gastrointestinal stromal tumors in a patient with neurofibromatosis type 1: A case report
A 64-year-old man with neurofibromatosis type 1 (NF1) presented with melena and anemia. Initial endoscopy findings were inconclusive. Computed tomography and enteroscopy revealed active bleeding from a duodenal lesion. Laparotomy identified a bleeding duodenal tumor and multiple small bowel tumors…