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ISSN 2191-0855 · SpringerOpen · 1.691 artikel di indeks
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Artikel Jurnal
Enhanced immunogenicity of Staphylococcus aureus IsdE vaccine with SeNPs and BCG adjuvants in mice
Abstract Staphylococcus aureus is a major cause of nosocomial infections and antimicrobial resistance, emphasizing the urgent need for an effective vaccine. The IsdE protein, a heme-iron transporter, has been identified as a promising antigen target. In this study, we evaluated the immunogenicity…
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Artikel Jurnal
Protective effects of Curcumin-Zinc complex on inflammatory damage of IPEC-J2 cells induced by bacterial lipopolysaccharide
Abstract The present study aimed to investigate the potential mitigative effects of the Curcumin-Zinc Complex (Cur-Zn) on bacterial lipopolysaccharide (LPS)-induced inflammatory damage in porcine small intestinal epithelial cells (IPEC-J2). IPEC-J2 cells were initially assigned to one of six…
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Artikel Jurnal
One-step detection of Chlamydia psittaci using recombinase polymerase amplification and CRISPR/Cas12b
Abstract The development of rapid, sensitive, and user-friendly diagnostic methods for Chlamydia psittaci (C. psittaci) is critical for early diagnosis and effective control of infections. Current techniques, such as qPCR and next-generation sequencing, face limitations in accessibility and…
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Artikel Jurnal
Heterologous expression of Thermomyces lanuginosus lipase in Aspergillus niger: stress resistance, optimization of fermentation conditions, and transcriptomic analysis
Abstract Aspergillus niger serves as a cell factory for efficient enzyme production. The lipase derived from Thermomyces lanuginosus (TLL) is known for its remarkable thermal stability and is extensively utilized in various industrial fields. In this study, a heterologous expression strain…
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Artikel Jurnal
Limosilactobacillus reuteri fermentation enhances the anti-type 2 diabetic activity of Gastrodia elata polysaccharides
Abstract The development of effective and low-toxicity treatments for type 2 diabetes mellitus (T2DM) remains a critical objective in current research. Lactic acid bacteria (LAB) fermentation can biotransform plant polysaccharides and may enhance their bioactivity. Here, we investigated the…
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Artikel Jurnal
Lactiplantibacillus plantarum P16 mitigated murine colitis through modulation of immune response and gut microbiota
Abstract Probiotics show potential for preventing and mitigating inflammatory bowel disease (IBD), though their efficacy and mechanisms are strain-specific. This study aimed to elucidate the protective mechanism of Lactiplantibacillus (L.) plantarum P16 against dextran sulfate sodium (DSS)-induced…
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Artikel Jurnal
Growth optimization and dual cellulolytic degradation pathways in Serpula lacrymans
Abstract Serpula lacrymans is the most destructive brown-rot fungus affecting timber in temperate regions, causing severe economic losses in construction and cultural heritage. Conventional chemical treatments are largely ineffective, as they act only on wood surfaces and fail to eradicate fungal…
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Artikel Jurnal
Myeloperoxidase-DNA complex: a marker and combined target for Pseudomonas aeruginosa-associated bronchiectasis
Abstract Pseudomonas aeruginosa (P. aeruginosa)-associated bronchiectasis remains a clinical challenge due to lacking diagnostic biomarkers and targeted therapies. This multi-dimensional (clinical-cell-animal) study investigated the myeloperoxidase (MPO)-DNA complex, a marker of neutrophil…
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Artikel Jurnal
Nano-chitosan modified restorative materials suppress Streptococcus mutans biofilm and virulence gene expression
Abstract Secondary caries and biofilm production remain a persistent concern, prompting the development of antibacterial restorative materials. However, worries about synthetic additives’ safety and long-term effects urge the use of natural, biocompatible alternatives. This study explored the…
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Artikel Jurnal
Hemoglobin expression reduces aerobic bioconversion of guaiacol in Pseudomonas putida despite non-limiting oxygen
Abstract Efficient lignin valorization relies on oxidative enzymatic reactions, making oxygen availability a critical determinant of process performance. Pseudomonas putida, an obligate aerobe and promising host for valorization of aromatic compounds, experiences reduced growth and conversion rates…
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Artikel Jurnal
Exploratory analysis of genotoxic Escherichia coli and Helicobacter pylori virulence in gastrointestinal carcinogenesis
Abstract Gastrointestinal cancers remain among the leading causes of cancer-related mortality worldwide. Beyond environmental and hereditary determinants, increasing evidence suggests that the gut microbiota may contribute to carcinogenesis through persistent infection, expression of virulence…
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Artikel Jurnal
Preparation, characterization and application of feline CD3-specific single-domain antibodies
Abstract Feline lymphoma, a prevalent feline malignancy, responds poorly to conventional chemotherapy—a setting that underscores the urgent need for targeted therapeutic alternatives. The stable expression of CD3 on T-cell lymphoma cells positions this molecule as an ideal immunotherapeutic target…
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Artikel Jurnal
Brucella abortus outer membrane protein modulates host immunity via B-cell receptor-associated protein
Abstract Brucella outer membrane protein 10 (OMP10) plays a critical role in host–pathogen interactions, yet its molecular mechanisms in modulating inflammatory and apoptotic pathways remain unclear. Here, we combined in vivo transcriptional profiling with computational analyses to investigate…
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Artikel Jurnal
Multi-omics analysis reveals the response mechanism of Pichia kudriavzevii to high-concentration lactic acid stress
Abstract Pichia kudriavzevii tolerance mechanisms are not well understood, even though strong-flavor Baijiu fermentation places a heavy burden on yeast metabolism due to the accumulation of lactic acid (LA). This study utilized growth kinetics, electron mi-croscopy, antioxidant tests, and…
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Artikel Jurnal
Gut microbiota metabolites drive osteosarcoma progression through JUP activation: a multi-omics mendelian randomization study
Abstract Osteosarcoma exhibits high heterogeneity and lacks effective therapeutic targets. This study integrated Mendelian randomization, transcriptomics, and 16S rRNA sequencing to investigate potential associations between gut microbiota, metabolites, and osteosarcoma. Multi-omics analysis…
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Moso bamboo invasion into coniferous forests transforms soil microbial communities in subtropical China
Abstract Moso bamboo (Phyllostachys edulis) is an invasive plant species against Japanese cedar (Cryptomeria japonica) plantation forest in subtropical nature reserves, China. However, the effects on soil bacterial and fungal communities caused by Moso bamboo invasion into Japanese cedar forests…
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Artikel Jurnal
Host-associated bioprospecting from Opisina arenosella: a Beauveria bassiana isolate against red palm weevil
Abstract Host-associated bioprospecting of naturally infected insects provides a valuable approach for recovering indigenous entomopathogenic microorganisms adapted to local environments. In this exploratory study, seven microbial isolates (Four fungal and three bacterial) were recovered from…
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Artikel Jurnal
Lactobacillus crispatus attenuates Escherichia coli-induced inflammation and migration of cervical cancer cells
Abstract Comprehensive research has indicated that Lactobacillus, serving as the predominant bacterial genus in the female reproductive tract, effectively restrains pathogenic microorganisms and plays a vital role in upholding urogenital health. In the present study, Lactobacillus crispatus, a…
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Artikel Jurnal
A new diagnostic kit using real-time polymerase chain reaction for the detection of Mycobacterium tuberculosis
Abstract The prevalence of infections by nontuberculous mycobacteria (NTM), which present symptoms similar to tuberculosis (TB), is rising worldwide, highlighting the critical need for precise differential diagnosis. To minimize false-positive TB diagnoses, this study focused on a novel target…
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