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Reproductive and Developmental Medicine
Scopus
ISSN 2096-2924 · Wolters Kluwer Health/LWW · 200 artikel di indeks
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Artikel Jurnal
Mechanism of the Salvia miltiorrhiza–Codonopsis pilosula drug pair in the treatment of premature ovarian failure based on network pharmacology-molecular docking
Abstract. Objective:. Premature ovarian failure (POF) is a disease characterized by irregular menstruation and results in infertility which markedly affects the reproductive health of women. The Salvia miltiorrhiza–Codonopsis pilosula drug pair is effective at treating POF; however, knowledge of…
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Artikel Jurnal
Medium-chain acyl-CoA dehydrogenase deficiency: prevalence of ACADM pathogenic variants c.985A>G and c.199T>C in a healthy population in Rio Grande do Sul, Brazil
Abstract. Objectives:. To investigate the prevalence of ACADM pathogenic variants, c.985A>G and c.199T>C, for medium chain acyl CoA dehydrogenase deficiency (MCADD) in a healthy population in the southern region of Brazil. Methods:. This was an observational cross-sectional study with a convenience…
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Artikel Jurnal
Mechanical stress-induced Hippo signaling in respect to primordial follicle development and polycystic ovary syndrome pathogenesis
Abstract. Polycystic ovary syndrome (PCOS) is a heterogeneous reproductive disease that can cause infertility. The Hippo signaling pathway, a network highly conserved throughout evolution, maintains the balance between follicle proliferation and dormancy. Dynamic changes in primordial follicles…
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Artikel Jurnal
Effect of vitrification on clinical outcomes of cleavage-stage embryos with poor quality in human embryo cryopreservation
Abstract. Objective:. To evaluate the effect of morphologic factors on survival rate (SR), pregnancy rate (PR), and implantation rate (IR) of human embryo vitrification following frozen embryo transfer (FET) on day 3 post-ovulation. Methods:. Women undergoing FET (n = 921) with embryos…
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Artikel Jurnal
Source of human oocytes for infertility treatment and fertility preservation
Abstract. The source of human oocytes is directly associated with the success of infertility treatment and fertility preservation. The number of oocytes obtained is possibly correlated with the success rate in terms of live birth rates. However, oocyte quality must be refined such that the number…
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Artikel Jurnal
How fertility preservation guidelines have progressed worldwide: Potential implications and inspiration
Abstract. To summarize fertility preservation (FP) guidelines and consensus provided by medical facilities worldwide. Five reference databases (PubMed/Embase, China BioMedical Literature Database, ClinicalKey, Wanfang Data, and China Knowledge Resource Integrated) and 7 guideline databases…
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Artikel Jurnal
Character of cell-free genomic DNA in embryo culture medium and the prospect of its clinical application in preimplantation genetic testing
Abstract. There is increasing evidence that cell-free DNA (cfDNA) in spent culture media (SCM) can be amplified for genetic testing. Therefore, this paper reviews the characteristics of cfDNA, including its fragment size, amount, origin, as well as some factors affecting the success rate of its…
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Artikel Jurnal
Offspring from oocytes grown in frozen–thawed ovarian tissues transplanted to male and female bodies
Abstract. Objective:. There are few reports of live births from heterotopic transplantation of frozen-thawed ovarian tissue. The purpose of this study is to assess the follicular development in the frozen-thawed ovarian tissues following heterotopic transplantation in both female and male bodies…
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Artikel Jurnal
Gastroschisis at the León University Hospital, Nicaragua
Abstract. Objective:. The prevalence of midline birth defects, such as gastroschisis, has increased worldwide, over the last few decades. This study aims to explore the prevalence, maternal epidemiological characteristics, and natural history of neonates affected by gastroschisis at the University…
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Artikel Jurnal
Non-invasive chromosome screening for embryo preimplantation using cell-free DNA
Abstract. Preimplantation genetic testing (PGT) is a widely adopted screening method that can be performed to identify and select embryos with normal ploidy; however, PGT relies on embryo biopsy, that is, polar body, embryo cells, or trophectoderm biopsy, to obtain embryonic DNA, increase its…
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Artikel Jurnal
Chinese expert consensus on clinical practice of female fertility preservation
Abstract. Many female fertility preservation-related technologies have recently been developed in response to increasing demand for such treatments. To establish standard practices of female fertility preservation in China, the Chinese Maternal and Child Health Association Affiliated Fertility…
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Artikel Jurnal
Role of fatty acids and calcium in male reproduction
Abstract. Both fatty acids (FAs) and calcium ions play important roles in contraceptive cycles via several systems. Polyunsaturated FAs (PUFAs) act as precursors for prostaglandin production and can alter the expression of numerous crucial catalysts that are involved in prostaglandin and steroid…
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Artikel Jurnal
Microcephaly prevalence after the 2015 to 2016 Zika outbreak in Tangará da Serra, Brazil: a population-based study
Abstract. Objective:. Prenatal infection with the Zika virus (ZIKV) can lead to congenital Zika syndrome (CZS), characterized by microcephaly and brain injury. However, there are questions regarding the prevalence of microcephaly/CZS after the ZIKV outbreak in defined geographic areas. This study…
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Artikel Jurnal
Cilia and their role in neural tube development and defects
Abstract. Cilia are microtubule-based filamentous organelles that play a vital role in embryogenesis. Multiple signal transduction pathways are orchestrated by cilia, such as Hedgehog and planar cell polarity signals. Various studies, spanning over last 2 decades, have emphasized the role of…
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Artikel Jurnal
Liquiritin ameliorates metabolic and endocrine alterations in a mouse model of polycystic ovary syndrome
Abstract. Objective:. Altered bile acid transformation induces low-grade chronic inflammation and may play an important role in the pathophysiology of polycystic ovary syndrome (PCOS). Liquiritincan regulate bile acid metabolism and anti-inflammatory properties; however, limited information is…
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Artikel Jurnal
Transcription factors dysregulated in three complex birth defects datasets
Abstract. Objective:. To investigate the roles of transcription factors (TFs) in the etiology of complex human birth defects, including neural tube defects (NTDs), congenital heart diseases (CHDs), and hypospadias. Methods:. We examined the overlap of genetically associated genes among NTDs, CHDs…
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Artikel Jurnal
Molecular mechanisms underlying cell-fate specification and cellular diversity of the trophoblast lineage during placental morphogenesis in mice
Placental morphogenesis is a highly dynamic process involving mutual recognition and interlacing between the trophoblast–uterus and ultimately the initiation of the maternal–fetal circulatory system. During placental morphogenesis in mice, the trophoblast lineage, which integrates maternal and…