177 results

Severe COVID-19 Unveils Atypical Familial Hemophagocytic Lymphohistiocytosis due to a Novel Homozygous PRF1 Variant

Nasimeh Vatandoost; Mohsen Jari; Mansour Salehi

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

We report a novel homozygous PRF1 variant, PRF1 (NM_001083116.3):c.343G > A (p.Glu115Lys), identified by whole-exome sequencing (WES) in an 11-year-old girl with atypical familial hemophagocytic lymphohistiocytosis (FHL). The variant, inherited from asymptomatic heterozygous parents, was absent or…

Presence of Antinuclear Antibodies in the Cerebrospinal Fluid and in the Serum in a Patient With Sjögren’s Syndrome and Systemic Lupus: A Case Report

Cherqaoui Ayman; Taif Hiba; Laraki Kenza et al.

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

Systemic lupus erythematosus (SLE) may overlap with Sjögren’s syndrome (SS), leading to complex systemic involvement, including neurological and pulmonary manifestations. We report a 60-year-old woman with a 10-year history of SLE–SS overlap presenting with headaches and bilateral visual…

Wheat-Dependent Exercise-Induced Anaphylaxis Mimicking Acute Asthma in an Adolescent: A Case Report

Xia Zhao; HongBin Song; Hui Li et al.

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

Severe Polymicrobial Pneumonia With Septicemia After Interruption of Immunoglobulin Replacement in X-Linked Agammaglobulinemia: A Case Report

Hau Dinh Tran; Quang Hung Vo; Nghia Phu Nguyen

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

Acute Motor Axonal Neuropathy Coexisting With Ankylosing Spondylitis: A Case-Based Review

Yiğit Can Güldiken; Batool Achmar; Sema Kaymaz Tahra

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

Guillain-Barré syndrome (GBS) is a rare autoimmune disorder characterized by peripheral nerve involvement. Among the many kinds of GBS, acute motor axonal neuropathy (AMAN) syndrome has been shown to have distinct clinical characteristics and consequences. Meanwhile, ankylosing spondylitis (AS) is…

A Novel Variant of CORO1A Gene Contributing to the Development of Primary Immunodeficiency in Children

Alanoud Aljohani; Yazeed Alayed; Bashayer Alrasheed et al.

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

Dragon Fruit Allergy With Cross-Reactivity to Salsola kali and Peach

Lucía Ferrer Clavería; Verónica Perciun; María Teresa Sobrevía Elfau et al.

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

Dragon fruit, also known as pitahaya, has become increasingly popular in Europe and the United States owing to its nutritional value and potential health-promoting properties. This study describes a patient with anaphylaxis after the ingestion of dragon fruit. We present the case of a patient who…

The Patient With Multiple Alloantibodies: A Systematic Strategy for Antibody Identification and Transfusion Management

Ahmed Alharbi; Haya Wasel; Eman Almutairi et al.

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

Serine/Threonine Kinase 4 Deficiency Caused by a Potential Novel c.248del, p.Pro83Leufs∗3 Mutation: A Case Report

Hamidreza Ashayeri; Shabnam Eskandarzadeh; Samin Alavi et al.

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

Anaphylactic Induction of Lupus Nephritis and Posterior Reversible Encephalopathy Syndrome Following Administration of Depo-Provera

Adaora Ezeani; Sarah Staskiewicz

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease in which environmental and medication-related exposures may precipitate disease onset or flares in susceptible individuals, which can result in lupus nephritis (LN) and, in rare cases, posterior reversible encephalopathy…

Rescue of Eosinophilic Cardiac Tamponade by Anakinra in a Pregnant Woman With Familial Mediterranean Fever

Maxime Quaggetto; Matthieu Groh; Lea Savey et al.

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

Familial Mediterranean fever (FMF) is an interleukin-1 (IL-1)-driven autoinflammatory disease in which pericarditis, occasionally complicated by cardiac tamponade, is a recognized manifestation, whereas hypereosinophilia is not. We report a woman in her thirties with FMF (homozygous MEFV M694V…

A Novel MYO5A Mutation (c.3508C>T) in a 27-Month-Old Girl With Hypotonia and Developmental Delay: Expanding the Phenotypic Spectrum of Griscelli Syndrome Type 1

Davoud AmirKashani; Soudabeh Hosseini; Marziyeh Mojbafan et al.

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

Diagnosing Hyper IgE Syndrome in a Resource-Limited Setting: A Case Report Highlighting the Utility of Clinical Scoring and Multidisciplinary Management

Roshna Devi; Huda Raja; Prithvi Raj et al.

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

Supplemental Bee Pollen Ingestion With Resultant Anaphylaxis and Allergic Asthma: Case Report

Erin Eickholt; Victoria Norelli; Kathleen Martin et al.

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

Bee pollen has become an increasingly popular dietary supplement due to potential therapeutic effects. However, ingestion has been shown to trigger allergic responses as severe as anaphylaxis. This case highlights allergic asthma development in a 26-year-old female patient with subsequent…

BCG-Related Immune Reconstitution Inflammatory Syndrome and Delayed Donor Chimerism After Allogeneic HSCT in T−B−NK+ SCID: A Successful Report of Steroid-Sparing Management

Seyed Reza Abdipour Mehrian; Sarah Ravankhah; Kiarash Kavari et al.

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

Not All That Itches Is DRESS: A Case Report of Lichenified Dermatosis and Hypereosinophilia Associated With Tocilizumab

Mani Maheshwari; Brian Swick; Benjamin Davis et al.

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

Drug-induced hypereosinophilic syndromes (HESs) have been associated with a variety of medications, including biologic agents. We present a case of an 85-year-old female with a history of giant cell arteritis (GCA) complicated by ascending aortic aneurysm and aortitis, who developed marked…

Granulomatosis With Polyangiitis Presenting as Pulmonary Nodules: A Case Study and Literature Review

Yanghang Chen; Haihong Zheng; Liuyang Gong

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

This article presents a case of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)–positive granulomatosis with polyangiitis (GPA) presenting initially as chronic cough. Pulmonary shadows persisted and progressed despite antibiotic therapy. The diagnosis was confirmed by lung biopsy…

Homozygous C1qA Deficiency Presenting as Early-Onset Systemic Lupus Erythematosus: A Case Report With a Literature Review

Hadi Mottaghipisheh; Andisheh Mosaffa Jahromi; Fatemeh Mirzaei et al.

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

False Elevation of Parathyroid Hormone in a Patient With Lung Metastasis of Rectal Cancer After Immunotherapy: A Case Report and Literature Review

Chang-Sheng Xia; Lingli Zhou; Chendi Jing et al.

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

Early Severe Pseudomonas Infections Revealing MyD88 Deficiency in Two Siblings: A Case Report

Louise Belenger; Laure Kornreich; Céline Mignon et al.

Case Reports in Immunology, Vol. 2026 · 2026 · English · DOAJ Scopus

MyD88 deficiency is an innate immune deficiency that confers susceptibility to bacterial infections, particularly S. pneumoniae, S. aureus, and P. aeruginosa. This autosomal recessive deficiency was first described in 2008 by Van Bernuth et al. Most infections occur before the age of two and can be…