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Heterocyclic Communications
Scopus
ISSN 2191-0197 · De Gruyter · 107 artikel di indeks
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Artikel Jurnal
Biological activity-informed synthesis of quinoline-derived chiral γ-nitroketones via a bifunctional squaramide
Chiral γ-nitroketone-derived pyrrolidine N-oxide (III) exhibited potent in vitro anti-tumor activity against three cancer cell lines: human breast carcinoma (MDA-MB-231), human colorectal carcinoma (SW-480), and murine colorectal carcinoma (CT-26), with IC50 values of 8.81 ± 0.12 μM, 9.07 ± 0.31…
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Artikel Jurnal
Sustainable synthesis and comprehensive biological & computational evaluation of pyrimidine derivatives
The rising prevalence of multidrug-resistant pathogens and the global burden of cancer necessitate the development of new therapeutic agents using sustainable, innovative approaches. Pyrimidine derivatives have attracted considerable attention due to their diverse biological activities, including…
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Artikel Jurnal
Recent advancement of succinate dehydrogenase inhibitors based on the natural product scaffold
In face of large-scale plant diseases, the control of chemical pesticides remained a fast, economical and effective method. The search for novel bioactive pesticide has long been a priority in crop protection for solve the plant pathogen resistance. Natural products and their derivatives have been…
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Artikel Jurnal
Synthesis and antifungal activity of norbornene derivatives containing thiourea group
To explore more potential fungicides with new scaffolds, 10 norbornene derivatives containing thiourea group were designed, synthesized and assayed for inhibitory activity against three plant pathogenic fungi. The preliminary antifungal assay suggested that the title derivatives showed moderate to…
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Artikel Jurnal
1,2,3-Triazole: an important scaffold in drug design and development
1,2,3-triazole represents a class of nitrogen-containing heterocyclics with a wide range of biological activity. The medicinal applications of 1,2,3-triazole derivatives, including antioxidant, antimicrobial, antiviral, anti-inflammatory, antitumor, and antihyperglycemic effects, have been…
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Artikel Jurnal
Synthesis of novel triazole hybrids with pyrene, fluorene, and biphenyl groups and evaluation of their antimycobacterial activity
The synthesis of 1,2,3-triazoles, which are acting as promising pharmacophores with strong biological activity, is the focus of our work. Three obscure streaks of hybrid molecules with a 1,2,3-triazole nucleus have been synthesized by us. Compounds are synthesized in two steps: first, an azide is…
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Artikel Jurnal
Synthesis, activity exploration, molecular docking, and affinity assessment of theophylline derivatives as inhibitors targeting IDO1
Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunomodulatory enzyme associated with tumor immune evasion, making it a promising target for cancer therapy. This study aimed to identify novel holo-IDO1 inhibitors with distinct structural scaffolds. A series of theophylline derivatives containing…
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Artikel Jurnal
Development of heterocyclic-based anticancer agents: A comprehensive review
This review article summarizes the role of heterocyclic compounds as anticancer drugs used against various human cancers, including doxorubicin, cisplatin, paclitaxel, and resveratrol, which are among the most effective therapeutic agents. Chemotherapy, a treatment modality, exerts its effects on…
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Artikel Jurnal
Structural simplification of the 3‐nitroimidazo[1,2‐a]pyridine antileishmanial pharmacophore: Design, synthesis, and antileishmanial activity of novel 2,4-disubstituted 5-nitroimidazoles
As part of our ongoing antileishmanial structure–activity relationship study, a structural simplification of the 3‐nitroimidazo[1,2‐a]pyridine ring to a 5-nitroimidazole moiety was conducted. A series of novel 2,4-disubsituted 5-nitroimidazole derivatives, including the 5-nitroimidazole analog of…
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Artikel Jurnal
Synthesis of imidazole derivatives in the last 5 years: An update
Imidazole and its derivatives possess remarkable versatility, finding applications in medicine, synthetic chemistry, and industry. This review explores the latest advancements observed over the last few years (2018–2022), focusing on diverse multicomponent reactions conducted under different…
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Artikel Jurnal
Gold-catalyzed synthesis of small-sized carbo- and heterocyclic compounds: A review
Research on gold catalysis has flourished over the last 20 years, and gold catalysts are now acknowledged as the “best choice” for a range of organic transformations. Gold complexes have emerged as promising candidates for this use in recent years because of their high reactivity, which enables…
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Artikel Jurnal
Synthetic and therapeutic review of triazoles and hybrids
Triazoles act as important pharmacophores in showing biological activity such as antibacterial, antifungal, antitumour/anticancer, anti-inflammatory activities. Literature review suggests that triazoles have been maximally used in carrying research related activities in reference to biological…
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Artikel Jurnal
Current progress in the synthesis of imidazoles and their derivatives via the use of green tools
Imidazoles have a unique position in heterocyclic chemistry as these constitute the basic framework of several bio-molecules. Thus, increasing research is being carried out on the synthesis of imidazoles and their derivatives, mainly because of the application of imidazoles in pharmaceutical and…
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Artikel Jurnal
Inorganic nanoparticles promoted synthesis of oxygen-containing heterocycles
Since many of the U.S. Food and Drug Administration (FDA)-approved medications contain oxygen-containing heterocyclic molecules, they have been discovered to be quite important. Moreover, over the past 10 years, the field of reusable nanocatalysts has expanded quickly. Therefore, the development of…
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Artikel Jurnal
Synthesis of a novel water-soluble pyridine dicarboxylate and its application in fluorescence cell imaging
A novel water-soluble substituted pyridine dicarboxylate containing a quaternary ammonium ion with potential applications in fluorescence cell imaging was synthesized and characterized. Remarkably, this compound exhibited water solubility in the absence of additional solubilizers, enabling direct…
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Artikel Jurnal
Synthesis of novel meta-diamide compounds containing pyrazole moiety and their insecticidal evaluation
A novel series of meta-diamide compounds incorporating a pyrazole moiety (2a–2v) were designed and synthesized based on cyproflanilide. Their structures were validated through 1H NMR, 13C NMR, and HRMS analyses. These compounds were evaluated for their insecticidal activity against Plutella…
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Artikel Jurnal
Design, synthesis, biological evaluation, and bio-computational modeling of imidazo, thieno, pyrimidopyrimidine, pyrimidodiazepene, and motifs as antimicrobial agents
In the drug chemistry industry, synthesizing a talented exclusive series of aza-polyheterocyclic compounds was crucial. Aminopyrimidine nucleus reacted with two equivalents of benzaldehyde in the presence of KOH as a starting material to bring about imidazopyrimidine derivative, which experienced…
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Artikel Jurnal
Synthesis of a novel phosphate-containing ligand rhodium catalyst and exploration of its optimal reaction conditions and mechanism for the polymerization of phenylacetylene
Due to the chemical properties of Group VIII transition metals and their importance in catalytic processes, the reactions of rhodium and its neighboring organic complexes have received much attention as model systems. In the present experiments, we successfully prepared two new rhodium complexes…
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Artikel Jurnal
Synthesis and conformational analysis of N-BOC-protected-3,5-bis(arylidene)-4-piperidone EF-24 analogs as anti-cancer agents
Natural products and their analogs have been explored to stop the progression of cancer cells without unwanted side effects. Chalcones, compounds synthesized naturally in plants, have demonstrated potential as anti-cancer treatments. A library of bis-chalcones that are similar in structure to…