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Journal of Pharmaceutical Analysis
Scopus
ISSN 2095-1779 · Elsevier · 1.463 artikel di indeks
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Artikel Jurnal
Advancements in pharmaceutical research on traditional Chinese medicine-metal complexes
Traditional Chinese medicine (TCM) has gained significant recognition as an adjuvant treatment modality for cancer, infections, and inflammatory diseases, owing to its outstanding antitumor, antimicrobial, and anti-inflammatory properties. With the advancement of TCM-based coordination chemistry…
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Artikel Jurnal
Carbon dots derived from natural medicines: Therapeutic advances and challenges
Carbon dots (CDs) are a novel nanomaterial exhibiting exceptional biocompatibility, tunable fluorescence, and versatile functionality, making them a promising candidate in biomedicine. Natural medicines, including plants, animals, minerals, and their extracts, represent ideal precursors for CD…
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Artikel Jurnal
Large-scale evaluation of HIV-1 DNA drug resistance testing as a robust tool for clinical decision-making: A nationwide study in China
Human immunodeficiency virus type 1 (HIV-1) drug resistance remains a major challenge in HIV/AIDS management, particularly in individuals with low-level viremia (LLV) where RNA-based drug resistance testing (DRT) often fails. Although HIV-1 DNA DRT represents a promising alternative, its clinical…
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ERBB2 mutations promote recurrence and metastasis in non-muscle-invasive bladder cancer via HIF-1 phosphorylation: Insights from whole exome sequencing
This study investigates the role of ERBB2 mutations in promoting recurrence and metastasis of non-muscle-invasive bladder cancer (NMIBC). Analysis of whole exome sequencing (WES) data from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) databases revealed a…
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Artikel Jurnal
Beyond conventional therapies: Gut microbiota modulation and macromolecular drugs in the battle against cardiometabolic diseases
Cardiometabolic diseases (CMDs) represent an ongoing major global health challenge, driven by complex interactions among genetic, environmental, microbiome-related, and other factors. While small-molecule drugs and lifestyle interventions can provide clinical benefits, they are possible to be…
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A comprehensive review on herbal approaches for treatment of urinary tract infections: Scope and challenges
Urinary tract infections (UTIs) have become a major health concern globally, necessitating effective treatments for mitigating discomfort and avert complications. The uropathogens commonly associated with UTIs in humans such as Bacillus species, Staphylococcus aureus (S. aureus), Pseudomonas…
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Artikel Jurnal
Integrating high-resolution bioassay profiling with affinity-based ligand fishing for unveiling galloylated derivatives as novel catechol-O-methyltransferase inhibitors in Paeonia lactiflora Pall.
Catechol-O-methyltransferase (COMT) inhibition is a critical therapeutic strategy for Parkinson's disease (PD), yet clinical inhibitors face limitations in bioavailability and hepatotoxicity, driving demand for novel natural scaffolds. In this study, we developed an integrated analytical platform…
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FPS_P/N: A two-dimensional mass spectrometry utilization program with precursor ion determination for accurately distinguishing anthocyanin from other flavonoids
Anthocyanins, a unique class of flavonoids with flavylium skeletons, are valued for antioxidant properties. However, distinguishing anthocyanins from co-existing flavonoids using conventional automated tandem mass spectrometry (MS) analysis methods remains challenging. This difficulty arises from…
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Tumor-associated macrophages in hepatocellular carcinoma: Cellular plasticity and therapy resistance in crosstalk
Hepatocellular carcinoma (HCC) is the predominant type of liver cancer. There are different risk factors for HCC including viral infection, liver fibrosis, non-alcoholic fatty liver disease, environmental factors and genomic alterations. The tumor microenvironment (TME) has been proposed as a…
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Artikel Jurnal
Targeted nano-drug delivery systems for tumor immunotherapy
While being a safe and effective precision therapy strategy, tumor immunotherapy still fails in many patients due to the immunosuppressive tumor microenvironment. Emerging evidence has indicated that the targeted nano-drug delivery systems can accurately deliver therapeutic agents to potentiate the…
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Synergistic antibacterial and anti-inflammatory potentials of dual-loaded self-healing hydrogel for methicillin-resistant Staphylococcus aureus-infected wound healing
The emergence of drug-resistant bacterial infection and persistent biofilm colonization pose a rigorous challenge to effective wound healing and regeneration, necessitating the innovative therapeutic strategies to combat these pressing clinical crises. Herein, nortriptyline, a novel United States…
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Artikel Jurnal
Pharmacological mechanisms of natural products with antidepressant effects: A focus on the programmed cell death regulation
Depression is a prevalent mental disorder characterized by persistent disinterest and a depressed mood, with severe cases potentially leading to suicide. In recent years, the incidence of depression has steadily increased, making it the second-largest global health burden. The pathogenesis of…
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Artikel Jurnal
Targeting SH3GL1 for prognosis and immune response in breast cancer
The cuproptosis-related gene (CRG) SH3GL1 is identified as a pivotal regulator in breast cancer (BRCA) progression and immune regulation in this study. Through gene expression profiling and meta-analysis of public datasets, SH3GL1 was found to be overexpressed in BRCA tumor tissues and correlated…
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Artikel Jurnal
Ferroptosis and retinal ganglion cell death in glaucoma: Mechanisms and therapeutic approaches
Glaucoma represents a predominant worldwide etiology of permanent vision impairment; it is clinically manifested through progressive neuronal atrophy in retinal ganglion cells (RGCs) and is accompanied by axonal degeneration in the optic pathway. Given the limited efficacy of conventional…
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