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Intensive Care Medicine Experimental
Scopus
ISSN 2197-425X · SpringerOpen · 826 artikel di indeks
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Artikel Jurnal
Bedside detection of end-tidal overdistention: an exploratory comparison of loading maneuvers
Abstract Background Paradoxical improvement in respiratory system compliance with chest wall loading (‘mechanical paradox’) has been well described in adult respiratory distress syndrome (ARDS), especially in the setting of severe Covid-19 pneumonia. A standardized bedside technique of chest wall…
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Artikel Jurnal
Machine learning-driven prediction model for successful weaning of patients from mechanical ventilation in ICU
Abstract Background Mechanical ventilation is a critical life support technology in the intensive care unit. However, the weaning process remains complex, making the optimal timing for liberation from ventilation challenging to ascertain and imposing a considerable clinical workload. Additionally…
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Artikel Jurnal
Effect of lateral positioning on ventilation in patients with blunt thoracic injury during pressure support ventilation: the VICTORY study
Abstract Background In patients with blunt thoracic injury requiring mechanical ventilation lateral positioning is routinely performed. Whether it modifies ventilation distribution and aeration is unclear. Study design and methods Patients receiving pressure support ventilation (PSV) were…
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Artikel Jurnal
Perioperative micro-arterial function and extravasation in cytoreductive ovarian cancer surgery: an observational study
Abstract Background Patients undergoing extended multivisceral, non-cardiac surgery require a high demand for intravenous fluid administration, leading to substantial positive fluid balances. This study aimed to perioperatively characterize extravasation as a correlate of capillary leakage and…
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Artikel Jurnal
Clinical practice in using corticosteroids and adjunctive sepsis therapies at the bedside among European ICUs: an ESICM-endorsed survey
Abstract Background Sepsis and septic shock remain major causes of morbidity and mortality worldwide, and management is largely based on source control, antimicrobial therapy, and supportive care. Despite limited high-quality evidence, adjunctive therapies targeting the dysregulated host response…
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Artikel Jurnal
Endotoxemia and its association with immune and coagulopathy responses in severe community-acquired pneumonia and COVID-19
Abstract Background Acute community-acquired pneumonia (CAP) is a leading cause of infection-related mortality worldwide. Endotoxemia, characterized by elevated plasma lipopolysaccharide (LPS), is a key driver of inflammation and thrombosis in Gram-negative sepsis and has been suggested to occur in…
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Artikel Jurnal
Admission systemic immune-inflammatory index predicts long-term mortality in patients with acute ischemic stroke: a retrospective analysis of the MIMIC-III database
Abstract Background The Aggregate Index of Systemic Inflammation (AISI) is a novel index based on platelets, neutrophils, and lymphocytes associated with the prognosis of patients with cancer and infectious diseases. However, its application in acute ischemic stroke (AIS) has rarely been reported…
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Artikel Jurnal
The impact of metabolic syndrome on regional ventilation and perfusion in ARDS: an observational cohort study using electrical impedance tomography
Abstract Background Acute Respiratory Distress Syndrome (ARDS) is characterized by severe hypoxemia from heterogeneous impairments in regional ventilation and perfusion. Metabolic syndrome, a combination of central obesity, insulin resistance, hypertension, and dyslipidemia, affects over one-third…
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Artikel Jurnal
Milrinone and levosimendan improve microvascular perfusion in septic rats: a randomized, placebo-controlled trial
Abstract Background Microcirculatory dysfunction is a key pathophysiological feature of sepsis and contributes to organ failure and mortality. In the gastrointestinal tract, impaired barrier function due to microcirculatory injury promotes translocation of inflammatory mediators and bacteria…
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Artikel Jurnal
Ventilation–perfusion effects of negative-pressure ventilation: insights from an experimental rat model
Abstract Background Mechanical ventilation typically utilizes positive-pressure ventilation (PPV), which fundamentally differs from physiological pressure conditions. In contrast, negative-pressure ventilation (NPV) more closely mimics physiological pressure conditions; however, its impact on…
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Artikel Jurnal
Oxidized albumin and its association with mortality in critically ill Covid-19 patients: a retrospective cohort study
Abstract Background Albumin is the most abundant protein in the human circulation and has many important functions. Recent studies have shown that albumin is a free radical scavenger and can be oxidized to single (HNA-1) or double (HNA-2) oxidized albumin. Oxidized albumin is a predictor for…
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Artikel Jurnal
ARIMA-based forecasting of cerebral physiologic signals in acute traumatic brain injury: a CAnadian high-resolution TBI (CAHR–TBI) cohort study
Abstract Background Traumatic brain injury (TBI) remains a major global health issue, with limited progress in reducing morbidity and mortality for TBI patients in need of sedation and intensive care. This has led to increased focus on the mechanisms of secondary brain injury, typically monitored…
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Artikel Jurnal
Animal models of critical illness in the Asia–Pacific region: current practices, shared challenges, and future directions
Abstract Animal models of critical illness span diverse species and experimental approaches, reflecting the biological complexity of severe disease states while being constrained by animal welfare requirements and country-specific regulatory, infrastructural, and workforce factors. Persistent…
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Simple and reliable method for predicting extracorporeal membrane oxygenation flow rates and circuit pressures
Abstract Background Venovenous extracorporeal membrane oxygenation (ECMO) is essential for patients with severe respiratory failure who do not respond to conventional mechanical ventilation. Adequate ECMO flow and safe circuit pressure are critical; however, cannula selection, which has a great…
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Artikel Jurnal
The P0.1 maneuver as an alternative method for assessing the validity of esophageal pressure measurements during assisted ventilation: an exploratory analysis
Abstract Background Transpulmonary pressure, calculated as the difference between airway pressure (Paw) and esophageal pressure (Pes), is an important monitoring parameter during assisted mechanical ventilation, provided Pes is measured via a correctly placed and filled esophageal pressure probe…
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Artikel Jurnal
Microbial lung-to-blood translocation associates with systemic inflammation in severe pneumonia: evidence from paired plasma and lower respiratory tract metagenomics
Abstract Background Biological heterogeneity in host inflammatory responses to severe pneumonia predicts clinical outcomes and may influence the effectiveness of immunomodulatory therapy. The upstream drivers of this heterogeneity remain poorly defined. We hypothesized that microbial translocation…
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Artikel Jurnal
Immune dysregulation through longitudinal lymphocyte trajectories and their clinical determinants in hospitalized COVID-19 patients
Abstract Objective Immune dysregulation plays a pivotal role in the pathophysiology of sepsis and COVID-19, with lymphopenia emerging as a consistent marker of severity and poor prognosis. However, most existing studies have assessed lymphocyte counts at isolated time points, limiting insights into…
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Artikel Jurnal
Pre-existing systemic inflammation impairs bacterial clearance in the spleen
Abstract Background Sepsis-induced immunosuppression impairs bacterial clearance and increases mortality. Liver and spleen macrophages are an essential part of the mononuclear phagocyte system and crucial for bacterial elimination. Systemic inflammation hampers bacterial clearance in the liver. We…