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International Journal for Parasitology: Drugs and Drug Resistance
Scopus
ISSN 2211-3207 · Elsevier · 562 artikel di indeks
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Artikel Jurnal
Benzimidazole resistance in Haemonchus contortus in small ruminants: molecular mechanisms and diagnostic approaches
Benzimidazole resistance in Haemonchus contortus represents a widespread challenge in small ruminant production worldwide. Benzimidazoles remain one of the most commonly used drug classes, due to their broad spectrum of activity, affordability, and ease of administration. However, extensive and…
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Artikel Jurnal
Halogenation of neolignan scaffolds reveals stage-specific anthelmintic activity against Haemonchus contortus
Gastrointestinal nematodes, including Haemonchus contortus, represent a major constraint to livestock production globally, and the increasing prevalence of anthelmintic resistance necessitates the discovery of new chemotypes. Natural products provide a rich and underexplored source of bioactive…
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Artikel Jurnal
Histone deacetylase inhibitors enhance the amoebicidal activity of amphotericin B against Naegleria fowleri
Naegleria fowleri is a free-living amoeba that causes a rare but almost always fatal brain infection known as primary amoebic meningoencephalitis (PAM). Although amphotericin B (AmB) is considered the primary treatment for PAM, it is often recommended in combination with several other drugs due to…
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Artikel Jurnal
High-throughput phenotypic screening of Medicines for Malaria Venture's Hit Generation Library 1 identifies new nematocidal chemotypes
Parasitic helminths impose substantial health and economic burdens on humans and livestock, and widespread resistance to existing anthelmintic classes underscores the urgent need for new chemotypes with distinct mechanisms of action as part of integrated parasite control strategies. Here, we…
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Artikel Jurnal
Pharmacokinetics of fenbendazole and its bioactive metabolite oxfendazole in northern bobwhite administered an anthelmintic feed
The northern bobwhite (Colinus virginianus) has experienced significant population declines across its native range. Parasitic nematodes are increasingly being recognized as contributing factors. QuailGuard®, an anthelmintic feed that uses fenbendazole (FBZ) as the active ingredient, has shown…
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Artikel Jurnal
TRPtracker: a community database for monitoring praziquantel sensitivity at TRPMPZQ variants
The anthelmintic praziquantel (PZQ) has been used for decades as the clinical therapy for schistosomiasis, and remains the only available drug. As a cheap and effective drug therapy for all human disease-causing Schistosoma species, usage of PZQ underpins mass drug administration strategies aimed…
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Artikel Jurnal
P-glycoproteins and amphids: a two-stage trajectory of ivermectin resistance in Caenorhabditis elegans
Ivermectin (IVM) is a cornerstone of nematode control. However, its efficacy is increasingly compromised by emerging resistance in target parasites. P-glycoproteins (Pgps), which mediate drug efflux, and amphid neuron defects, characterized by a dye-filling defective (Dyf) phenotype, may both…
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Artikel Jurnal
A practical miracidial motility assay for assessing Fasciola hepatica sensitivity to compounds in vitro
Fasciola hepatica causes fasciolosis in livestock and humans worldwide, yet reliable tools to assess drug efficacy against the early developmental stages of this parasite are lacking. Here, we developed an automated miracidial motility assay (MMA) using the WMicroTracker ONE infrared detection…
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Artikel Jurnal
Efficacy of phosphonium amphiphilic salts against Acanthamoeba genotype T4
Acanthamoebae are opportunistic pathogens causing serious human infections, including granulomatous amoebic encephalitis (GAE) and Acanthamoeba keratitis (AK). The treatment of those infections is limited and difficult to date. Recent research demonstrated high antimicrobial activity of phosphonium…
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Artikel Jurnal
Meclonazepam sensitivity of parasitic flatworms correlates with TRPMMCLZ sensitivity to meclonazepam
The ionotropic portfolio of parasitic flatworms affords considerable opportunity for development of new anthelmintics. In this regard, transient receptor potential ion channels (TRP channels), cation channels responsive to various physiochemical cues, have emerged as promising druggable targets…
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Artikel Jurnal
Ferrostatin-1 alleviates experimental cerebral malaria by regulating immune cell functions and brain endothelial ferroptosis
Cerebral malaria (CM), a life-threatening complication of Plasmodium falciparum infection, is characterized by dysregulated immune responses and blood-brain barrier (BBB) damage. In this study, we found that iron metabolic disorders occurred in the spleen and brain tissues in response to Plasmodium…
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Artikel Jurnal
Anti-cryptosporidial efficacy of tricyclic carbazole aminoalcohols in vitro and in vivo
Cryptosporidiosis is a major cause of diarrheal disease in humans and animals, yet there are no fully effective drugs, particularly for immunocompromised patients. Carbazole aminoalcohols (CAAs) are a relatively unexplored chemical class with reported broad-spectrum antiparasitic activities. Here…
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Artikel Jurnal
Development and evaluation of quadruplex droplet digital PCR assay for rapid detection of molecular markers associated with macrocyclic lactone resistance and susceptibility in Dirofilaria immitis
Due to climate change and human interventions, there has been an increase in D. immitis infections, underscoring the necessity for monitoring the spread and extent of resistance. In our prior research, we introduced a rapid test utilizing four predominant SNP markers at loci 15709 (SNP1), 30575…
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Artikel Jurnal
The EamA metabolite transporter does not affect antileishmanial drug susceptibility
Leishmaniasis is a major neglected tropical disease, exists in 98 countries and constitutes a global public health threat. As chemotherapy is confronted with drug resistance and treatment failure, understanding the underlying mechanisms and continued drug discovery efforts are needed in the fight…
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Artikel Jurnal
Prevalence of antimalarial drug resistance molecular markers in Makenene, central Cameroon
Background: Antimalarial drug resistance remains a significant challenge in the fight against malaria in Cameroon. Given the high prevalence of malaria in Makenene in central Cameroon and the limited knowledge of drug resistance profiles in the area, the prevalence of Plasmodium falciparum drug…
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Artikel Jurnal
In vitro and in vivo anti-piroplasm activity of PBT2 against Theileria annulata and Babesia microti
Theileriosis and babesiosis remain major constraints to livestock production, and increasing drug resistance necessitates alternative therapeutic strategies. Here, we evaluated the metal ionophore PBT2 for anti-piroplasm activity. PBT2 inhibited proliferation of two Theileria annulata schizont…
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Artikel Jurnal
Pharmacology and toxicology of veterinary isoxazolines: a review
Isoxazoline derivatives have rapidly become cornerstone ectoparasiticides in veterinary medicine, providing high efficacy and long-lasting protection against fleas, ticks, and other arthropods in companion animals and, more recently, in food-producing species. This review summarizes current…
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Artikel Jurnal
Challenges in applying W.A.A.V.P. criteria to diagnosing triclabendazole resistance in Fasciola hepatica, an example from the Southern Tablelands of New South Wales, Australia
Fasciola hepatica (liver fluke) is a zoonotic parasite of global concern. In Australia, it is the 13th most important cause of economic loss in the sheep meat industry alone. Resistance to the frontline drug, triclabendazole (TCBZ), was first recorded in Australia in 1995 and has since emerged…
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Artikel Jurnal
Ribosomal protein L27 contributes to virulence and maduramicin resistance in Eimeria tenella
Coccidiosis, which is primarily caused by Eimeria spp., poses a persistent challenge to poultry health and production worldwide. The emergence and spread of drug-resistant strains have significantly compromised the efficacy of anticoccidial therapies. We previously used RNA-seq to demonstrate that…
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Artikel Jurnal
Trialling the SmartWorm® application in New Zealand sheep farms
Gastrointestinal nematodes (GIN) remain a major health and productivity challenge for grazing livestock globally, including New Zealand where widespread anthelmintic resistance has been reported. This was a pilot study evaluating the effectiveness of SmartWorm®, an app-based decision-support tool…