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Animal Cells and Systems
Scopus
ISSN 2151-2485 · Taylor & Francis Group · 410 artikel di indeks
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Artikel Jurnal
Quercus infectoria gall extract modulates adipocyte differentiation and lipid metabolism through dual regulation of adipogenesis and lipolysis in 3T3-L1 adipocytes
Quercus infectoria galls (QIG), traditionally used in Asian and Middle Eastern medicine, have shown lipid-lowering activity by reducing cholesterol, triglycerides, and low-density lipoprotein (LDL) levels. However, their role in regulating adipocyte lipid metabolism remains unexplored. This study…
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Predictive modeling of animal-vehicle collisions involving the threatened leopard cat (Prionailurus bengalensis) and Eurasian otter (Lutra lutra), in the Republic of Korea
Animal-vehicle collisions (AVCs) substantially contribute to wildlife population decline and adversely impact threatened species with already limited numbers. In this study, we aimed to investigate the factors contributing to AVCs involving two threatened species in the Republic of Korea: the…
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Evolutionary insights from complete mitochondrial genomes of Aedes albopictus and Culex pipiens molestus (Diptera: Culicidae)
Mitochondrial genomes (mitogenomes) are powerful molecular tools for exploring phylogenetic relationships, deciphering adaptation and divergence, as well as disease transmission potential among insects. In this study, we performed a comparative mitogenomic and phylogenetic analysis of two major…
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Genome-wide detection of fine-scale population stratification and long-distance dispersal of the Chinese mitten crab (Eriocheir sinensis)
Understanding the population genetic structure of marine decapods is essential for their effective conservation and management, particularly for species like the Chinese mitten crab (Eriocheir sinensis), which exhibits a complex life cycle and high invasive potential. In this study, we applied a…
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Artikel Jurnal
MicroRNA-mediated mechanotransduction and chondrocyte differentiation in mesenchymal stem cells
Mesenchymal stem cells (MSCs) integrate mechanical information from their microenvironment to regulate lineage commitment. Through integrin-based adhesion, cytoskeletal tension, and nuclear deformation, mechanical cues are transduced into intracellular signals via conserved pathways such as…
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Proteomics and phosphoproteomics of human colorectal cancer cells lacking a specific kinase activity reveal kinase-specific compensatory responses
Cell signaling regulates cell proliferation, survival, and migration, and abnormal kinase activity is often implicated in cancer. Although kinases are key targets for anticancer therapy, drug-induced compensatory signaling and pathway rewiring often drive acquired resistance. These compensatory…
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Tetramethylthiuram disulfide induces stress granules and DNA damage through oxidative stress in human lung epithelial cells
Tetramethylthiuram disulfide (TMTD), widely used in rubber manufacturing and agriculture, presents occupational inhalation hazards, yet its effects on human lung epithelial cells remain poorly characterized. Here, we investigated TMTD-induced cellular stress responses in A549 lung epithelial cells…
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Artikel Jurnal
Notch signaling in leech neurogenesis: expression patterns and functional insights in the Glossiphoniid leech Helobdella austinensis
The Notch signaling pathway is one of the most evolutionarily conserved pathways, playing a crucial role in juxtacrine signaling between adjacent cells. Although previous studies have characterized Notch signaling in diverse models, its function in the lophotrochozoan animals is largely not…
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From threatened to widespread: a non-genuine conservation status update for a now widespread Asian Hylid
Non-genuine conservation status updates threaten the trust in Red Listing, but they are necessary building blocks in science. In addition, they often highlight the critical need for basic field research. The Suweon treefrog, Dryophytes suweonensis, is a hylid species long thought to be…
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Artikel Jurnal
The double-edged sword of regulatory T cells in MASLD: from inflammation control to fibrosis promotion
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its advanced inflammatory subtype, metabolic dysfunction-associated steatohepatitis (MASH), are becoming increasingly prevalent liver disorders driven by complex interactions between metabolic stress, immune dysregulation, and…
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Artikel Jurnal
ATP release mediated by TRPM3 enhances invasion in glioblastoma
Glioblastoma (GBM) is the most aggressive and lethal form of primary brain tumor, characterized by uncontrolled proliferation and invasion into surrounding brain tissue. Mechanical stimulation (MS) in the tumor microenvironment (TME) has been correlated to tumor progression, partly via ATP release…
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Artikel Jurnal
Integrated morphological and transcriptomic analysis of sucker development in Octopus minor
Coleoid cephalopods are excellent models for evolutionary and developmental studies due to their centralized nervous system, short life span, and sophisticated sense organs. Arm suckers, essential for predation, manipulation, and locomotion, have been studied in Decapodiformes, but little is known…
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Artikel Jurnal
Long non-coding RNAs in the exosomal network: dual roles and clinical implications in cancer
Exosomes are a type of extracellular vesicles with a diameter of 30–150 nm, formed within multivesicular bodies of late endosomes, and released into the extracellular environment before being taken up by recipient cells. Exosomes transfer bioactive molecules, such as proteins and various RNAs…
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Artikel Jurnal
Dual antidiabetic potential of arjunglucoside I and arjunetin from Terminalia chebula via modulation of insulin- and gluconeogenesis-related responses
A deciduous tree belonging to the Combretaceae family, Terminalia chebula Retz. has a long history of traditional use in diabetes management. However, it is not fully understood how the extract of T. chebula exerts the antidiabetic effects. To identify the constituents responsible for this…
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Artikel Jurnal
Calcium hydroxyapatite suppresses extracellular matrix-related gene expression by modulating Piezo1-associated Ca2+ signaling and PKA activity
Fibrosis is characterized by excessive extracellular matrix (ECM) deposition driven by sustained pro-fibrotic signaling and underlies a wide range of pathological conditions. Accordingly, strategies that broadly suppress ECM production are considered promising for the treatment of fibrosis…
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Artikel Jurnal
CD71 defines functionally active spermatogonial stem cells with enhanced transplantation potential in mouse testes
Spermatogonial stem cells (SSCs) are responsible for lifelong spermatogenesis in adult males; however, their scarcity and inherent heterogeneity, coupled with the lack of robust SSC-specific surface markers, continue to impede isolation and characterization. In the present study, we found CD71…
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De novo whole transcriptome sequencing reveals differentially expressed messenger RNA and MicroRNA in hepatopancreas of Pandalus hypsinotus
Pandalus hypsinotus (P. hypsinotus), also known as coonstripe shrimp, has high economic value and is widely distributed in Alaska, the Bering Sea and the East Sea of Korea. However, owing to the low catch rates and patchy spatial distribution, transcriptome-based studies on this species remain…
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Comparative phylotranscriptomics reveals glycolytic adaptation associated with prolonged larval development in the coastal slipper lobster Crenarctus bicuspidatus
The molecular basis of ecological adaptation in marine crustaceans remains poorly understood, particularly in non-model species such as the coastal slipper lobster (Crenarctus bicuspidatus). This study presents the first comprehensive analysis of the mitochondrial genome and transcriptome of C…
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Artikel Jurnal
Manic switching from depression is affected by adult hippocampal neurogenesis
Many individuals who initially present with depression later develop manic or hypomanic episodes, yet the biological processes accompanying this delayed shift remain unclear. Here, we examined whether perturbation of the adult hippocampal neurogenic niche is associated with time-dependent shifts in…
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Enhancer RNA-mediated transcriptional regulation of TDP-43 during early neural lineage specification
TAR DNA-binding protein 43 (TDP-43) is a DNA- and RNA-binding protein that regulates gene expression by modulating transcription and RNA processing. It plays pivotal roles in neuronal development and function, and its mislocalization and aggregation are major pathological features of several…