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FEBS Open Bio
Scopus
ISSN 2211-5463 · Wiley · 1.801 artikel di indeks
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Artikel Jurnal
Protein O‐glycosylation in the Bacteroidota phylum
Glycans play crucial roles in bacteria, such as providing structural integrity or enabling interactions with the ecosystem. They can be linked to lipids, peptides, or proteins. In proteins, they modify either asparagine (N‐glycosylation) or serine or threonine (O‐glycosylation). Species of the…
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Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer
Cancer‐associated fibroblasts (CAFs) contribute to immunosuppression in the ovarian cancer microenvironment, partly through upregulation of indoleamine 2,3‐dioxygenase 1 (IDO1). This study examined CAF‐mediated suppression of T‐cell function and the potential of IDO1 inhibition to reverse these…
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Highlights of the FEBS3+ meeting Exploring molecular frontiers
FEBS+ meeting Exploring molecular frontiers, held in Pula, Croatia, in autumn 2024 was jointly organized by the Croatian, Finnish, and Swedish Member Societies of the Federation of European Biochemical Societies (FEBS). The congress covered a wide variety of different biochemical themes, some of…
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Molecular determinants of signal transduction in tropomyosin receptor kinases
Tropomyosin receptor kinase (Trk) receptors are essential regulators of neuronal development, survival, and plasticity through their interactions with neurotrophins. This review examines the structural and molecular mechanisms connecting ligand binding to the diverse signaling outcomes of Trk…
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Artikel Jurnal
Interplay between RNA‐protein interactions and RNA structures in gene regulation
Cellular RNAs are not linear single‐stranded stretches of nucleic acids as depicted in textbook cartoons but fold into secondary and tertiary structures through intra‐ and intermolecular base‐pairing. They also interact with proteins to form ribonucleoproteins (RNPs), the functional units of RNA in…
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Artikel Jurnal
The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro
In this study, we aimed to investigate the effect of salubrinal (SAL) on endoplasmic reticulum stress via an experimental in vitro heat stress model (HSM) of spermatogenic cells. In order to achieve this, mouse spermatogonium (GC1) and spermatocyte (GC2) cell lines were used. The IC50 dose of SAL…
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Artikel Jurnal
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
Vascular barrier disruption is a hallmark of diseases such as cardiovascular disease, stroke, hypertension, pulmonary disorders, infections, and cancer. Endothelium permeability is tightly regulated by shear stress, allowing tissue perfusion, while disturbed flow leads to increased permeability…
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Artikel Jurnal
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
Cardiovascular diseases, including thrombotic events such as ischemic stroke, pulmonary embolism, and myocardial infarction, are among the leading causes of morbidity and disability worldwide. The application of clot‐dissolving thrombolytic enzymes is a cost‐effective therapeutic intervention for…
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A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
The mechanisms of reversible inhibitors with a single binding site on enzymes are usually divided into two basic groups: linear and hyperbolic (or partial). Each of these two groups is subdivided into three types: competitive, non‐competitive and mixed. These six mechanisms are often considered…
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Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage
Cdc10‐dependent transcript 1 (CDT1) is an essential protein for DNA replication licensing, which loads the mini‐chromosome maintenance (MCM) complex onto replication origins. We previously reported that excess CDT1 inhibits the elongation of nascent strands during DNA replication in Xenopus egg…
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Artikel Jurnal
Patatin‐domain‐containing (phospho)lipases under control: Mammalian co‐regulators and pathogenic activation mechanisms
Patatin‐like phospholipase (PNPLA) domain‐containing proteins are essential enzymes involved in lipid metabolism, membrane remodeling, and signaling pathways across various organisms. This review focuses on the structural and functional characteristics of four selected PNPLA proteins from different…
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Artikel Jurnal
Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival
Lactoferrin (Lf) is a multifunctional glycoprotein of the transferrin family which has shown to efficiently block cell migration and/or invasion in a wide range of cancer cell models. The objective of this study was to further understand how Lf targets cancer cells by examining the effect of…
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Artikel Jurnal
Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming
Primary fibroblasts are widely used in a variety of experimental and therapeutic studies. Patient‐derived skin biopsies are an accessible way to generate dermal fibroblasts for wound and burn therapeutics and can be easily reprogrammed to induced pluripotent stem cells (iPSCs). Despite the…
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Artikel Jurnal
Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families
In addition to transmitting receptor‐mediated signals to adjust the gene expression profile of the cell, small GTPases of the Ras family also control the remodelling of the actin cytoskeleton. The conversion of Ras GTPases from their active to their inactive form is controlled by Ras…
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Microfluidic electro‐viscoelastic manipulation of extracellular vesicles
Microfluidic technology has created new opportunities for developing innovative tools for biological applications. Given the significance of extracellular vesicles (EVs), extensive research has focused on developing microfluidic techniques for EV isolation. This research protocol presents…
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Artikel Jurnal
Homologous expression and purification of human HAX‐1 for structural studies
The human HAX‐1 protein is a ubiquitously expressed multifunctional protein that regulates various cellular processes through interactions with numerous cellular proteins and RNA. The purification protocol presented here is designed explicitly for HAX‐1 expressed in mammalian cells and yields high…
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Artikel Jurnal
Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education
The rapid shift to online and blended learning in higher education has led to the development and use of digital tools that support student engagement and learning outcomes. This systematic review examines the effectiveness of these digital tools across various disciplines in higher education…
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Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice
The predominant cause of death among diabetic patients comes from cardiovascular complications, including vascular calcification. The objectives of this study were to improve the understanding of the molecular mechanisms involved in diabetes‐related calcification and to test potential preventive…
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Artikel Jurnal
Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe
Treacher Collins syndrome (TCS) is a rare congenital disorder characterized by craniofacial deformities. Although mutations in several genes involved in ribosome biogenesis have been identified in patients with TCS, the molecular mechanisms underlying their effects remain poorly understood. In this…
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Artikel Jurnal
Naked cuticle is essential for Drosophila wing development beyond Wingless signaling
The evolutionarily conserved gene naked cuticle (nkd) has been gone through studies in both invertebrate and mammalian model systems. Nkd proteins play an essential role in the development of Drosophila as a negative‐feedback regulator for Wingless signaling. In this research study, we showcase the…
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