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Human Pathology: Case Reports
ISSN 2214-3300 · Elsevier · 510 artikel di indeks
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Atypical histologic presentation of Pneumocystis pneumonia as granulomatous lung nodules
Pneumocystis jiroveci pneumonia (PJP) is classically described as presenting histopathologically as frothy intra-alveolar exudates. Less commonly, it can present with focal granulomatous lesions in patients with or without underlying acquired immune deficiency syndrome (AIDS). Here we present a…
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Immune biomarkers as an adjunct diagnostic modality of infection in cases of sudden and unexpected death in infancy (SUDI) at Tygerberg Medico-legal Mortuary, Cape Town, South Africa
Child mortality is a major health concern worldwide with over 4.2 million infants dying before reaching the age of one year in 2016 alone. Several international intervention initiatives have resulted in a decrease in the number of infant deaths; however, the incidence of sudden unexpected death in…
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Case of thyroid transcription factor-1-positive neuroendocrine carcinoma of the sphenoid sinus with bone metastases
Malignant tumors in the sinonasal region are rare and account for only 0.2–0.8% of all cancers and 1–3% of all head and neck carcinomas. Among the confirmed cases, the involvement of the sphenoid sinus is even rarer, accounting for only 2–3% of paranasal sinus tumors (Osguthorpe et al., 1994…
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TUBA1A-GLI1 fusion in a soft tissue myoepithelial neoplasm
Several types of benign and malignant neoplasms harboring GLI1 gene fusions with various partner genes, including ACTB, MALAT1 and PTCH1, have been described. These neoplasms show a spectrum of morphologic features and immunohistochemical profiles. However, the GLI1 gene fusion has not been…
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Primary anaplastic large cell lymphoma of the CNS as initial presentation of HIV infection: A case report
Primary anaplastic large cell lymphoma (ALCL) of the central nervous system (CNS) is a rare entity. Most primary CNS lymphomas are of B-cell origin, including those associated with HIV. We report a case of a 29-year-old woman who presented with worsening headaches and was subsequently diagnosed…
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Primary bilateral adrenal lymphoma masquerading as a metastatic melanoma: An unusual presentation of a rare disease
This report describes a 70-year-old male with bilateral primary adrenal lymphoma (PAL) characterized as non-germinal center diffuse large B-cell lymphoma (DLBCL). PAL is a very rare, aggressive disease with a poor prognosis. Our patient presented with B symptoms, chills, and nausea. Imaging studies…
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VCL-ALK renal cell carcinoma in adult patient without sickle cell trait
Anaplastic lymphoma kinase rearrangement-associated renal cell carcinoma (ALK-RCC) is a provisional renal cell carcinoma subtype with a growing list of published fusion partners. VCL-ALK gene fusion represents an uncommon fusion partner (only 6 reported cases), almost always associated with sickle…
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ALK-positive histiocytosis of the umbilicus with KIF5B-ALK fusion: A case report and review of the literature
Background: Since the first report in 2008 of cases of anaplastic lymphoma kinase (ALK)-positive histiocytosis, originally described as a systemic, self-limiting disease in infants, the range of ALK-positive histiocytosis has been expanded to include localized diseases in older children and adults…
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Osteosarcoma with Telangiectatic Features Metastatic to the Small Bowel
Herein, we present the case of a 35-year-old man with a previous history of osteosarcoma of his left tibia followed by multiple episodes of bilateral pulmonary metastases. After being clinically free of disease for seven years, the patient developed a 23 cm mass involving his small bowel wall. To…
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Dedifferentiated gastrointestinal stromal tumour with features mimicking malignant PEComa/alveolar soft part sarcoma: An unusual type of morphological transformation following imatinib treatment
Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. Dedifferentiation is a rare phenomenon in GISTs, most often following long-term Imatinib therapy and less frequently in de-novo fashion. According to the literature, the process of…
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Giant placental chorangioma: The first case report in Indonesia
Giant placental chorangioma is a benign non-trophoblastic neoplasm which is rare but often results in serious prenatal complications and adverse pregnancy outcome. Here, we present the first case report of giant placental chorangioma in Indonesia with good clinical outcome, prenatally detected in a…
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Sibling donor-derived myeloid sarcoma after hematopoietic stem cell transplant
Donor-derived myeloid sarcoma (DDMS) is a rare complication which occurs when donor stem cells undergo leukemic transformation. We report here two cases of DDMS following successful allogenic hematopoietic stem cell transplant (allo-HSCT) from HLA-identical, sex-mismatched sibling donors. Both were…
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Atypical spindle cell/pleomorphic lipomatous tumor of the stomach: A case report
Atypical spindle cell/pleomorphic lipomatous tumor (ASPLT) is a newly accepted entity that belongs to the group of low-grade adipocytic neoplasms. ASPLT commonly manifests a soft tissue mass in both upper and lower extremities but is extremely rare in the gastrointestinal tract. Here we report a…
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Metastatic pulmonary tumor from type 3 gastric neuroendocrine tumor
Type 3 NETs are reported to metastasize to other organs or lymph nodes; however, there are few reports of gastric NETs causing isolated pulmonary metastasis. We report a rare case of primary gastric neuroendocrine tumors (NETs) with lung metastasis. The patient presented with multiple gastric…
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Type B3 thymoma associated membranous nephropathy: A rare case and review of the literature
Thymoma can cause several autoimmune conditions in a number of patients. Nephrotic syndrome is considered to be a rare systemic manifestation from thymic lesions. The most common renal pathology associated with thymoma is minimal change disease (MCD). Herein, we reported a case of 58-year-old man…
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Simultaneous colonic T-cell lymphoma and graft-versus-host disease: A rare diagnosis
Cutaneous T-cell lymphoma (CTCL) presenting as mycosis fungoides is typically localized to the skin and occasional draining lymph nodes. We present a 46-year-old man with refractory CTCL status-post allogeneic stem cell transplant who was biopsied for diarrhea and abdominal pain. These…
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A massive 13.5 cm sclerosing pneumocytoma in a 61-year-old female
Sclerosing pneumocytoma (previously called pulmonary sclerosing hemangioma) is a very rare benign pulmonary neoplasm. Diagnosis of this tumor can be problematic especially on the small biopsy specimens. Here, we report a massive 13.5 cm sclerosing pneumocytoma in a 61-year-old female who presented…
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A case of retroperitoneal lymphangioma in an adult
Retroperitoneal lymphangiomas are uncommon lymphatic malformations that present as cystic masses, arise from isolated lymphatic vessels, and do not communicate with the normal lymphatic system. We report a rare case of retroperitoneal lymphangioma in a young man who presented with abdominal pain…
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Rare presentations and literature review of Rosai Dorfman disease of the breast
Introduction: Rosai-Dorfman disease (RDD) is a rare, idiopathic, proliferative disorder of histiocytes usually involving head-neck lymph nodes. It can also involve extra nodal sites like skin, nasal sinuses, and soft tissue. It rarely affects the breast. Case presentation: We present three unusual…