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Medeniyet Medical Journal
Scopus
ISSN 2149-2042 · Istanbul Medeniyet University · 241 artikel di indeks
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Artikel Jurnal
Cardiomegaly of Unknown Origin: Why Morphology Still Matters in the Genetic Era - A Case of Cardiac Fabry Disease
We report a 72-year-old man with long-standing hypertension, type 2 diabetes, and ischemic heart disease, in whom autopsy, following a fatal acute coronary syndrome, revealed marked cardiomegaly (heart weight, 911 g) and concentric myocardial hypertrophy (left ventricular wall thickness up to 2.4…
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Artikel Jurnal
Bowel Management Protocols in Pediatric Chronic Constipation and Complex Colorectal Dysfunction: A Systematic Review of Sennoside Dosing, Evacuation Strategies, and Radiologic Monitoring
To synthesize evidence on pediatric bowel rehabilitation protocols for chronic constipation and complex colorectal dysfunction, with emphasis on sennoside dosing, disimpaction, mechanical evacuation, radiologic monitoring, outcomes, and adverse events, we conducted a systematic review following…
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Artikel Jurnal
Vestibular Migraine: A Systematic Literature Search and Narrative Review of Diagnostic Criteria, Pathophysiology, Differential Diagnosis, and Treatment Approaches
This review aimed to summarize current evidence on the diagnostic criteria, pathophysiological mechanisms, differential diagnosis, and treatment approaches of vestibular migraine. A systematic literature search was conducted in PubMed/MEDLINE, Web of Science, and the Cochrane Library for studies…
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Artikel Jurnal
A Critical Synthesis of Machine Learning in Autism Spectrum Disorder Genomic Research: From Transcriptomics to Microbiome
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by persistent impairments in social communication, restricted interests, and repetitive behaviors. This narrative review synthesizes advances in machine learning applications to ASD genomic research through May…
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Artikel Jurnal
Evaluation of Early Diagnostic Methods for Subclinical Cardiovascular Changes in Childhood Obesity
Childhood obesity is associated with early cardiometabolic abnormalities and subclinical vascular and cardiac changes. This narrative review summarizes the mechanisms underlying these changes and evaluates non-invasive methods used for early detection. PubMed/MEDLINE and Scopus were searched for…
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Artikel Jurnal
Oleuropein Reduces Secondary Injury Pathways After Experimental Spinal Cord Injury Via HMGB1-Associated Signaling
Objective: Spinal cord injury (SCI) can cause profound disability and substantial morbidity and mortality. Oleuropein (OLE) is a phenolic compound with anti-inflammatory and antioxidant effects. High mobility group box 1 (HMGB1), released extracellularly after tissue injury, can amplify…
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Artikel Jurnal
Differentiating Pure and Mixed Mucinous Breast Carcinoma Using Multimodality Imaging: A Retrospective Single-Center Study
Objective: This study aimed to evaluate the efficacy of mammography, ultrasound, and magnetic resonance imaging (MRI) features in differentiating pure from mixed mucinous breast carcinoma and in identifying imaging characteristics specific to each subtype. Methods: This retrospective single-center…
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Artikel Jurnal
Neutrophil-to-HDL-C Ratio and Anatomically Significant Multivessel Disease Across Acute Coronary Syndrome Phenotypes
Objective: The neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) is an emerging inflammatory-lipid biomarker. Whether NHR is associated with anatomically significant multivessel disease (MVD) across different acute coronary syndrome (ACS) phenotypes remains unclear. Methods: We…
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Methodological Reporting Quality of Artificial Intelligence-Based Orthopedic Studies: A Literature Analysis
Objective: We set out to examine how completely artificial intelligence (AI)-based orthopedic studies report their methods. Methods: A PubMed search covering 2023-2025 was run with a predefined strategy. Screening of titles, abstracts and full texts left 280 eligible papers, and 200 of these were…
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Artikel Jurnal
Impact of Septoplasty on Cognitive Function
Objective: This study explored the impact of septoplasty on cognitive functions, including selective attention, information processing speed, and response inhibition and investigated the factors associated with these effects. Methods: A total of 73 patients who underwent septoplasty for septal…
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Artikel Jurnal
In Vitro Antifungal Activity of Commonly Used Antiseptics and Disinfectants Against Candida auris Isolates
Objective: Candida auris (C. auris) has emerged as a multidrug-resistant nosocomial pathogen associated with outbreaks in healthcare settings and high mortality rates. Its ability to persist in the hospital environment highlights the importance of effective disinfection strategies. This study aimed…
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Artikel Jurnal
Caspase-8 Polymorphism and Colorectal Cancer Risk: A Meta-Analysis of 35,854 Subjects
Objective: Caspase-8 (CASP8) is essential for apoptotic clearance of transformed cells and is encoded by the CASP8 gene. The CASP8 -652 6N del polymorphism (rs3834129) has been studied in relation to colorectal cancer (CRC) risk with conflicting outcomes. This meta-analysis aims to provide a…
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Artikel Jurnal
Predictive Value of the Intermountain Mortality Risk Score for Saphenous Vein Graft Degeneration: A Retrospective Cohort Analysis
Objective: The Intermountain Risk Score (IMRS), derived from routine laboratory parameters, predicts cardiovascular outcomes. Its association with saphenous vein graft degeneration (SVGD) post-coronary artery bypass grafting (CABG) remains underexplored. Methods: This retrospective cohort study…
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Artikel Jurnal
Anatomical Variability of the Proximal Femur: A Morphometric Study Relevant to Orthopedic Implant Design
Objective: Proximal femur morphometry plays a crucial role in fracture management and hip arthroplasty by affecting implant fit, biomechanics, and surgical outcomes. Therefore, the utilization of anatomical data reflecting inter-individual variability is essential for optimizing implant design and…
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Artikel Jurnal
CDH1 Gene Promoter Polymorphism and the Risk of Gastric Cancer: A Meta-Analysis
Objective: CDH1 polymorphism has been suggested to be associated with susceptibility to gastric cancer (GC). However, relevant findings remain inconsistent across studies. This meta‑analysis was performed to evaluate the relationship between CDH1 −160C/A and −347G/GA polymorphisms and GC risk…
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Artikel Jurnal
Dual Targeting Strategy: Colchicine and Paclitaxel Combination Against Prostate Cancer Cells Colchicine-Paclitaxel Synergy in Prostate Cancer
Objective: Prostate cancer is the leading male malignancy. Despite therapeutic advances, drug resistance remains a major obstacle, leading many patients to develop castration-resistant prostate cancer. This study investigates the combined effects of the microtubule-targeting agents colchicine and…
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Artikel Jurnal
Exploring the Link Between Bacterial Biofilm and Disease Severity in Cholesteatoma-Associated CSOM
Objective: Chronic suppurative otitis media (CSOM) with cholesteatoma is a potentially dangerous condition that can lead to extracranial and intracranial complications. Bacteria associated with CSOM cholesteatoma frequently produce biofilms, which contribute to antibiotic resistance and accelerate…