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Journal of Clinical & Translational Endocrinology
Scopus
ISSN 2214-6237 · Elsevier · 426 artikel di indeks
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Artikel Jurnal
Systemic MOTS-c levels are increased in adults with obesity in association with metabolic dysregulation and remain unchanged after weight loss
Introduction: MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a mitochondrial-derived peptide and regulator of metabolic homeostasis. Although its role in glucose and lipid metabolism is emerging, changes in circulating MOTS-c with obesity remain unclear. We hypothesized that…
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Identification of novel and recurrent mutations in nicotinamide nucleotide transhydrogenase (NNT) underlying familial glucocorticoid deficiency-type 4 in multiple Saudi families
Background: Familial glucocorticoid deficiency (FGD; MIM: 614736) is a genetic disease of glucocorticoid insufficiency, with autosomal recessive mode of inheritance. The FGD is genetically heterogeneous disorder that involves multiple genes related to the pathway that regulates the signaling from…
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Remnant cholesterol inflammatory index and MASLD in U.S. adults: mediation role of triglyceride-glucose index
Background: Metabolic dysfunction–associated steatotic liver disease (MASLD) is driven by dyslipidemia and chronic inflammation. We proposed a novel biomarker, the Remnant Cholesterol Inflammatory Index (RCII), and evaluated its association with MASLD, considering mediation via insulin resistance…
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Effects of cyclic yoga on selected metabolic and hepatic parameters in diabetic women with fatty liver diseases: A clinical trial
Aims: Type 2 diabetes mellitus and non-alcoholic fatty liver disease increase cardiometabolic risk. This randomized controlled trial assessed the effects of cyclic yoga, a structured asana sequence, on anthropometric, glycemic, lipid, and hepatic parameters in overweight women with both conditions…
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Implementation of a Best Practice Advisory to alert inpatient providers of necessary discharge prescriptions for insulin and supplies for patients with diabetes
Background: Medication discrepancies and omissions at hospital discharge are a common, preventable source of harm for patients with diabetes. Ensuring accurate prescriptions for insulin and diabetes supplies is critical for safe transitions of care. We aimed to evaluate the impact of a Best…
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Continuous glucose monitoring reveals high prevalence of hyperglycaemia in patients prior to pancreatic surgery: A pilot study
Aims: Patients with pancreatic tumours are at increased risk of diabetes mellitus (DM) and hyperglycaemia and a subsequent higher risk of developing postoperative complications. Continuous glucose monitoring (CGM) can be used to assess the prevalence of hyperglycaemia in pancreatic surgery…
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High plasma levels of soluble triggering receptor expressed on Myeloid Cells 2 were associated with depression in patients with newly diagnosed type 2 diabetes mellitus
Aims: The hypothesis was that depressed patients compared to non-depressed patients with newly diagnosed type 2 diabetes mellitus (T2DM) had higher levels of soluble Triggering Receptor Expressed on Myeloid Cells 2 (sTREM2) as a sign of increased microglial activation. The aim was to explore a…
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Post-exercise hypoglycaemia in adults with cystic fibrosis compared to healthy control adults
Background: People with cystic fibrosis-related diabetes (CFRD) are at risk of hypoglycaemia related to insulin therapy; and hypoglycaemia is also prevalent in those without CFRD. Although people with other forms of diabetes mellitus are at risk of hypoglycaemia within 48 h after exercise, this has…
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Impact of gender-affirming hormone therapy on dry eye
Purpose: To determine whether gender-affirming hormone therapy (GAHT) influences tear system health in transgender individuals. Methods: This retrospective cohort observational study analyzed data from transgender men and women ages ≥18-years between 2004 and 2024 via electronic medical record…
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Thyroid cancer and double-strand DNA break repair: The potential role of the MRN complex pathogenic variants
The molecular drivers of thyroid cancer are predominantly involved in the MAP kinase pathway, especially the BRAF and RAS pathogenic variants. The DNA repair pathways are rarely implicated in thyroid tumorigenesis. The MRE11-RAD50-NBS1 (MRN) complex is a key mediator of homologous recombination…
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Change in circulating irisin level and its association with lipid metabolism after exenatide treatment in patients with type 2 diabetes mellitus
Background: Irisin is a metabolism-related myokine associated with lipid metabolism and insulin resistance. However, its changes during glucagon-like peptide-1 (GLP-1) receptor agonist therapy remain unclear. Methods: This exploratory analysis of a multicenter trial included 189 adults with T2DM…
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Temporal changes in circulating miRNAs following gestational diabetes diagnosis: a pilot longitudinal study
Currently, no clinical early predictive biomarkers of GDM exist. A key challenge is that many candidate biomarkers fluctuate during pregnancy. Previous studies with a single time point identified several miRNAs in early pregnancy associated with insulin sensitivity between 24 and 29 weeks of…
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Prevalence of overweight and obesity in a South Texas cystic fibrosis center
Background: Overweight and obesity rates have increased drastically among people with cystic fibrosis (CF), in part due to advancements in care, including highly effective modulator therapies (HEMT). Ethnic differences in the prevalence of overweight/obesity in CF are unknown. Methods: To determine…
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Transition to adult diabetes care for young adults with type 2 diabetes: Challenge and opportunity
Transition from pediatric to adult care is a critical period for young adults with type 2 diabetes mellitus (T2DM). This study included a retrospective chart review of 139 patients aged 17–25 years with T2DM followed in pediatric endocrinology between 2021 and 2022. Patients were categorized as…
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Growth hormone-releasing hormone, growth hormone, and neuroendocrine tumors
Neuroendocrine tumors (NETs) are known to produce growth hormone (GH) and growth hormone-releasing hormone (GHRH) leading to acromegaly. Ectopic production of these hormones can lead to ectopic acromegaly which is very rare. Ectopic acromegaly secondary to GHRH has been studied more extensively…
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Increased cytokine production capacity and persistent inflammation after achieving remission of Cushing’s syndrome
Endogenous Cushing’s syndrome (CS) is characterized by chronic hypercortisolism. After achieving remission, morbidity remains increased and quality of life remains impaired. Moreover, the incidence of inflammatory disorders increases after remission of CS. Despite these immune-mediated clinical…
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Somatic genomic profiling reveals clinically relevant heterogeneity in RAS-mutant sporadic medullary thyroid carcinoma
Objective: Sporadic medullary thyroid carcinoma (sMTC) is predominantly driven by somatic RET or RAS mutations, although the molecular basis of disease heterogeneity remains incompletely understood. Our study aims to characterize molecular heterogeneity in sMTC in order to identify pathways that…
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Suboptimal osteoporosis screening rates persist in patients on long-term glucocorticoid therapy: current experience within an academic health system
Background: Glucocorticoid-induced osteoporosis (GIO) is a serious complication of long-term glucocorticoid therapy. Although the risks of glucocorticoid therapy are well recognized, screening rates for GIO are low. Objective: This study aimed to evaluate the current state of GIO screening in…
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Artikel Jurnal
Urinary neutrophil Gelatinase–Associated lipocalin as an early and reliable biomarker of diabetic nephropathy in type 2 diabetes mellitus
Background: Early detection of diabetic nephropathy (DN) remains a major clinical challenge. Conventional indicators such as serum creatinine and urinary albumin excretion often identify renal impairment only after significant structural damage has occurred. Increasing evidence suggests that…
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Body weight and waist circumference are differentially associated with the response to L-thyroxine treatment in primary hypothyroidism
Background: Thyroid hormones (TH) and neurotransmitter orexin (ORX) are implicated in the regulation of metabolism. Abdominal weight gain is common in primary hypothyroidism (PH). Methods: Our aim was to investigate whether TH affected peripheral weight gain, waist circumference (WC) and…