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Asian Pacific Journal of Tropical Biomedicine
Scopus
ISSN 2221-1691 · Wolters Kluwer Medknow Publications · 1.384 artikel di indeks
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Artikel Jurnal
Hypolipidemic and antioxidant potential of Trigonella foenum-graecum leaf extract via MAPK/JNK signaling pathway in high-fat diet-induced obese rats
Objective: To determine the qualitative and quantitative phytochemical components in the aqueous leaf extract of Trigonella foenum-graecum L. (AqE-TFG) and evaluate its therapeutic potential against high-fat diet-associated dyslipidemia in high-fat diet-induced obese rats. Methods: A total of 24…
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Artikel Jurnal
Antiviral activity of Sonchus arvensis L. extracts on dengue virus replication
Objective: To investigate the antiviral potential of Sonchus arvensis L. extracts against dengue virus (DENV)-1 and DENV-2 in vitro, and elucidate its underlying antiviral mechanisms. Methods: The cytotoxicity of the ethanol, ethyl acetate, and n-hexane extracts of Sonchus arvensis L. was…
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Artikel Jurnal
Multidrug-resistant Escherichia coli: Updated insights into resistance mechanisms, rapid diagnostics, and emerging control strategies
Multidrug-resistant (MDR) Escherichia coli (E. coli) is a major global health threat, causing increased morbidity, mortality, and healthcare burden. It is a common cause of community- and hospital-acquired infections, with a strong ability to acquire and disseminate resistance genes via horizontal…
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Artikel Jurnal
Synergistic effect of resveratrol and curcumin against doxorubicin-induced cardiac injury: Network pharmacology, molecular mechanisms and in-vivo evidence
Objective: To evaluate the cardioprotective effects of resveratrol and curcumin, individually and in combination, against doxorubicin- induced cardiac toxicity and explore the underlying mechanisms via network pharmacology. Methods: In silico target prediction, enrichment analyses, and Cytoscape…
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Artikel Jurnal
Catalpa ovata fruit extract promotes muscular differentiation and exercise performance: In vitro and in vivo study
Objective: To investigate the effect of Catalpa ovata fruit extract (COFE) on muscle growth and exercise performance in C2C12 myoblasts and mice. Methods: Cell viability was determined through a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Myogenic differentiation was…
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Artikel Jurnal
Curcumin attenuates pressure overload-induced cardiac fibrosis in mice via modulating the miR-29b/HDAC4 axis
Objective: To investigate the antifibrotic effects of curcumin in a transverse aortic constriction (TAC) mouse model and elucidate its molecular mechanisms. Methods: Male C57BL/6 mice underwent TAC and received vehicle, low-dose curcumin (50 mg/kg), high-dose curcumin (200 mg/kg), high-dose…
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Artikel Jurnal
Pharmacological activities of ruscogenin: A narrative review
Ruscogenin, a steroidal sapogenin, is primarily derived from the genus Ruscus. It demonstrates a wide range of pharmacological actions that hold substantial promise for therapeutic use. By conducting a comprehensive examination of electronic databases including PubMed, ScienceDirect, and SciFinder…
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Artikel Jurnal
Chikusetsusaponin IV protects against atherosclerosis by downregulating the NF-κB/ COX-2 and PI3K/AKT/mTOR signaling pathway
Objective: To investigate the anti-atherosclerosis effect of chikusetsusaponin IV (CSIV) against high-fat diet-induced atherosclerosis in rats. Methods: A high-fat diet was used for the induction of atherosclerosis in rats, and the rats received oral CSV or atorvastatin. The body weight, organ…
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Artikel Jurnal
Piceatannol-loaded self-nanoemulsifying drug delivery system accelerates wound healing in diabetic rats
Objective: To evaluate the effects of a piceatannol-loaded self-nanoemulsifying drug delivery system (PIC-SNEDDS) on wound healing in diabetic rats and its mechanisms of wound healing action. Methods: Diabetes was induced in rats using streptozotocin, after which full-thickness excisional wounds…
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Artikel Jurnal
Pituranthos chloranthus essential oil alleviates cisplatin-induced nephrotoxicity and potentiates antitumor activities: An in vivo and in vitro study
Objective: To study the potential of Pituranthos chloranthus essential oil (PC) as a chemoprotective agent. Methods: In the in vitro study, cell proliferation were determined in CT26, SW620, and SW480 cells. Cells were exposed to in-creasing concentrations of PC (0, 6.25, 12.5, 25, 50, 100, and 200…
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Artikel Jurnal
Oleanolic acid inhibits mitochondrial fission by improving mitochondrial dysfunction and reducing atherosclerosis via regulating AMPK/Drp1 pathway: An in vivo and in vitro study
Objective: To investigate effect of oleanolic acid (OA) on atherosclerosis and its related mechanisms. Methods: Human umbilical vein endothelial cells (HUVECs) were injured by oxidized low-density lipoprotein for 24 h and treated with OA, and the levels of cell proliferation, migration, adhesion…
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Artikel Jurnal
Nanotechnology-enabled delivery of phytoconstituents: Recent developments, applications, and regulatory considerations
Nanotechnology has revolutionized drug delivery, particularly through nanoformulations of phytoconstituents, enhancing their therapeutic potential. Despite their broad bioactivities, plant-based compounds often suffer from poor bioavailability and stability. Nanoformulations address these…
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Artikel Jurnal
Benzofuran-isatin derivative 5d acts as a dual-action agent in colorectal cancer cells by targeting EMT and mitochondrial apoptosis pathways
Objective: To investigate the anticancer effects of a novel benzofuran-isatin conjugate [N’-(5-methoxy-2-oxoindolin-3-ylidene)-3-methylbenzofuran-2-carbohydrazide (conjugate 5d)] against human colorectal adenocarcinoma (CRC) HT29 and metastatic SW620 colorectal cancer cells. Methods: The cytotoxic…
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Artikel Jurnal
Soybean oil ameliorates 4-octylphenol-induced endocrine disruption in female rats by increasing sex hormones, and reducing oxidative stress and inflammation
Objective: To determine whether soybean oil can ameliorate 4-octylphenol-induced alterations in female hormones, minerals, ovarian antioxidants, and inflammatory cytokines in female rats. Methods: Thirty-six female rats were divided into six groups: control, soybean oil (1 mL/rat), soybean oil (2…
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Artikel Jurnal
Metabolomics perspectives on natural product interventions for alleviating cardiovascular risks
Exploring natural products as therapeutic alternatives to synthetic drugs has garnered increasing research interest due to their reduced side effects and lower toxicity. Bioactive compounds derived from natural products exhibit a diverse range of pharmacological effects that help reduce…
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Artikel Jurnal
Ishige okamurae extract suppresses osteoclastogenesis in RANKL-induced bone marrow-derived macrophages and ovariectomized mouse model
Objective: To investigate the inhibitory effects of Ishige okamurae extract (IOE) against osteoclastogenesis in vitro and in vivo. Methods: The effects of IOE on osteoclast differentiation were examined in receptor activator of nuclear factor-KB ligand (RANKL)-stimulated bone marrow macrophages…
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Artikel Jurnal
Gomisin D alleviates podocyte injury in diabetic kidney disease by inhibiting oxidative stress via activation of the GSK3β (Ser9)/Nrf2/ARE signaling pathway
Objective: To explore whether gomisin D, a lignan derived from Schisandra chinensis, protects against podocyte injury in diabetic kidney disease and to elucidate its underlying mechanisms. Methods: Network pharmacology was employed to analyze the potential interactions between gomisin D and…
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Artikel Jurnal
Immune evasion in classical swine fever: Viral modulation of antigen-presentation pathways
Classical swine fever remains a major threat to global pig production systems, despite decades of sustained control endeavours. Its causative agent classical swine fever virus (CSFV) employs a highly coordinated set of immune evasion mechanisms to weaken host antiviral defences and permit extensive…
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Artikel Jurnal
Hantavirus disease: A review of global epidemiology, immunopathogenesis, clinical management, and future research priorities
Hantaviruses are rodent-borne zoonotic pathogens responsible for two major clinical syndromes: Hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome/cardiopulmonary syndrome. Although significant progress has been achieved in hantavirus research over recent decades, major…
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Artikel Jurnal
5-Fluorouracil loaded nanogels attenuate hepatotoxicity by modulating PI3K/AKT, NF-κB, and METTL14 pathways
Objective: To evaluate the effect of a gamma-irradiation-synthesized sodium alginate/acrylamide (SA/AAm) nanogel drug delivery formulation on 5-fluorouracil (5-FU)-induced hepatotoxicity. Methods: Network pharmacology analysis was used to identify overlapping 5-FU targets from the GeneCards and…
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