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Journal of Cachexia, Sarcopenia and Muscle
Scopus
ISSN 2190-6009 · Wiley · 1.868 artikel di indeks
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Artikel Jurnal
Direct AMPK Activation Confers Mutation‐Independent Therapeutic Benefit in Duchenne Muscular Dystrophy
ABSTRACT Background Duchenne muscular dystrophy (DMD) is a severe, life‐limiting neuromuscular disorder (NMD) characterized by progressive muscle wasting and mitochondrial dysfunction. Although gene therapies offer promise, even those already approved by regulatory agencies, their use remains…
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Artikel Jurnal
Association of Sarcopenia and Lower Bone Density With Positional Vertigo in the Morning: Insights From a Nationwide Survey
ABSTRACT Background This study aimed to identify associations of sarcopenia, obesity and low bone mineral density (BMD) with morning positional vertigo (PV) and to examine whether these associations differ according to vestibular function status in a nationally representative sample of Korean…
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Artikel Jurnal
Skeletal Muscle Mass Modifies the Prognostic Impact of LDL Cholesterol in Chronic Heart Failure
ABSTRACT Background Dyslipidaemia is among the major risk factors for atherosclerotic cardiovascular disease. Paradoxically, higher cholesterol levels are associated with better survival in heart failure (HF) of any aetiology. Because cholesterol is an integral component of skeletal muscle…
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Artikel Jurnal
Temporal Dynamics and Bidirectional Longitudinal Association Between Physical Function and Depressive Symptoms in Older Adults
ABSTRACT Background Physical function decline and depression are major challenges of the rapidly growing older population. This longitudinal study aimed to investigate the bidirectional longitudinal association between physical function and depressive symptoms, which are poorly understood in older…
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Artikel Jurnal
Ellagic Acid Alleviates Abnormal Fat Reduction by Activating the RXRβ–PPARγ Pathways in a CT26 Tumour‐Induced Cachexia Mouse Model
ABSTRACT Background Cancer cachexia is a syndrome characterized by significant weight loss, particularly of adipose tissue, which negatively impacts patient survival. Pharmacological approaches to prevent this abnormal fat reduction remain poorly defined. This study investigated the potential of…
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Artikel Jurnal
Disruption of Nuclear‐Cytoskeletal Linkage by Coil‐1a LMNA Mutations in Emery–Dreifuss Muscular Dystrophy
ABSTRACT Background Emery–Dreifuss muscular dystrophy (EDMD) is a progressive genetic myopathy that mainly affects the muscles used for movement (skeletal muscles) and the heart (cardiac muscles). The disease is frequently associated with mutations in genes encoding nuclear envelope proteins, most…
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Artikel Jurnal
Cognitive Sarcopenia: Prevalence and the Risk for Mortality and Healthy Aging in the KORA‐Age Study
ABSTRACT Background Cognitive sarcopenia, defined by this study as the co‐existence of sarcopenia and cognitive impairment, has been frequently reported in older adults, while we hypothesize that the co‐existence increases the risk for adverse outcomes in the older general population. Methods This…
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Artikel Jurnal
The Clinical Impact of Sarcopenia and Delirium in Hospitalized Elderly Patients: An Analysis Using Muscle Ultrasound
ABSTRACT Background Sarcopenia and delirium are two highly prevalent clinical syndromes among hospitalized elderly patients, both independently associated with adverse outcomes such as increased risk of falls, disability and mortality. Although a correlation between sarcopenia and delirium has been…
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Artikel Jurnal
Risk Factors Associated With Sarcopenia in Patients With Chronic Kidney Disease: A Systematic Review and Meta‐Analysis
ABSTRACT Background Sarcopenia is an age‐related degenerative disorder characterized by a progressive decline in skeletal muscle mass, strength, and function with high prevalence in chronic kidney disease (CKD). Identifying clinical and epidemiological factors of sarcopenia in patients with CKD is…
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Artikel Jurnal
Physical Fitness and Physical Function in Patients With Fabry Disease: A Cross‐Sectional Multicentre Study
ABSTRACT Background Fabry disease (FD) is a rare, X‐linked lysosomal storage disorder affecting multiple organs, including the musculoskeletal system. The physical status of FD patients remains poorly characterized. This multicentre cross‐sectional study aimed to evaluate physical fitness and…
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Artikel Jurnal
Cancer Cachexia Prevalence Is Underestimated in Medical Records of Patients in a Regional Tertiary Hospital
ABSTRACT Background Widespread lack of awareness and limited real‐world prevalence evidence have impeded cachexia care and research. We hypothesized that healthcare professionals may identify the term cachexia, leading to International Classification of Diseases (ICD) coding for this term, with or…
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Artikel Jurnal
Body Composition in Resectable Non‐Small Cell Lung Cancer Patients With Preoperative Sarcopenia: A Propensity‐Matched Analysis
ABSTRACT Background Sarcopenia is a prognostic factor in patients with early‐stage non‐small cell lung cancer (NSCLC). Previous studies have focused on muscle loss, yet comprehensive body composition (BC) alterations in this population remain poorly characterized. This study aimed to delineate BC…
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Artikel Jurnal
The Reliability of Measuring Muscle Cross‐Sectional Area in Children Undergoing Treatment for Musculoskeletal Sarcoma
ABSTRACT Background Changes in musculoskeletal health and function are increasingly recognised as important long‐term consequences of treatment for malignant bone tumours in paediatric populations. Accurate and reliable assessment methods are critical for monitoring these changes during treatment…
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Artikel Jurnal
Enhanced Expression of IL32 mRNA in Skeletal Muscles in the Context of Head and Neck Carcinomas
ABSTRACT Background Cancer‐related sarcopenia (CRS) is a significant complication of head and neck carcinoma (HNC), characterised by muscle degeneration and poor clinical outcomes. Although various dietary and therapeutic interventions have been explored, most of them remain empirical, and the…
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Artikel Jurnal
Largely Distinct Post‐Translational Modifications Differentiate Skeletal Muscle Wasting Caused by Cancer, Dexamethasone and Aging
ABSTRACT Background Skeletal muscle wasting and weakness are prominent disease features. Originally considered to arise from common transcriptional changes, recent analyses demonstrated that different stimuli induce muscle wasting via largely distinct mRNA and protein changes. Methods Here, we…
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Artikel Jurnal
Mitochondrial Transporter ABCB10 Protects Against Doxorubicin‐Induced Respiratory Muscle Dysfunction Independent of Changes to Diaphragm Accumulation
ABSTRACT Background Doxorubicin (DOX) is a highly effective chemotherapeutic agent whose use can cause respiratory toxicity, increasing patient fatigue and negatively impacting quality of life and survival. These adverse effects occur due to diaphragm muscle mitochondrial accumulation of DOX, where…
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Artikel Jurnal
Asian Reference Values for Handgrip Strength, Gait Speed, Five‐Times‐Sit‐to‐Stand Test, Muscle Mass and Calf Circumference
ABSTRACT Background Handgrip strength, gait speed, Five‐Times‐Sit‐to‐Stand Test (FTSST) performance, skeletal muscle mass and calf circumference are important health outcomes, particularly useful for diagnosing sarcopenia. The aim of this study was to establish reference (normative) values for…
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Artikel Jurnal
Current Trends in Duchenne Muscular Dystrophy Research and Therapy: 3D Cardiac Modelling
ABSTRACT Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, presents a multifaceted challenge that affects both skeletal muscle function and cardiomyocyte homeostasis, causing progressive degeneration and life‐threatening cardiac complications by adolescence. Current treatments…
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Artikel Jurnal
Pulsed Electromagnetic Field Therapy for Mild‐to‐Moderate Knee Osteoarthritis: A Double‐Blind, Randomized, Placebo‐Controlled Clinical Trial
ABSTRACT Background Current treatments for knee osteoarthritis (OA) offer limited functional and structural improvements. Compared to age‐ and gender‐matched controls, patients with knee OA show a higher prevalence of muscle weakness, which negatively affects their ability to exercise—a key factor…
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Artikel Jurnal
The Effects of Soy Protein–Rich Meals on Muscle Health of Older Adults Are Linked to Gut Microbiome Modifications
ABSTRACT Background Sarcopenia is characterized by accelerated muscle mass and function loss in older adults. The role of nutritional interventions in sarcopenia is uncertain. This study investigates whether a soy protein–rich diet can enhance muscle health in older adults via gut microbiota…
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