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Neurology and Therapy
Scopus
ISSN 2193-8253 · Adis, Springer Healthcare · 695 artikel di indeks
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Artikel Jurnal
Real-World Comparative Outcomes of Dual vs. Single Antiplatelet Therapy in Acute Ischemic Stroke: A Retrospective Cohort Analysis
Abstract Introduction Short-term use of dual antiplatelet therapy (DAPT) is superior to single antiplatelet therapy (SAPT) for early outcomes in acute ischemic stroke (AIS). However, the long-term effects of SAPT and DAPT remain unclear. This study aimed to evaluate long-term effects of DAPT and…
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Artikel Jurnal
Summary of Research: Pregnancy and Infant Outcomes in Multiple Sclerosis: Findings from the Global MAPLE-MS Pharmacovigilance Program
Abstract Information on pregnancy and infant outcomes after cladribine tablets exposure is limited, as its use is not recommended during pregnancy. This is a summary of the original published article ‘Pregnancy and infant outcomes in multiple sclerosis: findings from the Global MAPLE-MS…
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Artikel Jurnal
Two-Year Outcomes Following Delandistrogene Moxeparvovec Treatment in Ambulatory Patients with Duchenne Muscular Dystrophy: Phase 3 EMBARK Trial
Abstract Introduction Delandistrogene moxeparvovec is a recombinant adeno-associated virus rhesus isolate serotype 74 vector-based gene therapy that addresses the absence of functional dystrophin in Duchenne muscular dystrophy (DMD). EMBARK is a phase 3, two-part, crossover, randomized…
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Artikel Jurnal
Anti-aging and Anti-inflammatory Dietary Interventions in Multiple Sclerosis: A Narrative Review
Abstract Multiple sclerosis (MS) is a chronic sex-biased (3♀:1♂) immune-mediated demyelinating disease of the central nervous system (CNS). Disease-modifying therapies targeting the peripheral immune cells efficiently limit relapses in early MS but cannot abrogate the chronic progressive component…
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Artikel Jurnal
Venous Blood Cell Ratios as Predictors of Reperfusion Outcomes in Ischemic Stroke: A Systematic Review and Meta-analysis
Abstract Introduction Inflammation plays a critical role in the pathophysiology of acute ischemic stroke (AIS). Ratios derived from routine blood counts, especially the neutrophil-to-lymphocyte ratio (NLR), have been proposed as prognostic biomarkers, but their value in patients receiving…
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Artikel Jurnal
Patient Experiences with Relapsing–Remitting and Primary Progressive Multiple Sclerosis: Development of a Conceptual Model to Inform Clinical Outcome Assessment Evaluation
Abstract Introduction Multiple sclerosis (MS) is an autoimmune-mediated neurodegenerative disorder. The United States Food and Drug Administration recommends using clinical outcome assessments (COAs) to measure concepts that matter to patients in clinical trials and to document the content validity…
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Artikel Jurnal
From Stroke to Strength: The Role of Exercise in Managing Hypertension and Lipid Profiles
Abstract Secondary stroke prevention focuses on managing vascular risk factors such as hypertension, hyperglycemia, and dyslipidemia. However, the impact of exercise training regimens (ETR) on these factors post-stroke remains unclear. We conducted a network meta-analysis (NMA) to compare the…
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Artikel Jurnal
Clinical and Humanistic Burden Among Adults with Neurofibromatosis Type 1 and Symptomatic Plexiform Neurofibroma in the United States
Abstract Introduction Neurofibromatosis type 1 with plexiform neurofibromas (NF1-PN) can cause substantial clinical morbidity, yet the overall humanistic burden in adults remains poorly characterized. This study assessed health-related quality of life (HRQoL), in addition to clinical…
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Artikel Jurnal
Time and Motion Study to Quantify Time for Tysabri (Natalizumab) Intravenous Versus Subcutaneous to Treat Relapsing-Remitting Multiple Sclerosis in France, Spain, and the United Kingdom
Abstract Introduction Tysabri (natalizumab) is a recombinant humanized IgG4 monoclonal antibody for the treatment of adults with highly active relapsing-remitting multiple sclerosis (RRMS). A subcutaneous (SC) formulation administered by healthcare professionals (HCPs) is expected to save time for…
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Artikel Jurnal
Reducing Early-Life Smoke Exposure as a Preventive Strategy for Pediatric Multiple Sclerosis: Results from the PEDIGREE Study
Abstract Introduction Assessing the environmental impact on multiple sclerosis (MS) is complex because of long disease latency and potential recall bias, especially for perinatal exposures. This study aimed to investigate the association between parental smoking and the development of pediatric MS…
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Artikel Jurnal
Long-Term Impact of Cenobamate on Cognition, Adaptive Behavior, and Quality of Life in Patients with Tuberous Sclerosis Complex
Abstract Introduction Cenobamate is a recent therapeutic option for epilepsy, but few studies have investigated its impact on cognitive and emotional/behavioral functioning. The aim of our study was to assess cognitive function, adaptive behavior, quality of life, and parental stress in late…
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Artikel Jurnal
Efgartigimod as an Add-on Therapy for Anti-IgLON5 Disease: A Case Report
Abstract Anti-IgLON5 disease is a rare neuronal surface antibody-associated encephalopathy characterized by complex and diverse clinical manifestations, including sleep disturbances, bulbar symptoms, abnormal movements, cognitive decline, and occasionally, neuropsychiatric abnormalities…
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Artikel Jurnal
Thrombolysis with Adjunctive Tirofiban in Acute Non-cardioembolic Posterior Circulation Ischemic Stroke: A Propensity Score-Matched Analysis
Abstract Introduction This study aimed to compare clinical outcomes between recombinant tissue plasminogen activator plus tirofiban (rt-PA + T) and rt-PA alone in patients with acute non-cardioembolic posterior circulation ischemic stroke (APCIS) treated within 24 h. Methods In this retrospective…
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Artikel Jurnal
Sustained Efficacy of Eptinezumab in Participants with Migraine for Whom Prior Preventive Treatments Failed and Who Self-reported Psychiatric Comorbidities: Post Hoc Analysis of the Placebo-controlled DELIVER Trial
Abstract Introduction Psychiatric comorbidities increase the risk of migraine disease progression. These post hoc analyses explored whether self-reported psychiatric comorbidities at screening had an impact on the short- and long-term efficacy of eptinezumab in the DELIVER trial. Methods DELIVER…
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Artikel Jurnal
Dementia in Progressive Supranuclear Palsy: A Narrative Review
Abstract Progressive supranuclear palsy (PSP) is an adult-onset neurodegenerative disorder characterized by postural instability, ocular motor dysfunction, akinesia, and cognitive impairment. The accumulation of tau protein disrupts microtubule dynamics and axonal transport, leading to…
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Artikel Jurnal
Incorporating Patient Perspectives into a Composite Score for Measuring Disease Progression in Spinocerebellar Ataxia (SCA)
Abstract Introduction The spinocerebellar ataxia composite score (SCACOMS) comprises items from the functional Scale for the Assessment and Rating of Ataxia (f-SARA) and the Clinician Global Impression of Change (CGI-C). In the derivation of SCACOMS, weights reflecting 1-year responsiveness were…
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Artikel Jurnal
Temporal Dynamics of Cerebral Autoregulation after Aneurysmal Subarachnoid Hemorrhage: Insights from Pressure Reactivity Index and Non-injured Controls
Abstract Introduction Aneurysmal subarachnoid hemorrhage (aSAH) disrupts cerebral autoregulation, contributing to secondary brain injury and poor outcomes. The low-frequency pressure reactivity index (LPRx) is an indirect index of autoregulatory function derived from invasive intracranial pressure…
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Artikel Jurnal
The Patient Experience of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Post-Diagnosis: Results from an International Survey
Abstract Introduction Data on the post-diagnosis experience of individuals with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and their caregivers are limited. We explored post-diagnosis treatment experience and satisfaction with care in individuals with MOGAD and…
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Artikel Jurnal
Assessment of Transition Plan Implementation and Provider Engagement Among Adults Living with Spinal Muscular Atrophy (SMA): Findings from a Cross-Sectional Survey
Abstract Introduction Advances in disease-modifying therapies have improved outcomes and survival in spinal muscular atrophy (SMA), resulting in a growing population of adolescents and young adults who must transition from pediatric to adult healthcare systems. Despite longstanding professional…
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Artikel Jurnal
Real-World Response and Super-Response to Eptinezumab over 48 Weeks in Migraine: The Prospective Multicenter EMBRACE III Study
Abstract Introduction Long-term (> 24 weeks) real-world evidence of eptinezumab’s effectiveness is limited. We evaluated ≥ 50% and ≥ 75% response rates over 48 weeks in patients with high-frequency episodic migraine (HFEM) or chronic migraine (CM). Methods EMBRACEIII (NCT05570149) is a prospective…