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Translational Psychiatry
Scopus
ISSN 2158-3188 · Nature Publishing Group · 3,173 articles in the index
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Journal Article
The effects of sub-chronic calcium treatment on ethanol-induced dopamine elevation and the alcohol deprivation effect in the rat
Abstract Alcohol use disorder (AUD) is a serious mental health condition and a risk factor for morbidity and preterm death. The drug acamprosate (Campral® – calcium-bis[N-acetylhomotaurinate]) is one of few pharmacological treatments available for AUD. Recent research suggests that the properties…
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Journal Article
A community screening tool for neuropsychiatric symptoms in the elderly: integrating cortisol, microbiome, and social factors with machine learning
Abstract Neuropsychiatric symptoms (NPS) are early indicators of cognitive decline due to neurodegenerative diseases, and their timely detection is of the utmost importance. We aimed to develop and validate methods for large-scale NPS screening among elderly individuals and explore underlying…
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Journal Article
Impairment in stimulus-response learning as a cognitive biomarker in a model of synucleinopathy
Abstract Translating findings from preclinical assessments of cognitive function relevant to synucleinopathies into successful clinical trials poses significant challenges. In this study, we examined the effectiveness of human-relevant touchscreen cognitive assessments in detecting the impact of…
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Journal Article
Multimodal neuroimaging reveals brain neurochemical disturbances associated with superoxide dismutase in first-episode drug-naïve schizophrenia
Abstract Reduced antioxidant defense observed in first-episode drug-naïve schizophrenia (SCZ) may contribute to impaired cognition of SCZ. However, the underlying relationships among antioxidant stress-neuroimaging-cognition pathway and neurotransmitter dysfunction remain unclear. In this study, 75…
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Journal Article
Uncovering oscillatory dysregulation associated with suicide risk in major depressive disorder: a narrative review
Abstract Neural oscillations have emerged as critical markers of cognitive and emotional states, offering valuable insights into psychiatric disorders. Given the potential suicide risk in patients with major depressive disorders (MDD), its underlying neurophysiological associations need to be…
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Journal Article
Perceived control as a resilience factor: associations with neural, physiological and affective stress responses and mental health
Abstract Perceived control is a key mechanism implicated in stress resilience. A tendency to perceive control over stressors may protect individuals against negative outcomes across various situations by increasing active coping and preventing exacerbated stress reactions. Assuming that individual…
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Journal Article
Three years of medication-use sequences in incident bipolar disorder in Sweden reveal divergent patterns in native-born and immigrant populations
Abstract Guideline-conform treatment of mental disorders is compromised in immigrant populations, but longitudinal pharmacoepidemiologic patterns in bipolar disorder (BD) remain unknown. We aimed to close this knowledge gap by applying state sequence analysis (SSA) to comprehensively assess…
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Journal Article
Critical appraisal of a pilot study examining a ketogenic diet as an adjunct therapy in college students with major depressive disorder
Abstract Major depressive disorder (MDD) remains a leading cause of disability worldwide, and innovative adjunctive strategies are needed to enhance treatment outcomes. This critical appraisal examines a recent pilot study by Decker et al., which evaluated a 10–12 week well-formulated ketogenic…
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Journal Article
Using multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with cognitive performance
Abstract Cognitive performance has been found to be associated with the complex structure of human cerebral cortex. However, due to the limitations of previous cortical parcellation atlases, the cortical genetic patterns determining cognitive performance remain unknown. Here, we utilized the latest…
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Journal Article
Contactless depression screening via facial video-derived heart rate variability
Abstract Depression is a prevalent mental health condition that frequently remains undiagnosed, highlighting the need for objective and scalable screening tools. Heart rate variability (HRV) has emerged as a potential physiological marker of depression, and facial video-based HRV measurement offers…
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Journal Article
Cytokine changes in clinical high risk for psychosis population following antipsychotic medication
Abstract Serum cytokine alterations are associated with the usage of antipsychotic medications (AP). However, few studies have been designed to longitudinally measure cytokine changes during AP exposure in individuals at clinical high risk (CHR) for psychosis. This study aimed to assess changes in…
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Journal Article
Plasma short-chain fatty acid concentrations in social anxiety disorder and changes after cognitive behavioral therapy
Abstract Emerging evidence indicates that the gut microbiota are linked to variation in social behavior and anxiety, with short-chain fatty acids (SCFAs) proposed as key microbial metabolites that may mediate microbiota-brain communication. Cognitive behavioral therapy (CBT) is an effective…
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Journal Article
Social valence dictates sex differences in identity recognition
Abstract Social valence is the directional emotional significance affiliated with social experiences. Maladaptive social information processing has been linked to mood disorder susceptibility, which is more prevalent in women. To determine whether there are sex differences in social valence…
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Journal Article
Time matters for metas: a systematic review and meta-analysis of ect vs ketamine for depression incorporating time
Abstract Importance Comparing treatments for severe and medication-resistant depression is essential for guiding clinical decision-making. Objective In this meta-analysis, we investigate the efficacy of electroconvulsive therapy (ECT) compared to ketamine for the treatment of major depressive…
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Journal Article
Early functional changes and plasma GFAP in Swedish families with Autosomal Dominant Alzheimer’s disease mutations
Abstract We aimed to understand longitudinal associations between Alzheimer’s disease (AD) biomarkers in Autosomal Dominant AD (ADAD) across estimated years to symptom onset (EYO). Forty-five individuals (19 mutation carriers [EYO = −7.9 ± 11.7 years, APP N = 11; PSEN1 N = 8]) from Swedish ADAD…
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Journal Article
Acute effects of selective serotonin reuptake inhibitors on cerebral glucose metabolism and blood flow
Abstract Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed antidepressants, though their mechanisms of action beyond serotonin transporter (SERT) blockade remain unclear [1]. As previous work on BOLD signal changes remain equivocal, pharmacological multimodal neuroimaging of…
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Journal Article
Functional heterogeneity in non-suicidal self-injury across psychiatric disorders: neural and psychosocial correlates
Abstract Non-suicidal self-injury (NSSI) is a common behavior among adolescents, particularly within psychiatric populations. While neurobiological and psychosocial risk factors have been extensively studied, the mechanisms underlying NSSI’s heterogeneity remain unclear. This study investigated 304…
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Journal Article
Immediate and long-term effects of orbitofrontal cortex stimulation on EEG microstates in schizophrenia
Abstract Repetitive transcranial magnetic stimulation (rTMS) targeting the orbitofrontal cortex (OFC) has shown promise in treating schizophrenia, yet its immediate and long-term effects on brain dynamics remain unclear. This study investigated the electrophysiological impact of OFC-rTMS by…
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