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EJNMMI Research
Scopus
ISSN 2191-219X · SpringerOpen · 1,187 articles in the index
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Journal Article
Quantitative assessment of graves’ ophthalmopathy activity using 99mTc-DTPA SPECT/CT orbital imaging: a feasibility study with multiple indicators
Abstract Background Graves' ophthalmopathy (GO) is a challenging autoimmune manifestation of Graves' disease, whose management relies on accurate assessment of inflammatory activity in the extraocular muscles (EOMs). The Clinical Activity Score (CAS), the current gold standard for assessing disease…
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Journal Article
Interreader agreement of intraprostatic prostate cancer detection, local extension and staging using [18F]PSMA-1007 PET and whole-mount radical prostatectomy specimens
Abstract Background To investigate the diagnostic performance and interreader agreement of intraprostatic prostate cancer (PCa) detection, local extension and staging using [18F]PSMA-1007 PET in primary PCa, with whole-mount radical prostatectomy specimens as the reference standard. This…
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Journal Article
Selection of SUV normalization and reference tissue for quantitative [68Ga]Ga-Pentixafor PET/CT analysis
Abstract Background [68Ga]Ga-Pentixafor PET/CT enables visualization of C-X-C chemokine receptor 4 expression, but quantitative accuracy depends on standardized uptake value (SUV) normalization and reference tissue selection. Body composition and variability across candidate organs may confound SUV…
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Journal Article
225Ac-NOTA-trastuzumab human dosimetry using inter-radionuclide and biological half-life based allometric extrapolation method
Abstract Background Image-based dosimetry of 225Ac is challenging due to its high cytotoxicity, which limits the administered dose and, consequently, restricts the number of photons available for imaging. This study aimed to estimate human equivalent dose of 225Ac-NOTA-trastuzumab while considering…
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Journal Article
Repeatability of tumour perfusion measurement with [15O]H2O PET in prostate cancer
Abstract Background Tumour perfusion is a universal cancer biomarker with potential value in characterising primary prostate tumours and longitudinal measurements for evaluation of treatment response. To evaluate whether a change in perfusion is significant, the reproducibility of the measurement…
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Journal Article
Biodistribution, dosimetry, and preliminary imaging of the novel Nectin-4–targeting PET tracer [⁶⁸Ga]Ga-FZ-NR-1 in humans
Abstract Background Nectin-4 is a promising theranostic target for cancers treatment due to its high abundance/expression in different cancer entities such as bladder cancer, breast cancer, and pancreatic cancer This study evaluated the biodistribution and radiation dosimetry of…
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Journal Article
[18F]Fluorocholine PET/CT in a 15-year-old patient suggested HPT-JT syndrome with active cemento-ossifying fibroma
Abstract Background Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is a rare autosomal dominant disorder caused by CDC73 gene mutations, predisposing individuals to primary hyperparathyroidism (pHPT), cemento-ossifying fibromas, and other neoplastic conditions. [18F]Fluorocholine PET/CT has…
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Journal Article
Head-to-head comparison of [177Lu]Lu-FAP-2286 and [161Tb]Tb-FAP-2286 efficacy in a PDAC mouse model
Abstract Background Terbium-161 (Tb-161) emits internal conversion and Auger electrons, in addition to beta-minus radiation, which might be of added benefit for targeted radionuclide therapy (TRT) compared to Lutetium-177 (Lu-177). We extensively compared Lu-177 and Tb-161 for fibroblast activation…
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Journal Article
Beyond discovery: are we understanding PET tracers as fast as we invent them? a critical review
Abstract Background The field of nuclear medicine is experiencing an unprecedented proliferation of novel positron emission tomography (PET) tracers, with FDA-approved PET tracers increasing by 75% between 2020 and 2023 (from 12 to 21 agents). While this innovation promises to advance molecular…
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Journal Article
Optimizing PET/CT protocols: is 60-minute [18 F]F-FDG uptake sufficient for cardiac sarcoidosis?
Abstract Background [18F]F-FDG PET/CT is an established imaging modality for diagnosing cardiac sarcoidosis (CS). While a 90-minute uptake time is commonly recommended to enhance target-to-background ratio, its added diagnostic value remains unclear. This study aimed to compare the diagnostic…
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Journal Article
Angiogenesis PET/MRI predicts initial growth of sporadic vestibular schwannomas: a prospective study with follow-up in 29 patients using [68Ga]Ga-NODAGA-E[c(RGDyK)]2
Abstract Background Vestibular schwannomas (VS) are benign tumors located at the cerebellopontine angle. Although benign, the growth of VS can result in significant morbidity and potential compression of adjacent structures if left untreated. An MRI of the cerebellopontine angle is the…
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Journal Article
Diagnostic value and interpretability of [18F]FDG-PET/CT radiomics in infective endocarditis
Abstract Background to assess the value of [18 F]FDG PET/CT radiomics in infective endocarditis (IE) diagnosis. We evaluated and collected [18 F]FDG PET/CT and clinical data of 447 patients, with suspected IE studied in 3 centers. Radiomic features were calculated and after dimensionality…
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Journal Article
Prediction of tumour hypoxia status from the washout of positron emitters in beam-monitoring PET: carbon-ion irradiation to tumour rat models
Abstract Background The aim of this study was to identify hypoxic regions in tumours using non-invasive imaging without specific radioligands. Tumour hypoxia, which varies during the course of radiation therapy, is an important predictor of treatment effect, therefore, frequent monitoring is…
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Journal Article
Automatic lesion segmentation in ⁶⁸Ga-PSMA PET/CT and ¹⁷⁷Lu-PSMA SPECT/CT: added value of PET-guided SPECT in a bicentric study
Abstract Background Manual segmentation of prostate cancer metastases on PSMA PET/CT and SPECT/CT is time-consuming and poorly scalable, particularly in highly metastatic patients. This study evaluated nnU-Net–based automatic segmentation models trained on PET and SPECT either separately or jointly…
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Journal Article
Long-term outcomes in medullary thyroid cancer patients treated with [177Lu]Lu-DOTAGA.FAPi dimer therapy
Abstract Background Fibroblast activation protein (FAP)-targeted radionuclide therapy is a promising approach for patients with advanced or metastatic medullary thyroid carcinoma (MTC). This study evaluates efficacy, safety, and survival outcomes of [177Lu]/[225Ac]-DOTAGA.Glu.(FAPi)₂ therapy in…
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Journal Article
Identifying genetics biomarkers in correlation with pathological and PSMA PET/CT characteristics in prostate cancer
Abstract Background Prostate cancer is a prevalent disease with diverse tumor characteristics that complicate treatment. The integration of spatial patterns from prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT), pathology and expanding genomic data…
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Journal Article
Correlation of apparent diffusion coefficient, FAP expression in IHC and [68Ga]Ga‑FAPI‑46 uptake using integrated PET/MRI in high-grade soft tissue sarcoma: initial exploratory results
Abstract Background Fibroblast activation protein inhibitor (FAPI)-targeted positron emission tomography (PET) has emerged as a promising imaging approach in soft tissue sarcomas (STS), whereas magnetic resonance imaging (MRI) remains the diagnostic standard. We evaluated integrated…
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