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Adipocyte
Scopus
ISSN 2162-397X · Taylor & Francis Group · 336 articles in the index
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Journal Article
Physical differentiation of adipose-derived mesenchymal stem cells into pancreatic beta-like cells using cell-imprinting and evaluation of insulin production
Stem cell-based therapies are emerging as a promising treatment for diabetes by differentiating these cells into insulin-producing cells (IPCs). However, using growth factors for differentiation has always been challenging. Physical differentiation of stem cells presents a promising approach to…
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Journal Article
Lack of receptor for advanced glycation end products attenuates obesity-induced adipose tissue senescence in mice
The receptor for advanced glycation end products (RAGE) and its ligands are critical drivers of adipose tissue inflammation. While RAGE expression increases in ageing cells and pathological conditions, its specific role in high-fat diet (HFD)-induced adipose tissue senescence remains to be fully…
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Journal Article
Assessment of the safety and efficacy of sodium pentaborate pentahydrate in individuals with overweight and obesity: a randomized, double-blind, placebo-controlled, phase 1/2 dose-finding trial
The present study aimed to examine the short-term safety and tolerability of sodium pentaborate pentahydrate (NaB) and to explore preliminary efficacy and dose selection as secondary objectives in individuals with overweight or obesity. In this randomized, double-blind, placebo-controlled, phase…
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Journal Article
Super-enhancer-associated miR-1260b coordinates adipogenesis and metabolic programming in human adipose stem cells
Obesity and its metabolic complications represent a major and growing public health burden, for which effective therapeutic strategies remain limited. Although super-enhancers are recognized as key regulators of cell identity and adipogenesis, the roles of super-enhancer– microRNAs in obesity and…
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Journal Article
An acute temperature rise to 40°C inhibits free fatty acid uptake into white adipocytes
Fever reflects a physiological rise in body temperature accompanied by elevated production of adrenaline. The increased body temperature in fever is caused by shivering thermogenesis in skeletal muscle and non-shivering thermogenesis in brown adipose tissue (BAT), the latter being mediated by…
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Journal Article
Pharmacological inhibition of CLPP stabilizes LETMD1 to boost thermogenesis and alleviate obesity
Obesity poses a severe global health burden, and activating adipose thermogenesis offers a promising therapeutic avenue. However, the contribution of mitochondrial proteostasis to thermogenic regulation remains elusive. Here, we identify mitochondrial protease CLPP as a negative regulator of…
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Journal Article
The extracellular matrix protein SNED1 affects self-renewal, proliferation and adipogenic differentiation of human adipose stem/progenitor cells
The fate of adipose stem/progenitor cells (ASCs) is influenced by the extracellular matrix (ECM). However, the interaction between ASCs and components of the ECM in human white adipose tissue (WAT) is not precisely understood. The gene Sushi, nidogen and EGF-like domain-containing protein 1 (SNED1)…
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Journal Article
Multi-omics integration reveals convergent extracellular matrix remodelling and lipid metabolic reprogramming as central axes of adipocyte differentiation from mouse embryonic stem cells
Adipogenesis from mouse embryonic stem cells (mESCs) offers a tractable model for dissecting early adipocyte commitment, yet the mechanisms coordinating this transition across multiple biological layers remain incompletely understood. Here we present the first simultaneous five-layer multi-omics…
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Journal Article
When LXA4 meets white fat: browning via the miR-133a-3p/SIRT1 pathway in mouse models
Given the established positive role of Lipoxin A4 (LXA4) in adipose browning at the cellular level, this study investigated its possible effect on white fat browning and the underlying molecular mechanisms. The obese insulin resistance mouse model was established. The body weight, subcutaneous and…
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Journal Article
Normalized periprostatic adipose tissue thickness: an imaging marker associated with prostate biopsy outcomes among patients with PI-RADS and PSA double gray zone
Periprostatic adipose tissue (PPAT) is a potential factor closely associated with prostate cancer (PCa) development. This study aimed to introduce normalized PPAT thickness, a novel imaging biomarker, as a PCa predictor for patients within the diagnostic ‘double gray zone’, defined as the…
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Journal Article
Autofluorescence profiles define depot-specific adipocyte phenotypes in perivascular and non-perivascular adipose tissue
Perivascular adipose tissue (PVAT) is recognized as the functional fourth layer of the vasculature. Unlike non-PVAT depots, PVAT is continuously exposed to haemodynamic forces, potentially altering the morphometry of its adipocytes. While transcriptomics studies have identified diverse adipocyte…
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Journal Article
Lipedema and obesity: biological interactions, diagnostic challenges, and principles of interdisciplinary management – a narrative review
Lipedema and obesity are chronic, frequently progressive disorders that can present with increased adipose-tissue volume, functional impairment and reduced quality of life. Although often approached as differential diagnoses, they frequently coexist and may aggravate one another. This narrative…
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Journal Article
β2-adrenergic receptor stimulation drives differentiation of human adipose-derived mesenchymal stem cells into beige adipocytes
β-Adrenergic receptors (β-ARs) drive the induction of beige adipocytes in rodents and humans, yet the dominant human subtype, β2-AR or β3-AR, remains debated. This study aimed to confirm whether human adipose-derived mesenchymal stem cell (hADSCs)-derived adipocytes can serve as a beiging-competent…
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Journal Article
Depot-specific differences in visceral and subcutaneous adipose tissue from patients with obesity
Factors limiting fat cell expandability remain scarcely explored, and comprehensive functional comparisons of adipose depots in humans are limited. In the present study, we collected visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) paired-samples from 22 patients with obesity…
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Journal Article
Role of adiponectin in gestational diabetes mellitus: advances in mechanistic insights and early predictive potential
Gestational diabetes mellitus (GDM) is a common metabolic complication of pregnancy and is associated with an increased risk of short-term adverse maternal and neonatal outcomes, as well as long-term metabolic disorders in both mothers and offspring. Exacerbated insulin resistance and inadequate…
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Journal Article
Twf1 regulates adipocyte proliferation and differentiation through Yap nucleus accumulation
Obesity involves white adipose tissue (WAT) expansion via hyperplasia and hypertrophy. Impaired adipocyte proliferation leads to pathological hypertrophy, inflammation and metabolic dysfunction. Aberrant F‑actin turnover disrupts proliferation/differentiation. Twinfilin‑1 (Twf1) regulates actin…
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Journal Article
The adiponectin/leptin ratio as a biomarker of adiposopathy and visceral adipose tissue accumulation: sex-specific mechanisms
Adipose tissue (AT) dysfunction can lead to increased visceral AT (VAT) and metabolic damage. The adiponectin/leptin ratio (ALR) has been proposed as a biomarker of AT functionality. However, its participation in VAT accumulation and the impact of sex on these associations have not been evaluated…
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Journal Article
The transcription elongation factors Spt4 and Spt6 promote dermal adipocyte differentiation
Regulation of adipogenesis has classically been viewed through the lens of transcription initiation driven by lineage defining transcription factors. In this study, we uncover transcription elongation as a critical and previously underappreciated regulatory layer controlling adipocyte cell fate. We…
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Journal Article
Hypotonic induced volume activated chloride current in 3T3-L1 preadipocytes and its effect on cell differentiation
Volume-activated chloride current (VACC), the most common and abundant anion current in organisms, is involved in various physiological and pathological processes. However, its expression and characteristics in preadipocytes remain unclear. Whole-cell patch clamp technique was used to investigate…
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Journal Article
Erianin inhibits 3T3-L1 adipocyte differentiation through downregulation of CCAAT-enhancer binding protein-α and peroxisome proliferator-activated receptor-γ, lipogenic genes and impairment of mitochondrial respiration
Erianin, a natural bibenzyl compound, has recently garnered attention owing to its diverse biological activities. In the present study, we investigated the effects of Erianin on adipocyte differentiation, lipid metabolism, and mitochondrial respiration in murine 3T3-L1 cells. Cytotoxicity assays…