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Natural Products and Bioprospecting
Scopus
ISSN 2192-2195 · SpringerOpen · 469 articles in the index
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Journal Article
Dietary ellagic acid inhibiting gastrointestinal pathogens by modulation of microbiome-metabolite-immune axis
Abstract Antibiotic-induced depletion of the gut microbiota facilitated the colonization of vancomycin-resistant Enterococci (VRE) in the gastrointestinal tract, and then increased patients' susceptibility to secondary infections. Ellagic acid, a major constituent of fruits and nuts, showed various…
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Journal Article
First discovery of triterpenoids and sterols from Cotinus coggygria var. cinereus Engl. with anti-inflammatory and antibacterial activities
Abstract This study led to the isolation of 17 triterpenoids, including two lanostane-type (1 and 2), two dammarane-type (3 and 7), ten tirucallane-type (4 and 8−16), and three oleanane-type (17−19) triterpenoids, as well as nine sterols (5, 6, and 20−26) from Cotinus coggygria var. cinereus Engl…
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Journal Article
Peniexpansones A–F: polyketides from Penicillium expansum DWS880 capable of enhancing the activity of fluconazole against Candida albicans
Abstract Six new polyketides, peniexpansones A–F (1–4, 6, 7), along with an additional novel compound, (2E,4E,6E)-8-methyldeca-2,4,6-trienoic acid (5), and a known naphthopyrone, were isolated from the ethyl acetate extract of rice fermented with the soil fungus Penicillium expansum DWS880…
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Journal Article
De novo synthesis of plant polyketide plumbagin in yeast: a platform for sustainable production of naphthoquinones
Abstract Plumbagin is a natural naphthoquinone with different pharmacological properties and abundantly present in the roots of Plumbago zeylanica L. In spite of its therapeutic anti-cancerous potential, its limited availability from plant sources has slowed down its large scale production. In the…
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Journal Article
Colloidal lignin particles for Pickering emulsion stabilization: multifunctional properties and prospects for cosmetic applications
Abstract Lignin, the most abundant aromatic biopolymer on Earth, is abundantly found as a by-product of biomass processing industries. Lignin presents remarkable properties, including antioxidant, UV-blocking, thermal stability, and antimicrobial; thus being considered a valuable feedstock to…
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Journal Article
Nature meets machine: the AI renaissance in natural product drug discovery
Abstract Natural products (NPs) have long served as a cornerstone of drug discovery, yielding landmark therapeutics such as paclitaxel and artemisinin and providing sustained access to biologically relevant chemical space. Despite this legacy, NP-based discovery has gradually declined with the rise…
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Journal Article
Nematode-trapping fungus Arthrobotrys oligospora is hungry for iron-chelating agent COQ7 of nematodes
Abstract Iron homeostasis is critical for the survival of almost all organisms, yet its dysregulation is often caused by a synergistic effect of genetic and environmental factors. Previous studies have shown that trapping devices of the predominant nematode-trapping fungus (NTF) Arthrobotrys…
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Journal Article
Phenazinoates A‒E, five pairs of phenazine conjugates from a mangrove soil-derived Streptomyces strain OUCMDZ-4923
Abstract Phenazinoates A–E (1–5), comprising five pairs of methyl saphenate conjugates with genistein, o-aminophenol, p-acetaminophenol and glycerol, were isolated from the fermentation broth of mangrove soil-derived Streptomyces sp. OUCMDZ-4923. Their structures were determined through…
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Journal Article
Three naphthomycin type polyketide compounds isolated from strain Streptomyces sp. HKIB0008
Abstract Three new naphthomycin derivatives were isolated and identified from Streptomyces sp. HKIB0008, and were designated as naphthomycin R (1), naphthomycin S (2), and naphthomycin T (3). Their structures were elucidated using a combination of spectroscopic techniques, including high-resolution…
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Journal Article
A critical review on the roles of natural products in shaping oral microbiota and preventing chronic diseases
Abstract The oral microbiome plays a central role in maintaining both oral and systemic health, and disruptions in its balance can contribute to a wide range of diseases. This review brings together current evidence on how natural products modulate oral microbial communities, promote microbial…
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Journal Article
Calabanones A‒H, chromanone derivatives from the stem bark of Calophyllum calaba and their cytotoxic activities against cancer cells
Abstract The genus Calophyllum (Calophyllaceae), distributed mainly in tropical regions, is rich in chromanone derivatives with diverse molecular structures that exhibit potential antimicrobial and anticancer effects. Phytochemical investigation of the stem bark of C. calaba collected in Thailand…
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Journal Article
Targeting Integrin β3: novel antiplatelet lignans 6’-Hydroxyjusticidin B and Neojusticin A from Justicia procumbens unveiled via multi-omics and biophysical validation
Abstract Thrombotic disorders remain a global health burden, necessitating novel antiplatelet agents with improved safety and efficacy. This study investigates the molecular mechanisms of two lignans, 6'-Hydroxyjusticidin B (6'-HJB) and Neojusticin A (Neo-A), isolated from Justicia procumbens L…
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Journal Article
Pyrimidine-containing natural products: occurrences and biological activities
Abstract Nitrogen-containing core structure pyrimidine has long been regarded as one of the privileged scaffolds for novel drug development. Natural products embedded with pyrimidine motifs are distinguished by their exceptional scaffold diversity and vast structural complexity, which endow them…
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Journal Article
Clerodane diterpenoid glycosides from the tuberous roots of Paratinospora sagittata: targeted isolation, structure characterization and immunomodulatory properties
Abstract Guided by the MS/MS-based molecular networking, eight previously undescribed clerodane diterpenoid glycosides, designated tinospinosides F–M (1−8), along with 12 known analogues (9−20), were isolated from the tuberous roots of Paratinospora sagittata. Structural elucidation of the…
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Journal Article
Mining anticoagulant peptides from Poecilobdella manillensis by peptidomics analysis
Abstract Thrombosis triggers various severe diseases, while antithrombotic drugs carry bleeding risks, making the development of novel natural anticoagulants a subject of widespread attention. Poecilobdella manillensis, a prevalent medicinal leech, exhibits remarkable anticoagulant and…
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Journal Article
Polydosetins & pullularins—bioactive tetramic acids & cyclodepsipeptides from the endophytic and nematophagous fungus Polydomus karssenii
Abstract In course of investigating the endophytic and nematode-associated fungus Polydomus karssenii for the production of secondary metabolites, seven previously undescribed natural products were isolated from liquid and solid-state fermentations. 1D and 2D NMR spectroscopy, together with…
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Journal Article
Targeting Hsp70 triggers ferroptosis: a novel anti-cancer mechanism of a marine natural product in prostate cancer
Abstract Prostate cancer (PCa) remains one of the most common malignant tumors among men worldwide, typically relying on the androgen receptor (AR) signaling pathway. Inducing ferroptosis, a novel form of iron-dependent cell death, represents a promising strategy; however, its regulation by AR…
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Journal Article
Three new 14-noreudesmane-type sesquiterpenoids from the roots of Hippophae rhamnoides
Abstract Hippophae rhamnoides L. (Elaeagnaceae), commonly known as sea buckthorn, is a medicinal plant valued for its diverse bioactive constituents and broad therapeutic potential. Phytochemical investigation of its roots led to the isolation of three new 14-noreudesmane-type sesquiterpenoids…
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Journal Article
Revitalizing actinobacteria research: an urgent response to the antimicrobial resistance crisis
Abstract The crisis of antimicrobial resistance (AMR) is escalating while the antibiotic pipeline remains stagnant. Our bibliometric analysis of eight decades of literature reveals a critical imbalance: research on AMR has grown, yet fundamental research on antibiotic discovery has declined. Most…
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Journal Article
Genome mining and functional characterization of four type I sesquiterpene synthases from the Tiger Milk Mushroom Lignosus rhinocerus
Abstract The Tiger Milk mushrooms (Lignosus spp.) have long been used as traditional folk medicines throughout Southeast Asia. However, the chemical constituents of these species remain largely unexplored. In this study, four type I sesquiterpene synthases (LrhTS1−LrhTS4) from Lignosus rhinocerus…