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Endocrinology and Metabolism
Scopus
ISSN 2093-596X · Korean Endocrine Society · 1.221 artikel di indeks
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Artikel Jurnal Teks lengkap
From Anabolic to Reponic: Reclassifying Insulin’s Primary Metabolic Role
The classification of insulin as primarily an anabolic hormone is inconsistent with its metabolic signature of energy storage. This categorization, shared with anabolic hormones such as testosterone, obscures insulin’s role in the pathophysiology of metabolic disease. We propose a more precise…
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Sarcopenia and Muscle Aging: Updated Insights into Molecular Mechanisms and Translational Therapeutics
Sarcopenia is a progressive, age-related condition characterized by the loss of skeletal muscle mass, strength, and function, which increases the risk of falls, frailty, and loss of independence. Despite growing recognition and its incorporation into geriatric assessments, there is still no…
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Consensus on the Diagnosis of Cushing’s Disease: A Collaborative Statement from the Korean Endocrine Society and Japan Endocrine Society
Cushing’s disease (CD) is a rare but serious endocrine disorder caused by excessive cortisol secretion due to adrenocorticotropic hormone–secreting pituitary tumors. Despite recent developments in diagnostic criteria and treatment options, CD remains associated with substantial comorbidities and…
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Effects of Progranulin Deficiency on Inflammation and Fibrosis in the Kidneys and Liver of Diabetic Mice Fed a High-Fat Diet
Background Progranulin (PGRN) is an important regulator of inflammation, insulin resistance, and autophagy. However, the effects of PGRN deficiency on these processes in the kidneys and liver in diabetes remain unclear. In addition, the differential effects of PGRN deficiency and sodium-glucose…
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A Comparative Evaluation of Three Time-to-Event Models Predicting 5-Year Osteoporosis Risk in Thyroid Cancer Survivors: A Nationwide Cohort Study
Background Osteoporosis is a common complication among thyroid cancer survivors; however, predictive tools for this condition remain inadequate. This study aimed to develop time-to-event prediction models for assessing osteoporosis risk in thyroid cancer patients. Methods Using the Korean National…
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Postpartum Glucose Intolerance in Women with a History of Gestational Diabetes Mellitus: An In-Depth Review
Gestational diabetes mellitus (GDM) is increasing in prevalence worldwide, and postpartum glucose intolerance represents one of the major complications after delivery in women with GDM. A wide range of risk factors for postpartum glucose intolerance have been identified, including ethnicity…
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Nationwide Big Data Studies of Endocrine Diseases Using the Korean National Health Information Database: Research Trends and Standardization of Operational Definitions
The Korean National Health Information Database (NHID) is a large-scale dataset created through linkage of National Health Insurance claims with nationwide health screening records. Because it is released in a cohort-based format, the NHID enables longitudinal follow-up and allows investigation of…
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Reduced Sphingosine-1-Phosphate Levels Exacerbate Type 2 Diabetes Mellitus and Associated Complications in a High-Fat Diet Mouse Model
Background Type 2 diabetes mellitus (T2DM) is increasingly prevalent and frequently associated with obesity, insulin resistance, nonalcoholic fatty liver disease, and chronic kidney disease. Emerging evidence suggests sphingosine-1-phosphate (S1P), a bioactive sphingolipid, plays a significant role…
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Current Knowledge on Atypical Parathyroid Tumors and Emerging Strategies for Risk Stratification
Atypical parathyroid tumors (APTs) are an uncommon subset of parathyroid neoplasms that carry substantial clinical relevance because of their histological and clinical resemblance to parathyroid cancer. Despite this importance, the diagnosis of APTs remains persistently challenging, even for…
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Impact of Carbohydrate Intake Fluctuations on Glucose Profiles: Insights from Continuous Glucose Monitoring-Based Patient Clustering
Background Continuous glucose monitoring (CGM) is widely applied in daily glucose management. However, its potential to categorize individuals based on glucose profiles is not fully established. This study employed CGM-based patient clustering and examined nutritional factors influencing glucose…
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New Sparks and Spots: Molecular Imaging with Positron Emission Tomography Will Change Management of Cushing’s Disease
Cushing’s disease is caused by corticotroph tumors of the pituitary gland, resulting in adrenocorticotropic hormone hypersecretion and cortisol excess. The majority of the tumors are microadenomas. Magnetic resonance imaging (MRI) imaging is able to detect up to 70% of the corticotroph tumors. In…
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Distinct Pituitary-Adrenal Responses to Hypoglycemia in Type 1 and Type 2 Diabetes
Background Hypoglycemia remains a major barrier to optimal glycemic control in diabetes. Counter-regulatory hormonal responses, particularly those involving the pituitary and adrenal systems, play a central role in mitigating hypoglycemia, yet differences between diabetes subtypes are not well…
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Growth Hormone, Not Simply Just a Hormone for Growth
Since its discovery almost 100 years ago, growth hormone (GH) has been extensively studied to elucidate its structural characteristics, receptor interactions and its physiologic and non-physiologic effects. These actions include but are not limited to its effects on somatic growth, substrate…
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LGALS3BP Induces Insulin Resistance via TLR2-IKKα/β Pathway-Mediated IRS1 Serine Phosphorylation
Background Insulin resistance (IR) disrupts hepatic glucose and lipid metabolism, contributing to metabolic dysfunction-associated steatotic liver disease (MASLD) and progression to severe liver complications. Galectin-3-binding protein (LGALS3BP) is a secreted glycoprotein implicated in…
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Nationwide Survey of Korean Endocrinologists on Barriers to Implementing Smart Healthcare Technologies
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Association of Abdominal Myosteatosis and Visceral Fat Obesity with Arterial Stiffness
Background Arterial stiffness with aging predicts cardiovascular diseases (CVDs) and target organ damage. While sarcopenia has been linked to arterial stiffness, the association of myosteatosis and visceral adiposity with arterial stiffness remains underexplored. As age-related fat redistribution…
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Hypercortisolism in Type 2 Diabetes with Treatment-Resistant Hyperglycemia: A Treatable Metabolic Phenotype?
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Decline in Years of Life Lost Due to Diabetes in Korea, 2008–2019: A Cause-Specific Decomposition Analysis
Background This study aimed to evaluate trends in years of life lost (YLL) attributable to diabetes and to identify cause-specific contributors to these changes in Korea. Methods We analyzed data from the Korean National Health Insurance Service-National Sample Cohort between 2008 and 2019…
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Artikel Jurnal Teks lengkap
Hypothalamus–Peripheral Organ Crosstalk in Energy Metabolism: A Bidirectional Regulatory Network
Systemic energy balance depends on the hypothalamus, a central brain hub composed of specialized nuclei that detect circulating hormones, nutrients, and metabolites and coordinate endocrine and autonomic responses. Although the arcuate nucleus (ARC), ventromedial hypothalamus (VMH), and…
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