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精准医学杂志
ISSN 2096-529X · Editorial Office of Journal of Precision Medicine · 444 artikel di indeks
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Artikel Jurnal Teks lengkap
Efficacy and safety of tirofiban in treatment of acute progressive cerebral infarction
Objective To investigate the efficacy and safety of tirofiban in the treatment of acute progressive cerebral infarction (APCI). Methods A total of 88 patients with APCI were enrolled as subjects, and they were divided into treatment group and control group using a random number table, with 44…
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Construction of an interpretable machine learning model based on Delta radiomic features of intratumoral and peritumoral regions on multi-parametric MRI for predicting the efficacy of neoadjuvant therapy for breast cancer
Objective To construct an interpretable machine learning model based on Delta radiomic features of intratumoral and peritumoral regions on multi-parametric MRI, and to evaluate its performance in predicting pathological complete response (pCR) after neoadjuvant therapy (NAT) in patients with breast…
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Effect of neural precursor cell-expressed, developmentally down-regulated 9 on the invasion and migration of colorectal cancer cells and its mechanism
Objective To investigate the role and molecular mechanism of neural precursor cell expressed, developmentally down-regulated 9 (NEDD9) in the invasion and migration of colorectal cancer (CRC) cells. Methods Human CRC HCT116 cells were divided into the following groups: HCT116 group (conventional…
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Effect of celastrol on the repair of sciatic nerve injury in rats and its mechanism of action
Objective To investigate the effect of celastrol on the repair of sciatic nerve injury in rats and its mechanism of action. Methods Six-week-old male Sprague-Dawley (SD) rats were divided into groups A-C and groups A1-C1. Groups A and A1 were sham-operation groups; the rats in groups B and B1 were…
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Effect of scaffold protein DLGAP1 on the malignant phenotype of breast cancer cells and the underlying mechanism
Objective To investigate the effect of scaffold protein DLGAP1 expression on the malignant phenotype of breast cancer cells and the underlying mechanism. Methods MDA-MB-231-mCherry (hereinafter referred to as 231) cells, a human triple-negative breast cancer cell line, were divided into the…
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Value of three-dimensional speckle-tracking imaging in assessing right ventricular systolic function in patients with complete left bundle branch block and different left ventricular ejection fractions
Objective To assess right ventricular systolic function in patients with complete left bundle branch block (CLBBB) and different levels of left ventricular ejection fraction (LVEF) using three-dimensional speckle-tracking imaging (3D-STI). Methods A total of 52 patients who were diagnosed with…
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Regulatory effect of DNA methyltransferase 1 and DNA methyltransferase 3A on autophagy of human gastric cancer cells
Objective To investigate the regulatory effect of DNA methyltransferase 1 (DNMT1) and DNA methyltransferase 3A (DNMT3A) on autophagy of gastric cancer cells. Methods Western blot was used to measure the protein expression levels of DNMT1, DNMT3A, and DNA methyltransferase 3B (DNMT3B) in human…
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Effect of dihydroartemisinin on the adhesion, migration, invasion, and epithelial-mesenchymal transition of human hepatocellular carcinoma cells and its mechanism
Objective To investigate the effect of dihydroartemisinin on the adhesion, migration, invasion, and epithe-lial-mesenchymal transition (EMT) of human hepatocellular carcinoma HCCLM3 cells and to elucidate its mechanism. Methods Human hepatocellular carcinoma HCCLM3 cells were divided into groups…
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Efficacy and safety of adalimumab in treatment of children with different subtypes of non-systemic juvenile idiopathic arthritis
Objective To investigate the efficacy and safety of adalimumab in the treatment of children with different subtypes of non-systemic juvenile idiopathic arthritis (JIA). Methods A retrospective analysis was performed for the clinical data of 82 children with non-systemic JIA who were diagnosed and…
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Analysis of clinical characteristics of patients with external auditory canal and temporal bone hemangiomas
Objective To analyze the clinical characteristics of external auditory canal and temporal bone hemangiomas, and to improve the diagnosis and treatment of these conditions. Methods A retrospective analysis was conducted on the clinical data of six patients with external auditory canal hemangiomas…
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Effect of nuclear casein and cyclin-dependent kinase substrate 1 gene on the proliferation of breast cancer cells and its association with different molecular subtypes of breast cancer
Objective To investigate the effect of nuclear casein and cyclin-dependent kinase substrate 1 (NUCKS1) gene on the proliferation of breast cancer cells and its association with different molecular subtypes of breast cancer. Methods TCGA and GTEx Databases were used to analyze the expression of…
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Efficacy of ARID1A mutation in predicting immunotherapy response in gastric adenocarcinoma and establishment of a predictive model
Objective To investigate the value of ARID1A mutation in tumor tissue in predicting immunotherapy response in gastric adenocarcinoma, and to establish a clinical predictive model. Methods A total of 777 patients with gastric adenocarcinoma from the cBioPortal for Cancer Genomics Database were…
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Risk factors for gastrointestinal bleeding in patients with chronic kidney disease
Objective To investigate the risk factors for gastrointestinal bleeding (GIB) in patients with chronic kidney disease (CKD). Methods A total of 335 CKD patients who were admitted to The Affiliated Hospital of Qingdao University from April 2023 to October 2025 were enrolled, and according to the…
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Research advances in the mechanism of the relationship between epilepsy and sleep disorders
Sleep disorders may induce or exacerbate epilepsy, and seizures may interfere with the status of sleep. There are complex mechanisms for the comorbidity between sleep disorders (such as insomnia, obstructive sleep apnea, narcolepsy, and restless legs syndrome) and epilepsy; narcolepsy and epilepsy…
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A rare case of cardio-facio-cutaneous syndrome: A case report and literature review
Objective To investigate the clinical phenotype and genetic characteristics of a child with cardio-facio-cuta-neous syndrome (CFCS), and to evaluate the efficacy and safety of growth hormone therapy through a literature review. Methods Clinical data were collected from a child with CFCS and poor…
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Effect of aquaporin 5 on ferroptosis in lens epithelial cells and its mechanism
Objective To investigate the effect and mechanism of aquaporin 5 (AQP5) on ferroptosis in lens epithelial cells (LECs). Methods Immortalized human LECs (SRA01/04 cells) were divided into empty lentiviral vector control group (group A), stable AQP5 knockdown group (group B), and stable AQP5…
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Construction and validation of a predictive model for the prognosis of hepatocellular carcinoma based on immunogenic cell death-related genes
Objective To construct a predictive model for the prognosis of patients with hepatocellular carcinoma (HCC) based on immunogenic cell death (ICD)-related genes, and to assess its clinical translational value. Methods A total of 365 HCC patients were selected from the Liver Hepatocellular Carcinoma…
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Advances in pharmacotherapy for secondary hyperparathyroidism in chronic kidney disease
Secondary hyperparathyroidism (SHPT) is a common complication in patients with chronic kidney disease (CKD), which can occur at any stage of CKD, with an incidence rate of as high as 40%-80% in patients undergoing maintenance hemodialysis. Pharmacotherapies for SHPT in clinical practice mainly…
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Value of terahertz three-dimensional tomography in differentiating tumor tissue from normal tissue in a nude mouse model of lung adenocarcinoma
Objective To investigate the value of terahertz three-dimensional (3D) tomography in differentiating central tumor tissue from adjacent normal tissue in a nude mouse model of lung adenocarcinoma. Methods A nude mouse model of subcutaneous lung adenocarcinoma was successfully established, and then…
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Inhibitory effect of cadonilimab on hepatocellular carcinoma cells and its mechanism
Objective To investigate the inhibitory effect of cadonilimab (anti-PD-1/CTLA-4) on hepatocellular carcinoma cells and its mechanism. Methods CCK-8 assay was used to assess the effect of different concentrations of cadonilimab (0, 0.3, 3, 30, 300, 3 000 nmol/L) on the viability of human…