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Brazilian Journal of Pharmaceutical Sciences
Scopus
ISSN 2175-9790 · Universidade de São Paulo, Faculdade de Ciências Farmacêuticas · 1.969 artikel di indeks
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The State of the Art in Evolocumab Treatments for Hypercholesterolemia Based on Technological Prospecting
This study used the technological prospecting of scientific databases and applied patent documents toexamine the state of the art in evolocumab (EVO) treatments for hypercholesterolemia. This strategyprovides a middle ground between two approaches to technological prospecting: the retrieval of…
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Institutionalized elderly: real and potential drug interactions
To understand, investigate and prevent drug interactions in institutionalized elderly enable planning actual actions to promote healthy and safety treatments to elderly people. The present study sought to analyze potential and real drug interactions in institutionalized elderly. This is an…
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Technological prospection of extracts, fractions and plant isolates for the treatment of glioblastoma
Glioblastoma is an aggressive primary brain cancer with high lethality and low survival rates, even after standard multimodal treatment involving surgical resection, chemotherapy, and radiotherapy. In this context, natural products emerge as a promising source of bioactive with antitumor…
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Evaluation of release enhancement of efavirenz through poloxamer solid dispersions
Poloxamers are triblock copolymers commonly used in pharmaceutical formulation development to enhance the solubility of poorly water-soluble compounds. The present study investigated the efficiency of the hydrophilic carriers, poloxamer 188 (P188) and poloxamer 407 (P407), in preparing solid…
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Comparative Evaluation of Polymers for Fabrication of Mucoadhesive Tablets: Impact on Mucoadhesion Properties and In-vitro Drug Release
This study explores the effect of various polymers on drug release and mucoadhesion, using miconazole as a model drug. Tablets were prepared with polymers such as Eudragit RS, hydroxypropyl methylcellulose (HPMC), carbomer 940, cress seed gum (CSG), basil seed gum (BSG), carrageenan (CAR), and guar…
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Cyanidin-3-O-Glucoside alleviates atopic dermatitis and depression-like behavior by modulating immune cells in DNFB-induced mice
Atopic dermatitis (AD) significantly impacts individuals’ daily lives. Patients with AD typically exhibit depressive-like behavior. Cyanidin-3-O-glucoside (C3G) is extensively utilized to treat inflammatory conditions, but its beneficial effect on AD has not been reported. The present study aims to…
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Development of a coffee ground body scrub: evaluating stability and the effect of particle size
This study aimed to develop and evaluate a sustainable body scrub formulation using coffee powder, focusing on the effect of granulometric separation on physicochemical stability and sensory performance. Two formulations were prepared using coffee powder, one with granulometric separation and one…
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FRAMEWORK FOR EXTRACTABLE AND LEACHABLE STUDIES IN DRUG PRODUCT DEVELOPMENT: A CASE STUDY
Extractables and leachables are compounds released from pharmaceutical packaging that can contaminate finished drug products under normal storage conditions. These compounds can potentially impact the efficacy, safety, and quality of the drug product. Despite regulatory requirements for conducting…
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The Ecotoxicological Impacts of Carbamazepine: Environmental Contamination vs. Effects on Freshwater Aquatic Organisms
The global population is expected to surpass nine billion by 2050, resulting in increased resource consumption and environmental degradation. This raises concerns about environmental contamination, a topic highlighted since Rachel Carson’s Silent Spring (1962), which warned about Contaminants of…
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Protective effects of bromelain in LPS-induced acute lung injury
Acute lung injury (ALI) is a severe disease that can cause extensive lung damage and lead to death. Elevated levels of inflammatory cytokines and associated inflammation and oxidative damage irreversibly damage the lung tissue, leading to death. This study aimed to utilize the powerful antioxidant…
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Topical formulation with ascorbyl tetraisopalmitate and synthetic tripeptide, combined with facial muscle exercises
Facial aging involves natural processes such as bone resorption, subcutaneous volume loss, ligament laxity, and skin flaccidity. Currently, many aesthetic treatments are used to attenuate or delay the signs of facial aging, including facial exercises. They intend to improve skin elasticity, muscle…
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Exploration of phytochemicals and antihyperlipidemic effect of crateva religiosa bark: in vivo mechanistic approach for management of hyperlipidaemia
The work investigated the presence of phytochemicals and antihyperlipidemic potential of the ethanolic extract of Crateva religiosa (CRETE). The extraction yield was found to be highest with ethanol (15.81% w/w), followed by ethyl acetate (11.98% w/w) and very poor in hexane (3.05% w/w), using as…
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Pharmacotherapy follow-up in hiv-positive patients: impact on mental health and quality of life
Research on anxiety and its treatment among HIV-infected individuals is limited, despite its high prevalence. HIV-positive patients often consume many anxiolytic/hypnotic medications. Pharmacotherapeutic monitoring and multidisciplinary pharmaceutical intervention can improve treatment adequacy…
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Herbal Medicine Around the World: How Brazil, India, the USA, and Europe Regulate It
Herbal medicines (HM), derived from whole plants or their parts, play a crucial role in primary health care, with approximately Eighty percent of the global population relying on them. The World Health Organization (WHO) is tasked with establishing guidelines for their use, safety, and quality…
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Effects of sea buckthorn granules on the lungs of rats with chronic bronchitis: a study based on the P38 MAPK/P65 NF-ΚB signaling pathway
This study was conducted to explore the mechanism of Sea Buckthorn Granules (SBG) in treating chronic bronchitis (CB) in rats. The primary chemical components of SBG were identified using UPLC-Q-TOF-MS/MS. A rat model of CB was established through smoke inhalation combined with lipopolysaccharide…
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Metabolic and antioxidant parameters in the kidneys of rats treated with copaiba oil in cirrhosis induced by thioacetamide
This study evaluated the effects of copaiba oil on the kidneys of rats with cirrhosis induced by thioacetamide. Male Wistar rats were divided into four groups (n = 8), namely Control (C), Thioacetamide (TAA), Copaiba Oil (OC), and Thioacetamide + Copaiba Oil (TAA+OC). The biochemical and…
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Creation of ceftazidime-avibactam utilization evaluation standards to examine physician prescribing compliance: a retrospective study
A study was conducted to create drug utilization evaluation (DUE) standards for ceftazidime-avibactam (CZA) and evaluate CZA use at the First Affiliated Hospital of Bengbu Medical University, China, from May 26, 2020, to December 18, 2024. First, we organized an expert panel and created DUE…
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Simultaneous determination of venetoclax and obinutuzumab by LC-MS/MS and its application to pharmacokinetic drug interaction studies
A novel LC-MS/MS method was developed and validated for the simultaneous quantification of venetoclax and obinutuzumab in rat plasma and successfully applied to pharmacokinetic investigations in male wistar rats. Chromatography was performed on a Symmetry C18 column (150 x 4.6 mm, 3.5 µm) column…
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Recent advances in paclitaxel polymer nanomedicine delivery for cancer therapy
Paclitaxel (PTX) is a widely used anti-tumor drug in cancer therapy. However, its poor water solubility restricts its application in therapeutic procedures. Furthermore, the Cremophor® in the formulation can cause various side effects, leading to non-specific drug distribution in tumors and normal…
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Pɸ-mi-pa loaded PVA/HA electrospun nanofibers from a statistically designed experiment using machine learning algorithms
Bacteriophages, which infect bacterial cells, have a unique ability to reduce bacterial colonization, particularly in antibiotic-resistant biofilm infections. This study aims to fabricate optimized bacteriophage-loaded nanofibers composed of polyvinyl alcohol (PVA) and hyaluronic acid (HA) using…
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