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Scientia Pharmaceutica
Scopus
ISSN 2218-0532 · MDPI AG · 577 articles in the index
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UHPLC-UV Method for Vancomycin Quantification in Human Plasma by Simple Protein Precipitation: Development and Validation for Therapeutic Drug Monitoring
Vancomycin (VCN) is a glycopeptide antibiotic widely used to treat Gram-positive infections such as those caused by methicillin-resistant Staphylococcus aureus (MRSA). Its narrow therapeutic window, high interindividual pharmacokinetic variability, and dose-dependent nephrotoxicity support the need…
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Antiplasmodial Potential of Compounds from the Bark of Mitragyna inermis (Rubiaceae): In Silico and In Vitro Studies Against LDH, PKG Enzymes and 3D7/Dd2 Strains
Background: Plasmodium falciparum, the most virulent malaria parasite, continues to develop resistance to available drugs. Mitragyna inermis (Rubiaceae) is traditionally used in Africa for the treatment of malaria and has shown antiplasmodial activity against P. falciparum. Previous studies on this…
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Development and Optimization of a Self-Nano-Emulsifying Drug-Delivery System (SNEDDS) of Ibuprofen by Implementing a Box–Behnken Experimental Design
Ibuprofen is a widely used non-steroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and anti-inflammatory activity; however, its low aqueous solubility limits its dissolution rate and, consequently, its oral bioavailability. This study aimed to develop and physicochemically…
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1,12-Bis-Triphenyl Phosphonium Dodecane Bromide Nanovesicles as Potential Inhibitors of MDR Staphylococcal Biofilms
Multidrug resistance (MDR) has become a major global health threat, leading to the emergence of difficult-to-treat bacterial “superbugs” among both Gram-positive and Gram-negative species. In hospital settings, biofilm (BF)-producing staphylococci further aggravate this problem by markedly…
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Monoclonal Antibody Therapies in Chronic Inflammatory Diseases: Periodontal Outcomes, Oral Safety, and Clinical Implications—A Scoping Review
Monoclonal antibody-based therapies are widely used in chronic immune-mediated diseases, but their periodontal effects, dentoalveolar safety signals, and exposure characteristics remain incompletely characterized. This scoping review mapped periodontal clinical outcomes, biomarkers, microbiological…
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Structural Characterization and Cytotoxic Effects of Bioactive Compounds Isolated from Caulerpa sertularioides Against Human Cancer Cell Lines
Compounds isolated from the macroalga Caulerpa sertularioides have been reported to exhibit cytotoxic activity. The objective of this study was to assess the antioxidant effects of compounds isolated from C. sertularioides as well as their antiproliferative effect against cancerous cell lines and…
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The Role of Phenolic Compounds in NF-κB, Nrf2, and STAT3 Transcription Factors Regulation: Therapeutic Potential and Limitations in Cancer Treatment
Cancer is still one of the major causes of death globally. While there are many cancer therapies, they often come with significant adverse effects and limitations. A lot of studies have shown that using natural products can improve the efficacy of conventional therapies and decrease their toxicity…
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Integrated Pharmacognostic, LC-MS Metabolomic Profiling and Biological Evaluation of Elymus repens (L.) Gould
Elymus repens (L.) Gould has a long history of use in traditional medicine across the British Isles, particularly among Gaelic and Anglo-Saxon communities, where it has been employed as a diuretic and anti-inflammatory agent. Despite its ethnopharmacological significance, comprehensive insights…
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Translating the Properties of Physicochemical Dressings into Clinical Decision-Making for Heavily Exuding Wounds
Introduction: Heavily exuding wounds can macerate perilesional skin and favour infection. Information on the properties and use time of dressings should be clear and available to healthcare providers. Methods: Our aim was to evaluate the updated series of the AQUACEL® dressing family, because their…
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Potential Ligands to 3-Dehydroquinate Dehydratase (SaDHQD) of Staphylococcus aureus, Evaluated by Molecular Docking and In Vitro Assays to Develop an Antibiotic Drug
The World Health Organization (WHO) estimates that by 2050, bacterial resistance will cause 10 million deaths, of which approximately one million are associated with multidrug-resistant (MDR) microorganisms. Staphylococcus aureus is one of the bacteria with high resistance to the most widely used…
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Phytochemical Study and Cytotoxic Properties of Hydroalcoholic Extracts of Epilobium parviflorum Schreb.: In Silico and In Vitro Insights
Epilobium parviflorum Schreb. is a medicinal plant used traditionally against inflammatory disorders whose cytotoxic potential is still incompletely revealed. The current study investigates the phytochemical composition and in vitro cytotoxic activity of four hydroalcoholic extracts prepared from…
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Native Tapioca Starch Agglomerated Using Its Gelatinized Dispersion for Tablet Production by Direct Compression
This study aimed to investigate the physical properties of native tapioca starch (TS) ag-glomerated using its gelatinized dispersion as an agglomerating agent and to evaluate the performance of the resulting agglomerate tablets. The results demonstrate that TS agglomerated with gelatinized tapioca…
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Development and Microstructural Analysis of Rapid-Release Acanthus montanus Effervescent Mouthwash Tablets for Oral Care
The translation of underutilized botanical resources into advanced therapeutic dosage forms represents a critical frontier in pharmaceutical sciences. This study systematically characterizes the phytochemical and biological profiles of three Acanthus species (Acanthus ebracteatus, Acanthus…
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Cytokines, the Tumor Microenvironment, and Selected Plant-Derived Natural Products
Cytokines are produced by immune and other cells and work as cellular messengers to regulate an immune response and other biological processes. As the main components of the tumor microenvironment (TME), cytokines are involved in the major events of cancer development, including cancer and cancer…
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Tea Beverage-Dependent Reduction in Risperidone Concentration Following Mixing with Risperidone Oral Solution
Risperidone (RIS) oral solution has a bitter taste and is sometimes mixed with beverages to improve palatability and medication adherence. Although the package insert advises against mixing with tea beverages, the effects of beverage type and tea leaf variety on RIS concentration remain unclear…
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Quinoline Scaffold in Drug Discovery: Synthetic Strategies, Therapeutic Applications, and Emerging Drug Candidates
Quinoline is a bicyclic aromatic heterocycle composed of a fused benzene and pyridine ring, and it has held an important place in medicinal chemistry for nearly two centuries. F. Runge first isolated it from coal tar in 1834, and it was later found to form the structural core of well-known natural…
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Orotic Acid–1,2,4-Triazole Hybrids as Potential MMP-2,9 Modulating Wound-Healing Agents: Synthesis, Molecular Docking and Biological Evaluation
The matrix metalloproteinases MMP-2 and MMP-9 are involved in extracellular matrix remodeling, inflammatory response, and tissue remodeling, and overactivity of certain metalloproteinases may also contribute to chronic wound healing. The aim of this work was to synthesize novel hybrid derivatives…
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Development and Validation of a Capillary Zone Electrophoresis Method with Indirect UV Detection for the Simultaneous Determination of Azelaic Acid and Salicylic Acid in Pharmaceutical and Cosmetic Preparations
Azelaic acid (AZA) and salicylic acid (SA) are widely used active ingredients in pharmaceutical and cosmetic formulations for the treatment of acne, rosacea, hyperpigmentation, and other dermatological conditions. Despite their frequent co-administration, analytical methods for their simultaneous…
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Identifying and Evaluating Flavonoids as Potential Inhibitors of SARS-CoV-2 Main Protease (Mpro/3CL) Through Docking and Molecular Dynamics
Although the acute phase of the SARS-CoV-2 pandemic has subsided, the continued emergence of viral variants underscores the need for structurally diverse antiviral inhibitors. In this study, molecular docking followed by molecular dynamics (300 ns) simulations and binding free energy calculations…
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Bioactive Properties and Pharmaceutical Potential of New World Mistletoes of the Genus Tristerix: A Review
Mistletoes of the genus Tristerix, native to South America, represent a unique group of mostly hemiparasitic plants with potential medicinal applications. This review synthesizes existing knowledge on their biological and phytochemical properties, focusing on three main species endemic to Chile…