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Advanced Science
Scopus
ISSN 2198-3844 · Wiley · 16.887 artikel di indeks
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Artikel Jurnal
MSC Membrane‐Coated circPROSC‐siRNA Nanoparticles for Ameliorating Craniosynostosis by Inhibiting Premature Suture Ossification
Abstract Craniosynostosis is a congenital craniofacial disorder caused by excessive osteogenic differentiation of mesenchymal stem cells (MSCs) within cranial sutures. Due to incompletely understood regulatory mechanisms, effective solutions for early diagnosis and minimally invasive therapy remain…
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Artikel Jurnal
Mechanical Environment Afforded by Engineered Hydrogel Critically Regulates Survival of Neural Stem Cells Transplanted in the Injured Spinal Cord via Piezo1‐Mediated Mechanotransduction
Abstract Neural stem cell (NSC) transplantation is a promising therapeutic approach for spinal cord repair, but poor graft survival remains a critical challenge. This work reports that the mechanical properties of the transplantation environment play a crucial role in NSC survival in the injured…
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Artikel Jurnal
Tie2‐Dependent Mechanisms Influence Leptomeningeal Collateral Dynamics and Reperfusion Following Stroke
Abstract Leptomeningeal collateral vessels help redistribute cerebral blood flow following arterial obstruction, reducing tissue damage. This study investigates the Tie2 receptor peptide agonist Vasculotide in a permanent middle cerebral artery occlusion (pMCAO) model. Vasculotide enhanced early…
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Artikel Jurnal
Catalytic Electron‐Driven Non‐Equilibrium Phase Transition in Quantum Electronic Heterostructures
Abstract Thermodynamic phases of matter are defined by temperature, pressure, and particle number while their changes in solids are known to induce phase transitions. It is demonstrated that in heterostructures with an extra degree of freedom—two different electron pathways across the…
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Artikel Jurnal
Manipulating the Spin State of Perovskite Cs3Bi2Br9 by Co‐Doped for Efficient Photocatalytic CO2 Reduction
Abstract The photocatalytic conversion of CO2 into the renewable fuels is a promising strategy to address energy and environmental challenges, however, its limited application is mainly attributed to the inefficient charge separation and lack of active sites in conventional catalysts. Here, a…
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Artikel Jurnal
FXYD3 Promotes Tumor Progression by Binding With IRF7 to Regulate JAK2/STAT5 Signaling in Intrahepatic Cholangiocarcinoma
Abstract Intrahepatic cholangiocarcinoma (ICC) has a poor prognosis, especially for inoperable patients. FXYD3, an FXYD‐domain‐containing regulator in the Na+/K+ ATPase family, is overexpressed in several common cancers. However, its role in ICC progression remains unclear. We integrated multiple…
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Artikel Jurnal
Long‐Term Memory Updating Parallels Altered Awake and Sleep Hippocampal Replays
Abstract The activity of hippocampal place cells is essential for various processes of spatial memory, including encoding, consolidation, and retrieval. However, whether they also participate in spatial memory updating remains elusive. This study demonstrates that during the process of long‐term…
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Artikel Jurnal
Replacing Helper Lipids With Cationic Lipids Enhances mRNA Lipid Nanoparticles Stability in Solution
Abstract Messenger RNA lipid nanoparticles (mRNA‐LNPs) have achieved remarkable success in clinical vaccination efforts to curb the COVID‐19 pandemic, and have attracted tremendous interest from both industry and academia to broaden their biomedical applications. However, their storage and…
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Subventricular Zone‐on‐a‐Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage
Abstract Intraventricular hemorrhage (IVH) in preterm infants disrupts neurogenesis in the subventricular zone (SVZ), a key neurogenic niche, yet no effective treatments exist. This work develops a human SVZ‐on‐a‐chip model to investigate the inflammatory response in IVH and its impact on…
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Artikel Jurnal
Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles
Abstract Glioblastomas (GB) are the most common and deadly primary malignant brain tumors due to their infiltrative growth and resistance to conventional therapies. GB cell plasticity and differentiation into drug‐resistant mesenchymal‐like (MES) states protect tumors from conventional treatments…
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Artikel Jurnal
An Efficient CO2‐Upcycling Platform Based on Engineered Halomonas TD with Enhanced Acetate‐Utilizing Capacity via Adaptive Laboratory Evolution
Abstract Biohybrid conversion of carbon dioxide (CO2) into value‐added bioproducts via engineered microbes using CO2‐derived electrolytes (CDE) addresses global CO2 emissions, but most recombinants have poor saline CDE tolerance and low carbon conversion rate (CCR). Herein, Halomonas TD…
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Artikel Jurnal
Modulating a Massive Set of Biomolecular Structures by Sono‐Mechanical Force
Abstract Mechanical modulation of biomolecular structures by single‐molecule techniques, such as optical tweezers, has revealed subtle conformational dynamics and enabled precise modulation of functional properties. However, such tools are limited to manipulating one or a few molecules at a time in…
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Artikel Jurnal
Cancer Manipulates Adjacent Adipose Tissue to Exploit Fatty Acids via HIF‐1α/CCL2/PPARα Axis: A Metabolic Circuit to Support Tumor Progression
Abstract Rising obesity rates are closely linked to higher risk of cancer, yet the underlying mechanisms are not fully understood. It is previously reported that fatty acids (FAs) released from cancer‐associated adipose tissue enhance hypoxia‐inducible factor‐1α (HIF‐1α) expression in cancer cells…
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Artikel Jurnal
Co‐Self‐Assembled Interface Engineering Assisted for Bend‐Resistant and Efficient Flexible Perovskite Solar Cells
Abstract Flexible perovskite solar cells (F‐PSCs) have attracted considerable interest for their superior mechanical flexibility. Nonetheless, cryptic bottom‐interface defects hinder further improvements in device performance. Here, a co‐self‐assembled monolayer (Co‐SAM) engineering strategy is…
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Artikel Jurnal
Free‐Standing Halogen‐Bonded Nanosheets Formed by Ultrasonic Liquid Exfoliation
Abstract Strong in‐layer interactions are typically considered a key requirement for exfoliating layered materials to form nanosheets. Here, the formation of free‐standing nanosheets held together by halogen bonding interactions is reported for the first time. Layered co‐crystals are synthesized…
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Artikel Jurnal
A Two‐Stage Cascading Amplification Strategy Based on Zn2+‐Doped WOX Nanozymes for Ultrasensitive Lateral Flow Immunoassays of Clostridium Difficile Toxin B
Abstract Clostridium difficile is one of the primary causative agents of nosocomial antibiotic‐associated diseases. Early detection and prevention are effective strategies to curb disease transmission, which often requires highly sensitive point‐of‐care testing (POCT) methods. Although lateral flow…
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Artikel Jurnal
An Active, Multimodal Neural Interface for Real‐Time Monitoring of Cortical Electrical, Thermal, and Optical Dynamics
Abstract Chronic neurophysiological monitoring devices facilitate the timely diagnosis and treatment of episodic or recurrent neurological disorders. Compared with passive electrodes, silicon‐based active transistors provide intrinsic signal amplification and, when combined with capacitive‐coupling…
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Artikel Jurnal
KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression
Abstract Cholangiocarcinoma (CCA) is a liver cancer subtype with poor survival rates. KRAS mutations are found in 15–40% of CCA, representing a new potential treatment target. Whether KRAS inhibition leads to CCA tumor regression is unknown, partly due to the lack of conditional animal models. A…
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Artikel Jurnal
Acceptor‐Bridged Engineering Enables Highly Efficient Solution‐Processed Pure‐Green MR‐TADF OLEDs With External Quantum Efficiency of 29% and Small Roll‐Off
Abstract The pursuit of next‐generation ultrahigh‐definition displays has intensified the demand for narrowband emitters with exceptional color purity and high efficiency. Despite the demonstrated superiority of multi‐resonance thermally activated delayed fluorescence (MR‐TADF) emitters in…
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Artikel Jurnal
Grain Boundary Segregation Suppresses Local Short‐Range Ordering in Nanocrystalline High‐Entropy Alloys
Abstract Multi‐principal‐element alloys like high‐entropy alloys (HEAs) have potential applications in many engineering fields due to their unique mechanical/functional properties. While HEAs are generally considered random solid solutions, recent studies revealed that they are prone to…
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