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Indonesian Biomedical Journal
Scopus
ISSN 2085-3297 · Secretariat of The Indonesian Biomedical Journal · 643 artikel di indeks
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Artikel Jurnal
Collagen Restoration from Combined Radiofrequency Microneedling and Polydioxanone Filler in Oxidative Stress-Mediated Skin Aging
BACKGROUND: Oxidative stress plays a central role in skin aging by promoting reactive oxygen species–mediated collagen degradation, fibroblast senescence, and dermal thinning. Although radiofrequency microneedling (RFM) and polydioxanone (PDO) filler individually stimulate collagen remodeling…
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Artikel Jurnal
In silico–guided Design and Endonuclease-Based Functional Validation of sgRNAs Targeting ERBB2 Transmembrane and Kinase Domains
BACKGROUND: Erythroblastic oncogene B2 (ERBB2) overexpression promotes breast cancer progression through activation of phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and mitogen-activated protein kinase (MAPK) signaling pathways. Although CRISPR–Cas9 enables precise gene disruption…
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Artikel Jurnal
Alnustone and Curcumin from Curcuma xanthorrhiza Roxb. as Potential Multi-Target Anti-Inflammatory Adjuvants in Pulpitis: An in silico Molecular Docking Study
BACKGROUND: Pulpitis is an inflammatory disorder of the dental pulp driven by activation of the toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88)/interleukin-1 receptor-associated kinase 1 (IRAK-1)/tumor necrosis factor (TNF) receptor-associated factor 6…
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Artikel Jurnal
Elevated TLR4 as Potential Biomarker for RMT-positive Subclinical Tuberculosis
BACKGROUND: Subclinical tuberculosis (TB) is often underdiagnosed due to the limited sensitivity of sputum-based diagnostics. Host-response biomarkers, particularly pattern recognition receptors (PRRs), offer a potential alternative. Toll-like receptor 4 (TLR4), scavenger receptor class B type 1…
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Artikel Jurnal
Vitamin D and Magnesium Combination Lowers High-Sensitivity C-Reactive Protein, Interleukin-12, Renin, and Carotid Vessel in Diabetic Rats
BACKGROUND: Diabetes mellitus induces oxidative stress, inflammation, and endothelial dysfunction, accelerating atherosclerosis development marked by elevated high-sensitivity C-reactive protein (hs-CRP) and interleukin-12 (IL-12). Diabetes often causes significant vascular changes, which can be…
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Artikel Jurnal
Mahkota Dewa (Phaleria macrocarpa) Fruit Extract Decrease Malondialdehyde, Tumor Necrosis Factor-α, and Caspase 3 Levels May Improve Infertility in Endometriosis Mice
BACKGROUND: Endometriosis, which often causes infertility, is characterized by a complex interplay between oxidative stress, inflammatory response, and apoptosis. Currently, the most effective therapy used for endometriosis is hormonal treatments, however it has many common side effects. Therefore…
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Artikel Jurnal
Elevated Progestin-Related Immunoreactivity is Positively Associated with Bleeding Severity in Women with Intramural Uterine Fibroids
BACKGROUND: Uterine fibroids is an intentional cause of recurrent uterus bleeding. As a synthetic progestin, medroxyprogesterone acetate (MPA) is sequentially used as a medication for extensive uterine bleeding and have been broadly studied in gynecological field research. However, its role as a…
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Artikel Jurnal
The Role of PCSK9 Inhibition and Small Interference RNA (siRNA) in The Management of Dyslipidaemia and ASCVD
Compelling evidence linking low-density lipoprotein cholesterol (LDL-C) reduction to decreased mortality has positioned LDL-C lowering as a central strategy in the prevention of atherosclerotic cardiovascular disease (ASCVD). Nonetheless, despite widespread statin use, an estimated 10–20% of…
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Artikel Jurnal
The Impact of Organoid to Assembloid Technology in Biomedical Research
Organoids, three-dimensional, self-organized structures derived from pluripotent or adult stem cells, have revolutionized biomedical research by overcoming the inherent limitations of traditional 2D cultures and animal models. This review traces the evolution of organoid technology from initial…
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Artikel Jurnal
Chrono-Resistance Training Optimizes Hippocampal Oxidative Balance, Reduces Visceral Fat, and Enhances Memory in Healthy Rats Model: Preliminary Findings
BACKGROUND: Exercise acts as a non-photic zeitgeber and reduces visceral adiposity, a key source of oxidative stress that impairs hippocampal integrity and cognitive function. Excess visceral fat promotes systemic redox imbalance, compromising hippocampal-dependent spatial memory. Early oxidative…
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Artikel Jurnal
Elevated D-dimer is Associated with Anemia, Immune Dysregulation, and Hepatic–Renal Dysfunction in Acute Burn Patients
BACKGROUND: Burn injury induced increased risk of venous thromboembolism (VTE) due to hypercoagulability, immobilization, and endothelial injury. Despite this risk, VTE in burn patients often remains clinically undetected. Although D-dimer is widely used as a VTE marker, its utility in burn…
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Artikel Jurnal
Ternary Solid Dispersion Improves Anti-cancer Activity of Alpha-mangostin Against MCF-7 Breast Cancer Cells
BACKGROUND: Alpha-mangostin (AM) exhibits potent anti-breast cancer activity but its therapeutic effectiveness is constrained due to low aqueous solubility and poor bioavailability. Ternary solid dispersions (TSDs) were developed by adding another excipient to address these challenges…
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Artikel Jurnal
Combined COX-2 and HER-2 Biomarker Profiling to Predict Neoadjuvant Chemoradiotherapy Response in Locally Advanced Rectal Cancer
BACKGROUND: Locally advanced rectal cancer (LARC) is commonly treated with neoadjuvant chemoradiotherapy (nCRT), but highly variable response limits outcomes and highlights the need for predictive biomarkers. Cyclooxygenase-2 (COX‑2) and human epidermal growth factor receptor 2 (HER‑2) are…
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Artikel Jurnal
Promoter Methylation and Low Placental Expression of Metalloproteinase (MMP)-9, Human Leukocyte Antigen (HLA)-G, Vascular Endothelial Growth Factor (VEGF), and Highly Soluble Endoglin (sEng) as Risk Factors for Preeclampsia
BACKGROUND: Dysregulated expressions of metalloproteinase (MMP)-9, human leucocyte antigen (HLA)-G, vascular endothelial growth factor (VEGF), and soluble endoglin (sEng) reflect impaired angiogenesis, immune tolerance, endothelial function, and trophoblast invasion that characterize abnormal…
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Artikel Jurnal
Epstein–Barr Virus Latent Membrane Protein-1 (EBV LMP-1) in Nasopharyngeal Carcinoma: Immune Correlates and Potential as A Clinical Outcome Biomarker
In endemic populations, nasopharyngeal carcinoma (NPC) is associated with epstein-barr virus (EBV) infection, with latent membrane-1 (LMP-1) playing a major role as an oncoprotein. Despite this well-established biological role, the clinical use of LMP-1 remains limited; therefore this review aimed…
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Artikel Jurnal
Soursop Leaf Extract Reduces AST, ALT, Bilirubin Levels, and Liver Damage Scores in Sorafenib-treated Wistar Rats with Hepatocellular Carcinoma
BACKGROUND: Sorafenib, the standard therapeutic agent for advanced hepatocellular carcinoma (HCC), may induce hepatic dysfunction, thereby necessitating adjunctive therapy to mitigate this adverse effect. While preliminary research has suggested that Soursop (Annona muricata) leaves exhibit…
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Artikel Jurnal
Autologous Dendritic Cell Immunotherapy Modulates Renal Perfusion and Hemodynamics in Diabetic Kidney
BACKGROUND: Diabetic kidney disease (DKD) is driven by chronic inflammation and endothelial dysfunction, which often persist despite standard pharmacological treatments. Autologous dendritic cell (DC) immunotherapy offers a novel approach to restore immune homeostasis and improve renal vascular…
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Artikel Jurnal
Aqueous and n-Hexane Fractions of Eruca sativa Differentially Target Glycemic Control and Pancreatic Islet Protection in Diabetic Rats
BACKGROUND: The search for novel antidiabetic agents that simultaneously lower blood glucose and protect pancreatic β-cells is crucial. While Eruca sativa is known for its antidiabetic properties, the specific contribution of its solvent fractions to different therapeutic targets remains poorly…
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Artikel Jurnal
Placental LEP Promoter Hypomethylation is Associated with Increased Leptin and Umbilical Artery Vascular Resistance in Maternal Obesity
BACKGROUND: Maternal obesity has been associated with altered fetal development involving metabolic, hormonal, vascular, and epigenetic processes. The leptin (LEP) gene is crucial for placental angiogenesis and fetal growth. However, evidence linking placental LEP promoter methylation status with…
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Artikel Jurnal
Combined Vitamin D and Magnesium Supplementation Improves Insulin, HOMA Indices, Blood Glucose, and Oxidative Stress Markers in Diabetic Rats
BACKGROUND: Diabetes mellitus (DM) is characterized by disturbances in glucose homeostasis, chronic low-grade inflammation, and heightened oxidative stress. Alterations in vitamin D status and magnesium homeostasis are frequently observed in DM and have been implicated in impaired insulin…