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Journal of Functional Biomaterials
Scopus
ISSN 2079-4983 · MDPI AG · 2.759 artikel di indeks
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Construction of an In Vitro Blood–Brain Barrier Micro-Organoid Model Using Decellularized Squid Mantle Scaffold Film
Although blood–brain barrier (BBB) models are of great value in investigating neurological diseases, the structural complexity and intricate function based on cell–cell interactions of the BBB bring various limitations to the applications of existing models. In this study, a novel BBB…
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Phthalimidoperoxycaproic Acid (PAP) Versus Peroxides and Impact on Dental Enamel After Whitening Treatment: An In Vitro Study
Phthalimidoperoxycaproic acid (PAP) emerges as a promising alternative non-peroxide bleaching agent to hydrogen peroxide (HP), offering similar efficacy with potentially less enamel damage. This in vitro study aimed to evaluate and compare the effects of 37.5% HP, 35% carbamide peroxide (CP), and…
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Irradiation Enhances the Biomedical Functional Characteristics of Collagen Sponges: A Potential Strategy for Medical Collagen Sponge Modification
Developing safe and effective hemostatic materials is critical for rapid bleeding control and wound management. However, traditional hemostatic materials using chemical crosslinking often fall short in hemostatic efficiency and carry risks of secondary injury from reagent residues. This study…
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Oxidative Stress, Pro-Inflammatory Response, Cytotoxicity and Apoptosis Induced by Contemporary Endodontic Sealers in Human Periodontal Ligament Fibroblasts
The biological compatibility of endodontic sealers is a key determinant of periapical tissue healing. This in vitro study investigated the cytotoxic, pro-inflammatory, and redox-related effects of eight endodontic sealers on human periodontal ligament fibroblasts (HPdLFs): Biopulp…
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Application of Fibrin-Laminin Hydrogel Concurrent with Electrically Stimulated Eccentric Training Hinders Recovery in Volumetric Muscle Loss
Regenerative rehabilitation can enhance skeletal muscle recovery following trauma-induced volumetric muscle loss (VML). We previously optimized fibrin-laminin hydrogels for muscle regeneration and an electrically stimulated eccentric contraction training (EST) for muscle rehabilitation. The goal of…
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One-Year Clinical Performance of Injectable and Paste-Type Composite Resins in Non-Carious Cervical Lesions Prepared with Er,Cr:YSGG Laser and Acid Etching: A Randomized Clinical Trial
Background/Objectives: Non-carious cervical lesions (NCCLs) are common defects in adults that can lead to dentin hypersensitivity and aesthetic concerns, for which composite resin restorations currently represent the gold standard of care. However, evidence regarding the long-term clinical…
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Dental Implantation Changes the Bone Morphology and Mineral Density of Human Mandibular Condyle: A Pilot Study
Dental implantation affects masticatory bite and muscle forces. The temporomandibular joint (TMJ) bears a substantial amount of these masticatory forces. Thus, the objective of the current study was to investigate whether dental implantation alters the human mandibular condyle. Among 556 images, 54…
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Structure–Property–Function Evaluation of a β-Type Ti-Nb-Zr Alloy for Dental Implant Applications with Short-Term Clinical Validation
Titanium-based alloys are widely used in dental implantology; however, the mechanical limitations of commercially pure titanium (cpTi) and unresolved concerns regarding stress shielding remain. This study evaluated the structure–property–function relationship of a novel β-type…
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Fibroblast-Derived ECM as a Donor-Specific Pro-Osteogenic Coating Surpassing ASC- and Osteoblast-Derived ECM
Large bone defects remain a major clinical challenge, as current treatments primarily provide mechanical stability while often insufficiently addressing the biological microenvironment. The cell-deposited extracellular matrix (CD-ECM) represents a promising strategy to improve implant bioactivity…
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Biocompatible Electrospun Biomaterials for Advancing Thermoregulating Wearable Sensors in Next-Generation Smart Textiles
The rapid growth of electronic devices, including wearable sensors, has increased electronic waste, driving interest in sustainable, biocompatible materials. Electrospun biomaterials have emerged as versatile substrates for multifunctional wearable textiles, offering flexibility, high surface area…
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Effects of Provisional Cement Cleaning Methods on Resin–Dentin Bond Strength Following Immediate Dentin Sealing with Different Adhesive Systems
This study evaluated the effects of different provisional luting cement removal methods on the shear bond strength (SBS) of resin cement to dentin following immediate dentin sealing (IDS) performed with two adhesive systems. A total of 168 extracted, caries-free human third molars were used, of…
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Parameter Optimisation in 3D Extrusion Printing of Polyhydroxybutyrate Using Design of Experiment Methodology
This study systematically optimised extrusion-printing parameters for polyhydroxybutyrate (PHB) using a Design of Experiment (DoE) approach to improve printability and construct fidelity. A five-factor DoE was conducted to evaluate the individual and interactive effects of printhead temperature…
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Plasma-Coated Collagen Membranes Gain Barrier Function Through Heat Treatment
Guided bone regeneration (GBR) relies on barrier membrane integrity to prevent soft-tissue ingrowth. Although collagen membranes are widely used, their limited longevity can compromise space maintenance, underscoring the need for strategies that enhance membrane stability without impairing the…
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Evaluation of Clinical Performance of Alkasite Restorative Materials: A Systematic Review and Meta-Analysis
Ion-releasing restorative biomaterials have gained increasing attention in minimally invasive dentistry due to their potential to combine mechanical reliability with therapeutic functionality. Cention® N is an alkasite-based restorative material designed to release fluoride, calcium, and hydroxyl…
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Advanced Technologies for Processing Functional Biomaterials
Biomaterial processing is a crucial operation that involves mechanical and chemical treatments to transform a source material into a biocompatible and bioactive product tailored to a specific medical application [...]
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Collagen-Based Delivery Systems for the Prevention of Alveolitis: A Narrative Review and Rationale for Biopharmaceutical Development Requirements
Alveolitis remains a common postoperative complication following tooth extraction, characterized by inflammation and delayed socket healing. Collagen-based materials have shown promise in promoting tissue regeneration and reducing inflammation. This review evaluates the efficacy of collagen in the…
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Self-Assembled Nanoparticles with Kynureninase-Fc Fusion Protein and Pheophorbide A for Photodynamic Immunometabolic Cancer Therapy
Background/Objectives: Aberrant metabolism in tumors exacerbates the immunosuppressive tumor microenvironment. The immunosuppressive metabolite kynurenine inhibits the activation of effector T cells. Current antitumor drugs targeting kynurenine focus on small molecule inhibitors, which exhibit…
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Antibacterial and Bioregenerative Nanomaterials in Oral Health: From Material Design to Clinical Translation and Technological Trends
Context: The increasing incidence of secondary caries and the failure of restorations have intensified research into dental restorative materials capable of actively interacting with the oral environment. In this context, antibacterial and bioregenerative nanomaterials have attracted growing…
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Efficiency of Orthodontic Adhesives: Influence of Saliva and Shear Direction—In Vitro Study
This in vitro study evaluated the shear bond strength (SBS) and adhesive remnant index (ARI) of orthodontic molar tubes bonded using conventional, hydrophilic, and self-etch adhesives under dry and saliva-contaminated conditions, while also assessing the impact of shear force direction. Extracted…
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Comparing Two Surgical Approaches Using Cross-Linked Hyaluronic Acid-Biofunctionalized Alloplast Particulate in Sinus Floor Elevation: A Randomized Clinical Trial
Objective: The purpose of this study was to assess the outcome of sinus grafting with a beta-tricalcium phosphate/hydroxyapatite (ß-TCP/HA) alloplast particulate biofunctionalized with cross-linked hyaluronic acid (xHya), comparing two surgical access techniques. Clinical, histological…
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