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Pharmaciana
ISSN 2088-4559 · Universitas Ahmad Dahlan · 529 articles in the index
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Journal Article
Antibacterial activity of purified papaya leaf (Carica papaya L.) fraction emulgel as anti-acne against Staphylococcus aureus
Acne (acne vulgaris) is a skin disorder caused by Staphylococcus aureus. Continuous antibiotic use for acne management was reported to cause resistance, so alternative treatments using natural ingredients were needed. Papaya leaves can be formulated into dosage forms to facilitate their use. This…
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Journal Article
The effect of reducing blood sugar levels from Stichopus hermanii on alloxan-induced rats
Stichopus hermanii, or gold sea cucumber, is a marine organism that can be utilized for the treatment of diabetes mellitus. The relationship between observed biological activities and the responsible bioactive compounds is influenced by the solvent used during extraction. The compounds in gold sea…
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Journal Article
An Cost-effectiveness analysis of antihypertensive therapy: nifedipine SR–candesartan compared with amlodipine–ramipril in hypertensive patients at Ciracas Regional Hospital
Hypertension is one of the main causes of mortality and morbidity in Indonesia and generally occurs asymptomatic and thus frequently referred to as the silent killer. Long-term therapy is essential, as uncontrolled hypertension can worsen the health and economic status of those affected. First-line…
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Journal Article
Development and evaluation of collagen peptides from milkfish (Chanos chanos) scale waste as a potential biopreservative candidate
The escalating health concerns associated with synthetic food preservatives necessitate the exploration of biocompatible, natural alternatives. With mounting toxicological evidence linking these chemical agents to severe metabolic and neurological disorders, the transition toward safe, sustainable…
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Journal Article
Transdermal patch for boil treatment using a combination of ethanol extracts from Hibiscus sabdariffa and Aloe barbadensis
Boils (furuncles) are skin infections brought on by Staphylococcus aureus, characterized by inflamed, pus-filled lumps. Plants like roselle (Hibiscus sabdariffa) and aloe vera (Aloe barbadensis) that have antibacterial and anti-inflammatory properties may be used in treatment. When combined, they…
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Journal Article
Characterization of citric acid-nicotinamide cocrystals prepared by the grinding method for enhanced stability of effervescent products
Effervescent dosage forms contain acidic and basic components that react upon dissolution in water to releasing carbon dioxide (CO₂). In this study, citric acid was selected as the acidic component due to its affordability, high water solubility, and greater acidity than tartaric acid, while sodium…
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Journal Article
Medication adherence and glycemic control outcomes among type 2 diabetes mellitus patients
Type 2 Diabetes Mellitus (T2DM) remains a major public health concern in Indonesia due to its high prevalence and potential to cause various long-term complications when glycemic control is not adequately maintained. Medication adherence and barriers to treatment are important factors that may…
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Journal Article
Inhibitory activity of Carica pubescens leaf extract on cyclooxygenase: anti-inflammatory prospects of natural substances
Inflammation represents a multifaceted biological reaction that plays a significant role in a variety of chronic pathological conditions and the search for natural anti-inflammatory agents remains a significant focus of pharmacological research. The objective of this study was to assess the in…
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Journal Article
The effect of Aerva anata (linn) ethanol extract on implantation sites and endometrial thickness of female mice (Mus musculus)
Aerva lanata (Linn.) contains secondary metabolites with antifertility potential, such as alkaloids, tannins, saponins, steroids, and flavonoids. The increasing need for accessible, cost-effective, and reversible contraceptive options further underscores the importance of investigating plant-based…
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Journal Article
Cost-minimization analysis of nifedipine compared to amlodipine in uncomplicated preeclampsia at secondary referral hospital setting
Nifedipine and amlodipine are both used in clinical practice as antihypertensive options for the management of preeclampsia. Although nifedipine is more commonly recommended, amlodipine is also used in practice, and evidence suggest that both offer comparable outcomes. Existing studies on…
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Journal Article
Metabolite profiling and computational analysis of alkaloids of Carica papaya L. var. California leaves ethanol extract as a drug candidate
Papaya (Carica papaya L.) var. California leaves are widely used as traditional medicine. Several scientific studies have demonstrated that papaya leaves possess biological and pharmacological properties, with potential to be developed into a therapeutic agent. Papaya contains major secondary…
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Journal Article
FTIR spectroscopic and multivariate analysis for sample discrimination and adulteration detection of ulin seed (Eusideroxylon zwageri Teijsm. & Binn.) oil
Ulin seed oil has been empirically used by the people of Kalimantan as a natural hair darkener and hair growth promoter. However, standardized extraction methods and sample characteristics for ulin seed oil (USO) have not yet been clearly established. This study aims to determine the optimal…
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Journal Article
Formulation and in vivo evaluation of fast disintegrating tablets containing avocado seed extract as an antidiabetic agent in male rats
Avocado seeds, often considered agricultural waste, contain bioactive compounds, such as flavonoids and alkaloids, with promising antidiabetic properties. This study aimed to develop fast disintegrating tablet (FDT) formulations utilizing avocado seed extract with varying concentrations of the…
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Journal Article
Reliability and risk classification agreement of digital HYPOGLYRISK: implications for standardized medication safety services
Hypoglycemia caused by medications is still a major safety issue for people with type 2 diabetes who are in an ambulatory therapy. To support pharmacists lead interventions, structured risk stratification is needed. The Medication-Related Hypoglycemia Risk Score Assessment Tool (HYPOGLYRISK) has…
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Journal Article
MTM-based pharmacist–doctor collaboration and outcomes in type 2 diabetes primary care
Medication Therapy Management (MTM) represents a patient-centered pharmaceutical care strategy that necessitates robust interprofessional collaboration, especially between pharmacists and physicians. Within Indonesia's National Health Insurance framework administered by BPJS Kesehatan, healthcare…
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Journal Article
Enhancing internal quality control protocols in clinical chemistry through sigma metrics: A performance evaluation
The establishment of an accurate and dependable quality control (QC) system is essential for clinical laboratories to guarantee the precision of patient test outcomes. This study sought to enhance internal quality control (IQC) protocols for ten clinical chemistry parameters at the Al Ihsan…
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Journal Article
The effect of the ethyl acetate extract of Eleutherine bulbosa on reducing cholesterol in male white rats
Heart disease and stroke are more likely to occur in people with high cholesterol. Hypercholesterolemia is the cause of one-third of ischemic heart disease worldwide. One of the plants cultivated by communities for traditional medicine is Eleutherine bulbosa, which is used to treat cardiovascular…
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Journal Article
Screening of bioactive compounds of sirih leaves (Piper betle L.) as antibiofilm against the glucosyltransferase of Streptococcus mutans enzyme
Dental caries primarily caused by Streptococcus mutans biofilm, and the critical role of the glucosyltransferase (Gtf) enzyme in its pathogenicity necessitates the search for safer natural alternatives to conventional chemical agents like chlorhexidine. The traditional "manginang" practice…
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Journal Article
Modification of black glutinous rice (Oryza Sativa var. glutinosa) starch: effect on pharmaceutical properties
Black glutinous rice is rich in starch, specifically amylopectin by 92-98%, making it a potential pharmaceutical excipient. However, black glutinous rice starch also has disadvantages, such as poor flowability and compressibility, which necessitate modification. This study investigates the impact…
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Journal Article
Formulation and optimization of avocado (Persea americana) seed oil and extract in sunscreen lotion: physicochemical and in vitro photoprotective evaluation
Ultraviolet (UV) radiation exerts detrimental effects on the skin, including erythema, premature aging, enhanced melanogenesis, and an increased risk of skin malignancies; therefore, sunscreen application is essential for effective photoprotection. Avocado seed oil and its extract demonstrate…