1.373 hasil
Menampilkan 1–20 · 0,17 detik · RSS
Journal of Orthopaedic Translation
Scopus
ISSN 2214-031X · Elsevier · 1.373 artikel di indeks
-
Artikel Jurnal
Functional biomaterials for the treatment of periprosthetic joint infection: A systematic review of preclinical animal studies
Background: Periprosthetic joint infection (PJI) is a serious complication following joint arthroplasty, often leading to implant failure, bone destruction, and high revision rates. Conventional treatments are limited by biofilm persistence and collateral tissue damage. Functional biomaterials…
-
Artikel Jurnal
Brain–bone axis dysregulation: Biological code underlying the bidirectional association between depression and musculoskeletal disorders
Depression and musculoskeletal disorders including osteoporosis (OP), fractures, osteoarthritis (OA) and rheumatoid arthritis (RA) exhibit significant bidirectional epidemiological and pathophysiological links. Rising depression prevalence (approximately 2.7 % annually) is accompanied by the high…
-
Artikel Jurnal
Schwann-endothelial crosstalk in neurovascularized cell sheets induced host CGRP release to drive mandibular bone regeneration
Background: Mandibular defects resulting from trauma, tumors, and infections present a considerable clinical challenge, profoundly affecting patients' psychological and physical well-being. Native bone tissue relies on tightly coordinated neurovascular crosstalk to regulate bone development…
-
Artikel Jurnal
The brain–gut–joint axis in arthritis: crosstalk, treatment, and future perspectives
Arthritis is an inflammatory disease that affects the joints and often leads to disability and dysfunction, significantly impacting human health. The brain-gut-joint axis is a complex regulatory network that involves the joints and has a profound influence on the development of arthritic diseases…
-
Artikel Jurnal
Cell-based therapies for intervertebral disc degeneration: Navigating the path from promise to clinical reality
Low back pain (LBP) remains a leading contributor to global health loss, with its disease burden escalating steadily worldwide. Intervertebral disc degeneration (IDD) serves as the primary pathological basis for specific forms of LBP, driven by a multifactorial cascade involving molecular…
-
Artikel Jurnal
Global to local burdens, inequalities, and achievable frontiers of child and adolescent malignant neoplasm of bone and articular cartilage across 953 countries and sublocations, 1980–2040, with deep learning-based forecasts
Background: Malignant neoplasm of bone and articular cartilage (MNBAC), a major cause of cancer-related mortality, disproportionately impacts children and adolescents. However, comprehensive and future-oriented studies are still lacking. Methods: We systematically analyzed global-to-subnational…
-
Artikel Jurnal
Effects of early photobiomodulation therapy on motor recovery in patients with incomplete acute cervical spinal cord injury: A multicenter randomized controlled trial
Background: Early neurological recovery following acute incomplete cervical spinal cord injury (SCI) is associated with better long-term function. Photobiomodulation (PBM) has shown neuroprotective effects in preclinical studies, but multicenter clinical evidence remains limited. Methods: In this…
-
Artikel Jurnal
USP39 inhibits MLKL phosphorylation and deubiquitination to suppress necroptosis of nucleus pulposus cells and attenuate intervertebral disc degeneration
Background: Intervertebral disc degeneration (IVDD) is a leading cause of chronic low back pain. Programmed cell death, particularly necroptosis, contributes to nucleus pulposus (NP) cell loss. Mixed lineage kinase domain-like protein (MLKL) phosphorylation plays a critical role in necroptotic…
-
Artikel Jurnal
Intermittent intra-articular delivery of FGF8b enhances cartilage homeostasis and attenuates osteoarthritis progression
Objective: Osteoarthritis (OA) is a chronic disease characterized by degeneration of articular cartilage, affecting over half a billion individuals globally. Current treatments such as non-steroidal anti-inflammatory drugs are effective in symptom relief, but lack the ability to modify OA…
-
Artikel Jurnal
VEGF-neutralized platelet-rich plasma with adipose-derived stromal vascular fraction enhanced osteochondral repair in a point-of-care goat model
Background/objective: Focal articular cartilage defects do not heal spontaneously. Platelet-rich plasma (PRP) is as an autologous source of growth factors that has been reported to promote tissue healing. However, PRP contains angiogenic factors such as vascular endothelial growth factor (VEGF)…
-
Artikel Jurnal
Oxidative stress and bone marrow adipocytes: Molecular mechanisms and possible implications
Redox homeostasis is crucial for maintaining cellular processes and is closely linked to human skeletal health. Prior research has demonstrated that oxidative stress is important for regulating osteoblast and osteoclast differentiation in the bone microenvironment, leading to a reduction in bone…
-
Artikel Jurnal
Mitochondrial DNA released from pyroptotic synovial macrophages via DDIT3-mediated mitophagy aggravates osteoarthritis progression
Objective: Emerging evidence has shown that inflammatory synovial macrophage and anabolism-impaired chondrocytes play essential roles in osteoarthritis (OA). The present work aims at uncovering the pathogenic mechanism of how the damage-associated molecular patterns (DAMPs) released from…
-
Artikel Jurnal
Extracellular vesicles originating from induced pluripotent stem cell-derived chondrocytes facilitate the regeneration of osteoarthritic cartilage
Background: Articular cartilage, a highly specialized avascular connective tissue, forms a smooth, load-bearing surface on articulating bone ends to facilitate frictionless joint movement. While cell-derived small extracellular vesicles (sEVs) have emerged as promising therapeutic biomaterials for…
-
Artikel Jurnal
Graphene oxide-modified PEEK composites: Properties and applications in orthopaedic repair — A review
Critical-sized bone defect repair remains a major challenge in orthopaedics and tissue engineering. Polyetheretherketone (PEEK) has attracted wide attention due to its excellent mechanical compatibility and radiological transparency; however, its inherent bioinertness and insufficient antibacterial…
-
Artikel Jurnal
Plasma-derived exosomes from obese knee osteoarthritis aggravate synovitis by promoting cellular senescence of synovial fibroblasts
Objectives: As the most important risk factor for knee osteoarthritis (OA), obesity is closely associated with the clinical symptoms of OA. This study aims to systematically analyze the exosomal RNAs signatures in the plasma of knee OA patients with different body mass index (BMI) and to…
-
Artikel Jurnal
Asymmetrical paravertebral muscles fibrosis causes progression of adolescent idiopathic scoliosis via myostatin signalling in fibro-adipogenic progenitors
Background: Adolescent idiopathic scoliosis (AIS) is characterized by progressive spinal deformity; however, its underlying mechanisms are poorly understood. While asymmetry of the paravertebral muscles (PVMs) has been linked to AIS progression, its molecular basis remains unclear. Methods: PVMs…
-
Artikel Jurnal
Profibrotic macrophage-derived CXCL4 promotes pericyte-to-myofibroblast transition after spinal cord injury
Introduction: Spinal cord injury (SCI) induces fibrotic scarring that impairs axonal regeneration. Pericytes contribute to scar formation via pericyte-to-myofibroblast transition (PMT), yet the mechanisms underlying PMT in SCI remain unclear. Although CXCL4, a pleiotropic chemokine, is implicated…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.