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Brain and Behavior
Scopus
ISSN 2162-3279 · Wiley · 3,781 articles in the index
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Journal Article
Adaptogenic Effects of Mushroom Blend Supplementation on Stress, Fatigue, and Sleep: A Randomised, Double‐Blind, and Placebo‐Controlled Trial
ABSTRACT Background/Objectives: Medicinal mushrooms have been gaining increasing attention as functional foods; however, scientific evidence from human studies remains limited. Methods: In this study, 50 participants were randomly assigned to receive either Restake or a placebo. Psychological and…
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Journal Article
Distinct Gut Microbiota Profiles Reflect Severity in Chronic Insomnia Disorder
ABSTRACT Introduction Severe insomnia symptoms increase the risk of persistent sleep disorders, underscoring the need for timely identification to optimize therapeutic interventions. Given the established association between chronic insomnia disorder (CID) and gut microbiota, this study aimed to…
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Journal Article
Rehabilitation–Cognition Integrated Care Program for Elderly With Lower Limb Fractures and Cognitive Impairment: Development and Efficacy
ABSTRACT Objective To develop and assess the efficacy of a rehabilitation–cognition integrated care (RCIC) program for elderly patients with lower limb fractures and mild‐to‐moderate cognitive impairment. Methods A total of 128 eligible patients during January 2023 to December 2024 were randomly…
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Journal Article
Mapping the Scientific Landscape of Schizophrenia Genetics (2020–2025): A Bibliometric and Scientometric Study of Global Trends and Collaborations
ABSTRACT Background and objective This study provides a comprehensive bibliometric and scientometric analysis of research trends in schizophrenia genetics from 2020 to 2025. Driven by rapid technological advances such as genome‐wide association studies (GWAS) and next‐generation sequencing (NGS)…
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Journal Article
Prediction Models for Acute Kidney Injury in Stroke Patients: A Systematic Review
ABSTRACT Introduction To systematically identify and synthesize the research on prediction models for acute kidney injury (AKI) in stroke patients. Methods: CNKI, Wanfang, VIP, CBM, PubMed, Cochrane Library, Embase, and Web of Science were searched from inception to April 26, 2025. The fundamental…
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Journal Article
Case–Controlled Clinical Assessment of the Olfactory System via Cranial Magnetic Resonance Imaging in Patients With Type 2 Diabetes Mellitus
ABSTRACT Objective The purpose of this study is to assess the olfactory system of patients with T2DM using the cranial magnetic resonance imaging (MRI) method. Method This is a retrospective case–control study in which a group of T2DM patients and a control group were compared. The results of the…
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Journal Article
L‐Quebrachitol Enhances Sedative Effect of Diazepam Through GABAergic Pathway: Animal and Computational Studies
ABSTRACT Introduction Insomnia and other sleep disorders are becoming increasingly prevalent worldwide, while current sedative medications such as benzodiazepines, though effective, are often limited by side effects and dependency risks. Therefore, identifying safe natural compounds with sedative…
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Journal Article
Mobile Phone Addiction and Academic Procrastination in Adolescents: The Serial Mediating Roles of Self‐Regulation and Psychological Resilience and the Moderating Role of the Parent‐Child Relationship
ABSTRACT Background Mobile phone addiction and academic procrastination are two common behavioral challenges among adolescents. While prior research has documented their association, the underlying mechanisms—particularly the mediating roles of self‐regulation and psychological resilience and the…
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Journal Article
Cerebral Small Vessel Disease Burden in Acute Ischemic Stroke and the Role of Physical Activity: Cross‐Sectional Study
ABSTRACT Background Cerebral small vessel disease (cSVD) is a major cause of stroke and cognitive decline. While classical cardiovascular risk factors are well‐established contributors to overall cSVD burden, the effect of physical activity (PA) is not fully understood. This study aims to…
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Journal Article
Long‐Term Trends in Parkinson's Disease and Associated Mental Health Disorders: Insights From the CDC WONDER Database, 1999–2023
ABSTRACT Background The U.S. population is aging with an increasing burden of Parkinson's disease (PD) and its frequent co‐occurring mental health disorders. However, mortality trends related to PD and these comorbid mental health disorders among older adults remain understudied. Objective To…
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Journal Article
Prior Knowledge of Epilepsy Predicts Positive Attitudes and Practices Toward Persons Living With Epilepsy
ABSTRACT Background Epilepsy‐associated misconceptions may put persons living with epilepsy (PLWE) at risk of developing psychological disorders, resulting in a decrease in social contact. Purpose Understanding knowledge, attitude, and practice (KAP) about epilepsy is essential in developing…
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Journal Article
Translation and Validation of the Thai Version of the Telephone Interview for Cognitive Status and the Mini Montreal Cognitive Assessment in Older Adults
Abstract Introduction This study aimed to translate and validate the telephone interview for cognitive status (TICS) and the mini montreal cognitive assessment (Mini MoCA) for use in older Thai adults and to compare their diagnostic validity for mild cognitive impairment (MCI) and dementia…
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Journal Article
Risk Factors of Caregiver Burden in Patients With Cognitive Dysfunction: A Scoping Review
Abstract Introduction To synthesize the risk factors of caregiver burden in patients with cognitive dysfunction and provide insights for clinical nursing practice and research. Methods A scoping review was conducted following the five‐stage methodological framework proposed by Arksey and O'Malley…
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Journal Article
Cortically Dependent Motor Training Does Not Induce Abnormal Movements in DYT1‐Knock In Mice
ABSTRACT Purpose DYT1 dystonia is the most common inherited dystonia, but mouse models recapitulating the human genotype do not exhibit overtly dystonic movements. Because cortical and striatal plasticity are implicated in dystonia pathogenesis, we hypothesized that repetitive performance of a…
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Journal Article
UMI‐77 Ameliorates Lipopolysaccharide‐Induced Sepsis‐Associated Encephalopathy by Modulating the Brain‐Gut Axis
Abstract Purpose Sepsis‐associated encephalopathy (SAE) is a common neurological complication of sepsis. UMI‐77 has shown unique benefits in modulating inflammation to improve sepsis. However, the exact role of UMI‐77 in the treatment of SAE and its mechanism are unknown. Aim This article analyzes…
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Journal Article
Targeting the Spinal Cord‐Brain Axis: Electroacupuncture Mitigates Remote Frontal Cortex Neuroinflammation via HMGB1/TLR4 to Aid Functional Recovery After Spinal Cord Injury
Abstract Background Beyond the primary lesion, spinal cord injury (SCI) induces secondary neuroinflammation in the frontal cortex, a critical factor exacerbating neural damage and impeding functional recovery. This remote inflammatory response is predominantly regulated by the HMGB1/TLR4 signaling…
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Journal Article
Measuring the Subjective Signal Strength: Validating Persian Vividness of Visual Mental Imagery Questionnaire‐2
ABSTRACT Introduction Although visual mental imagery has been widely researched, a lack of valid measures in Persian‐speaking populations has limited cross‐cultural, developmental, and clinical research on imagery vividness and its role in reality monitoring. Methods We translated, culturally…
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Journal Article
The Role of Sphingolipid Metabolism and Neuron Death in Ischemic Stroke: A New Perspective from Bioinformatics
ABSTRACT Background Ischemic stroke (IS) is a leading cause of death and disability worldwide, but traditional risk factors do not fully explain its pathophysiology. Neuronal death in IS is influenced by multiple pathways, including sphingolipid metabolism, which plays a significant role in…
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Journal Article
Research Progress of Ferroptosis in Cerebral Infarction
ABSTRACT Purpose: To synthesize current mechanistic insights and translational progress on ferroptosis, a regulated, iron‐dependent, nonapoptotic cell death pathway in the pathophysiology and treatment of cerebral infarction (ischemic stroke), and to outline therapeutic opportunities and remaining…
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Journal Article
Five‐Decade Mortality Trends in Ischemic Stroke in the United States: A CDC WONDER Analysis
ABSTRACT Introduction Ischemic stroke, comprising nearly 85% of all strokes, remains a leading cause of death and disability worldwide. Annually, about 795,000 individuals in the United States (US) experience a new or recurrent stroke. Despite advancements in diagnosis, treatment, and prevention…
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