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Toxicology Reports
Scopus
ISSN 2214-7500 · Elsevier · 2.220 artikel di indeks
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Artikel Jurnal
Polycyclic aromatic hydrocarbon exposure in battlefield and beyond: Implications for environmental- and human health
Polycyclic aromatic hydrocarbons (PAHs) are combustion pollutants that are released into the environment through natural events and anthropogenic activities. Exposures to PAHs occur in military personnel during garrison (non-combat) and active deployment (combat) environments. Exposures that occur…
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Heated tobacco product aerosol emission compared to cigarette smoke: A scoping review
Heated tobacco products (HTPs) are promoted as reduced-risk alternatives to combustible tobacco cigarettes (TCs), yet toxicant exposure reduction and associated health benefits remain uncertain. We evaluated preclinical and interventional clinical studies comparing HTPs with TCs, focusing on…
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Investigation of serum concentration and the type of opioid used in patients with opium poisoning
Opioid poisoning constitutes a major public health issue in Iran and worldwide, with increasing rates attributed to both traditional opiates and synthetic derivatives such as methadone. Reliable assessment of serum opioid concentrations is essential for clinical management and prognosis…
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Circulating miR-126 and miR-155 are associated with environmental lead exposure: A translational approach via human biomonitoring and bioinformatic networks
Exposure to environmental contaminants, particularly lead (Pb), has increased due to anthropogenic activities and has been associated with epigenetic alterations, including changes in microRNA (miRNA) expression. Certain miRNAs have emerged as potential biomarkers of environmental exposure and…
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Runaway uncoupling in 2,4-dinitrophenol poisoning: Clinical and mitochondrial observations from two cases
2,4-Dinitrophenol (DNP) is a potent mitochondrial uncoupler briefly marketed in the 1930s as a weight-reducing agent before being banned by the FDA after reports of severe toxicity. Since the early 2000s, DNP has reemerged as an illicit “fat-burner”, causing characteristic metabolic disturbances…
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Can in silico models predict drug-induced cardiac risk in vulnerable populations?
This study evaluates virtual cardiac populations for preclinical assessment of drug-induced QT interval prolongation and arrhythmic risk. Traditional predictions often rely on small, healthy cohorts, excluding vulnerable populations. Using computational models of realistic heart anatomies and…
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Toxicological effects of volatile organic compounds are mediated by aggravated oxidative stress and neuroinflammatory processes in piglets
Anthropogenic and natural sources of volatile organic compounds (VOCs) have been associated with hematological, cardiovascular, and respiratory diseases. VOCs can also track directly from the nose to the olfactory bulb (OB). This study investigated whether inhaled VOC-induced toxicity increases…
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Fatal nicotine poisoning with an extremely high first available serum nicotine concentration and serial nicotine/cotinine measurements: A case report
Human toxicokinetic data after massive nicotine exposure are scarce, and the relationship between circulating nicotine kinetics and organ-specific pathophysiology remains poorly understood, particularly in the post–cardiac arrest setting. We report a fatal case of a 36-year-old woman found…
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Acute effect of tetracycline on systemic stress markers and organ histopathology in juvenile Nile tilapia, Oreochromis niloticus
Antibiotic contamination in aquaculture systems frequently encounter severe threat to aquatic life including fish. This study aimed to evaluate acute toxicological effects of tetracycline in juvenile Nile tilapia, Oreochromis niloticus. We exposed ten fish in each tank with nominal tetracycline…
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Berberine nanoemulsion against nephrotoxicity induced by bisphenol a in rats during pre-puberty stage
This study evaluated the effects of berberine nanoemulsion (BNE) against nephrotoxicity induced by bisphenol A (BPA), a plastic chemical, in rats during the pre-puberty stage. Thirty-six male Wistar rats (23-day-old) were randomly allocated to six groups (n = 6): Group 1 (Control). Group 2 (BPA)…
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Unveiling melatonin’s multifaceted actions against ferroptotic neurotoxicity in ischemic stroke
Ferroptosis, an iron-mediated form of programmed cell death, is increasingly recognized for its role in neurodegenerative diseases, with relevance to ischemic stroke, a condition that creates a permissive environment for this process. The prevalence of ischemic stroke is steadily increasing, with…
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Direct adverse effects of fipronil sulfone, diisopentyl phthalate and disperse red 60 on zebrafish hepatocytes
The major concerns about emerging pollutants fipronil sulfone, disperse red 60 (DR60), and diisopentyl phthalate (DiPP) include their environmental persistence, difficulty in its removal from water sources, and bioaccumulation in aquatic organisms. They could eventually enter the food chain and…
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The toxicology of orally administered Δ9-tetrahydrocannabinol in sheep
Introduction: As part of a larger study to assess the potential value of industrial hemp biomass (the low Δ9-tetrahydrocannabinol (Δ9-THC) variety of Cannabis sativa L.) as a feed for ruminants, a pharmacokinetics study of Δ9-THC, one of the main cannabinoids of interest, was undertaken. In…
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L-Methionine attenuates methotrexate-induced cardiotoxicity by modulating oxidative stress, inflammation, and dyslipidemia in rats
Methotrexate (MTX) is a potent chemotherapeutic agent with a wide range of anticancer effects; however, its clinical efficacy is restricted due to its cardiomyopathy. This research examined the protective potential of L-Methionine (L-Met) against MTX cardiotoxicity in rats. Thirty rats were…
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Rutin outperforms gallic acid in mitigating carbon tetrachloride-induced nephrotoxicity: Integrated in silico (docking, MD simulations, DFT) and in vivo mechanistic validation
Background: Carbon tetrachloride (CCl₄) induces nephrotoxicity via oxidative stress and inflammation. Aim: This novel comparative study evaluated the nephroprotective efficacy of rutin and gallic acid (GA) against CCl₄-induced kidney damage by elucidating their antioxidant and anti-inflammatory…
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Blood lead exposure, renal hyperfiltration, and accelerated kidney function decline among people living with HIV in northern Tanzania: A longitudinal cohort study
Introduction: People living with HIV (PLWH) face a high burden of kidney disease from HIV-related injury, antiretroviral toxicity, and environmental lead exposure. Renal hyperfiltration, an early compensatory state, may precede accelerated kidney function decline, yet its relationship with lead…
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Sub-acute dihydroxyacetone exposure alters mitochondria and induces cardiac strain
Dihydroxyacetone (DHA), a carbohydrate detected in e-cigarette aerosols and used in sunless tanning products, is genotoxic and cytotoxic in various cell models. We previously demonstrated that inhaled DHA induced lung injury in A/J mice. Here, we evaluated cardiac effects of sub-acute DHA exposure…
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Effects of lawsone and lawsone methyl ether on cyclooxygenase activity, redox balance, and organ-specific toxicity: An integrated computational and experimental study
Redox imbalance contributes significantly to the initiation and progression of inflammatory responses. Although conventional anti-inflammatory drugs are widely used, their prolonged administration is associated with a number of adverse effects. Lawsone methyl ether (LME) and lawsone are…
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Pulmonary function assessment of a community exposed to air pollution in an industrial area in Ouagadougou, Burkina Faso
Industrial air pollution has been linked to respiratory diseases due to pulmonary function impairment, which are poorly documented in low-and middle-income countries. This study aimed to assess the pulmonary function of a community exposed to air pollution in an Industrial Area (IA) in Ouagadougou…
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Artikel Jurnal
Acute, high dose ethylene glycol administration produces no neuroinflammation, no abnormal brain or liver histology, significant urinary oxalate excretion, and minimal nephrotoxicity in male CD-1 mice
The hallmarks of ethylene glycol (EG) toxicity are very well characterized in rat and female mouse models, and includes glycolate-mediated metabolic acidosis with calcium oxalate monohydrate (COM) target-organ accumulation. However, high dose, acute EG target organ toxicity has yet to be assessed…
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