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Acta Pharmaceutica Sinica B
Scopus
ISSN 2211-3835 · Elsevier · 2.948 artikel di indeks
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Artikel Jurnal
Elesclomol-mediated cuproptosis overcomes cisplatin resistance by restricting epigenetically activated mitochondrial respiration: Novel therapeutic insights into cisplatin–elesclomol combination therapy
Chemoresistance remains a significant challenge in cancer treatment, substantially limiting therapeutic efficacy. Cuproptosis is copper-induced cell death driven by mitochondrial protein aggregation and metabolic dysfunction. However, the involvement of cuproptosis in chemoresistance remains…
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Artikel Jurnal
Neuroprotection by YZG-331 in postoperative cognitive dysfunction via Mg2+-dependent blockade of NMDA receptors
Postoperative cognitive dysfunction (POCD) is a debilitating neurological complication that occurs following surgery, for which no effective interventions are currently available. Here, we identified YZG-331, a novel adenosine analog, as a promising neuroprotective agent that rescues cognitive…
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Red light-responsive bioorthogonal chemistry enabled on-demand prodrug activation for cancer therapy
Light-driven chemistry has revolutionized modern medicine, enabling precise disease detection and on-demand therapeutic interventions with high spatiotemporal accuracy. However, despite tremendous advances in bioorthogonal reactions, photoclick chemistry-based therapeutics remain as a challenge in…
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The polymeric nanovectors landscape for cancer immunotherapies towards advanced therapy medicinal products (ATMPs)
Despite major advances in oncology, cancer remains one of the leading causes of mortality worldwide, underscoring the need for more effective and personalized therapeutic solutions. Advanced therapy medicinal products (ATMPs), including gene and cell-based therapies, have emerged as a promising…
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Artikel Jurnal
SIRT6 activator MDL-800 alleviates periodontal inflammation by inhibiting AIM2 pathway
Periodontitis is an infectious and inflammatory disease. The inability to control clinical inflammation significantly contributes to unsuccessful periodontal treatment. As a key regulator of epigenetics, Sirtuin 6 is one of the NAD+-dependent histone deacetylase family members and has recently…
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Artikel Jurnal
Photothermal-driven sequential immunotherapy overcomes resistance to PARP inhibition in Brca1-deficient triple-negative breast cancer
Triple-negative breast cancer (TNBC) faces formidable clinical challenges due to target scarcity and a profound immunosuppressive microenvironment, necessitating innovative therapeutic strategies. Although poly ADP-ribose polymerase inhibitors leverage synthetic lethality in BRCA-mutated tumors…
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Targeting the SETD2–FTO–KIT pathway as a pharmacological strategy for TKI-refractory GIST
Tyrosine kinase inhibitors (TKIs) have significantly improved outcomes in gastrointestinal stromal tumors (GIST), but acquired resistance remains a major clinical obstacle. The underlying mechanisms that sustain oncogenic KIT signaling in TKI-refractory GIST are not fully understood. Here, we…
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Artikel Jurnal
L-cell-specific Abca1 deficiency impairs glucose homeostasis through defective GLP-1 production in mice
Evidence suggests dietary cholesterol intake associates with higher diabetes risk, but mechanisms need further study. Glucagon-like peptide-1 (GLP-1), a glucose-regulating hormone produced by intestinal L-cells, has served as the basis for widely used diabetes therapeutics. However, how dietary…
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Deconvoluting the multi-faceted roles of alternative splicing events in cancer: From underlying mechanisms to innovative therapeutics
Alternative splicing (AS) is well-known to be a critical mechanism to enhance proteomic diversity from a limited genome. Dysregulation of AS may represent a key tumor-specific molecular feature; thereby driving tumorigenesis and progression. Elucidating the mechanisms underlying AS dysregulation in…
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CMTM6 maintains B cell-intrinsic membrane CD40 stability to regulate anti-tumor immunity
The essential role of B cells and B cell intrinsic molecules in tumor immunity is beginning to be recognized. Tumor cell CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) is a novel tumor immunoregulator involved in maintaining membrane levels of several important molecules, such…
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Artikel Jurnal
Neutrophil-mediated BDNF delivery for the treatment of moderate to severe Alzheimer’s disease
Alzheimer’s disease (AD), especially its moderate-to-severe stage (MSAD), remains a global health challenge with no disease-modifying therapies. Here, we identified a dual pathological signature in MSAD patients and murine models: a systemic pro-inflammatory milieu and critically reduced…
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Molecular architecture responsible for specific inhibition of oncogenic PI3Kα mutants by RLY-2608 and STX-478
Hotspot mutations in phosphoinositide 3-kinase alpha (PI3Kα), such as H1047R, E542K, and E545K, drive tumorigenesis across multiple cancer types. Orthosteric PI3Kα inhibitors are effective but have toxicity against wild-type PI3Kα, the emergence of resistance, and a narrow therapeutic index…
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Artikel Jurnal
Targeting the nervous system: Mechanistic insights into neuro–tumor communication and therapeutic opportunities
The nervous system has emerged as an active regulator of the tumor ecosystem. Neural inputs from the central, peripheral, and enteric nervous systems influence tumor initiation, progression, metastasis, and therapeutic response through innervation and signal transmission. In addition to regulating…
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Artikel Jurnal
Lipid nanoparticles as active biointerfaces: From membrane interaction to systemic dysregulation
Lipid nanoparticles (LNPs) are central to modern mRNA therapeutics, including COVID-19 vaccines. Far from passive carriers, their ionizable lipids actively interact with cellular membranes. Evidence from cellular, transcriptomic, and proteomic studies indicates that LNPs, with or without nucleic…
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