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Journal of Advanced Research
Scopus
ISSN 2090-1232 · Elsevier · 2.362 artikel di indeks
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Artikel Jurnal
Boronic acid derivatives inhibit Candida albicans growth by compromising energy metabolism
Introduction: Fungal infections represent a global health concern with significant implications for human well-being. Among them, refractory and sight-threatening fungal keratitis (FK) poses a serious threat to ocular health. This underscores an urgent need for developing novel antifungal agents to…
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Artikel Jurnal
Comprehension of the age-dependent gut and brain interaction of honey bee workers by integration of multi omics approaches
Introduction: In honey bees, division of labour is a key feature, with age-related behavioural transitions being closely associated with molecular changes in the brain, gut, and microbiota. Despite evidence of both microbiome and brain changes in honey bees, most studies focus on either aspect or a…
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Artikel Jurnal
Immunometabolism of macrophages in the bone microenvironment: a new perspective for bone healing therapy
Background: Immunometabolism, the regulation of immune cell function through metabolic pathways, has emerged as a key focus in regenerative medicine. Traditional bone healing therapies primarily target the osteoblast–osteoclast regulatory axis, overlooking the metabolic reprogramming of immune…
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Artikel Jurnal
Integrating molecular generation and fingerprints transferring for single-molecule theranostics targeting endoplasmic reticulum stress
Introduction: Precise diagnosis and treatment of diseases necessitate quantitative visualization and modulation of subcellular structures. The endoplasmic reticulum (ER), as one of the most essential organelles, presents a complex target due to its intricate morphology and diverse cellular roles…
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Artikel Jurnal
NCOA4-Mediated Ferritinophagy Induces Ferroptosis and Enriches Ferritin-Containing EVs via Ferritin Phase Separation to Promote Mechanical Ventilation-Induced Pulmonary Fibrosis
Introduction: Mechanical ventilation (MV) is essential for treating respiratory failure but can paradoxically lead to pulmonary fibrosis. The mechanisms of MV-induced pulmonary fibrosis (MVPF) remain poorly understood. Ferritinophagy, a novel autophagic process, regulates ferroptosis and the…
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Artikel Jurnal
Negative pressure mechanical signal increases the phosphorylation of eNOS Ser1177 by upregulating HSP90 expression to promote wound angiogenesis
Background: Chronic wound pathogenesis involves impaired angiogenesis. While negative pressure wound therapy (NPWT) clinically promotes angiogenesis, its biomechanical mechanisms remain unclear. Methods: A mechanical stretching model simulating NPWT was established in vitro. Multiomics approaches…
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Artikel Jurnal
Research progress on blood therapy for anti-aging
Background: Blood is best known for its critical roles such as oxygen distribution, nutrient transport, hemostasis, and immune surveillance. However, its impact on biological aging remains unknown. Accumulating evidence indicates that interventions targeting the vascular system may decelerate or…
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Artikel Jurnal
Human serum albumin-derived biosensor for visualizing copper(II) and hydrogen sulfide interactions in cancer cells
Introduction: Accurate monitoring of Cu2+ and H2S levels is one of the most reliable methods for diagnosing tumors and assessing treatment efficacy. However, the development of fluorescent probes capable of detecting Cu2+ and H2S in cancer cells against interference from the tumour microenvironment…
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Artikel Jurnal
Harnessing GhGRDP1 natural variation for enhanced cotton seed yield: a rhamnose-dependent strategy in breeding
Introduction: Breeding high-yield crops has long been a fundamental goal in global agriculture, with seeds serving as the essential vehicle to achieve this aim. Therefore, understanding the regulatory mechanisms of seed size is critical for ensuring food security. Objectives: Our study focused on…
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Artikel Jurnal
MeCP2 dysregulation inhibits mitophagy and impairs neural development in cortical organoids
Introduction: Methylated CpG-binding protein 2 (MeCP2) plays a critical role in the normal development and function of the nervous system. Mutations in MeCP2 have been linked to neurodevelopmental disorders, potentially because of mitochondrial dysfunction and impaired mitophagy. However, the…
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Artikel Jurnal
Biological potential and mechanisms of Brain-Expressed X-linked family proteins in cancers: an updated review
Background: Brain-Expressed X-linked (BEX) family proteins is a relative younger protein family in human being, with limited understanding of its pathophysiological functions in health and disease. So far, The human BEX family consists of five members including BEX1-5, which have highly homologous…
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Artikel Jurnal
Efficient derivation of stable sheep embryonic stem cells opens a new avenue for agricultural and biomedical application
Introduction: Embryonic stem cells (ESCs), capable of generating all adult cell types, hold transformative potential for agriculture and biomedicine. However, stable sheep ESCs derivation remains challenging, limiting their application in further research. Objectives: We aimed to establish stable…
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Artikel Jurnal
Gut microbiota-mediated regulation of skeletal development: A review of mechanistic analysis and interventional strategies
Background: The preadolescent period is a rapid and critical stage of skeletal development. Poor skeletal development during this period can exert profound impacts on children’s growth, motor function, psychosocial adaptability, and long-term quality of life. Current interventional strategies for…
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Artikel Jurnal
Astaxanthin biofortification enhances tobacco tolerance to lead stress through boosting antioxidant defense, reducing Pb accumulation, and modulating detoxification pathways
Introduction: Heavy metal pollution including lead (Pb) has become one of the serious global issues threatening food security, human health, and the ecosystem. Exogenous application of astaxanthin (ATX), a potent natural antioxidant, has been shown to enhance plant tolerance to various abiotic…
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Artikel Jurnal
Disruption of PRC1 components RING1A and RING1B promotes angiogenesis via relieving BMP4 repression
Introduction: Angiogenesis is crucial for tissue homeostasis and vascular regeneration following ischemia or injury. Epigenetic regulation has emerged as a key determinant of angiogenic gene expression. The Polycomb repressive complex 1 (PRC1) is a major epigenetic regulator that mediates gene…
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Artikel Jurnal
Hypothalamic BCL6 signaling modulates energy homeostasis and metabolism by inhibiting STAT3 transcription
Introduction: B-cell leukemia/lymphoma 6 (BCL6) has been implicated in regulating energy metabolism in peripheral tissues; however, its role in the hypothalamic regulation of energy homeostasis remains poorly defined. Objectives: This study aimed to investigate the role of hypothalamic BCL6…
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Artikel Jurnal
TRPA1-kinase axis polarization: Nepetalactone drives pest repulsion and predator attraction via divergent PKC/CaMKII signaling
Introduction: Nepetalactone, an iridoid compound derived from Nepeta cataria, is a potent TRPA1 agonist known to repel hematophagous insects. However, its ecological roles and molecular mechanisms within agricultural ecosystems remain largely unexplored. Objectives: This study aimed to investigate…
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