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International Journal of Ophthalmology
Scopus
ISSN 2222-3959 · Press of International Journal of Ophthalmology (IJO PRESS) · 3,831 articles in the index
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Integrating multiple key molecules in uveal melanoma to uncover metastatic and immune microenvironment-related gene signatures
AIM: To identify metastasis-associated prognostic genes and construct a robust molecular signature for survival prediction in uveal melanoma (UVM) patients. METHODS: Transcriptomic data and clinical information from 80 UVM patients in the Cancer Genome Atlas (TCGA)-UVM cohort and an external Gene…
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Visual field prediction using K-means clustering in patients with primary open angle glaucoma
AIM: To evaluate long-term visual field (VF) prediction using K-means clustering in patients with primary open angle glaucoma (POAG). METHODS: Patients who underwent 24-2 VF tests ≥10 were included in this study. Using 52 total deviation values (TDVs) from the first 10 VF tests of the training…
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Manual Bowman-stroma onlay transplant for the treatment of symptoms post-radial keratotomy: proof of concept and preliminary results
AIM: To describe the technique and the outcomes of manual Bowman layer and stroma transplant-onlay (BLST-o) for 2 cases of radial keratotomy (RK). METHODS: Two patients with visual fluctuations and corneal irregularity due to RK were offered manual BLST-o as an alternative to penetrating…
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Epidemiological investigative report on ocular morbidity in children in rural Kenya
AIM: To ascertain the pattern of ocular morbidity in a population of primary school children in rural Kenya as it is a prerequisite for planning effective preventive and therapeutic strategies. METHODS: A cross-sectional survey of ocular symptoms and clinical eye examinations were performed in a…
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Management of coexisting cataract and diabetic macular edema: a comparative study of dexamethasone implant versus anti-VEGF agents injections
AIM: To compare the anatomical and functional outcomes of combined phacoemulsification with intravitreal dexamethasone implant (DEX-I) versus anti-vascular endothelial growth factor (VEGF) injections in patients with diabetic macular edema (DME) and visually significant cataract. METHODS: This…
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A bibliometric analysis of publication trends in strabismus over the past 30y
AIM: To summarize publication trends in the field of strabismus over the past 30y and predict future research hotspots. METHODS: A total of 2915 English-language articles and reviews on strabismus, published between 1993 and 2022, were retrieved from the Web of Science Core Collection. Bibliometric…
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Acute zonal occult outer retinopathy complex and angioid streaks: a case report
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Lifestyle behaviors, serum metabolites and high myopia: Mendelian randomization and mediation analysis
AIM: To explore the causal relationship between several possible behavioral factors and high myopia (HM) using multivariable Mendelian randomization (MVMR) approach and to find the mediators among them with mediation analysis. METHODS: The causal effects of several behavioral factors, including…
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Pathophysiology of sildenafil-induced ocular toxicity in rats and treatment
AIM: To examine the ocular toxicity linked to sildenafil usage and the possible protective benefits of adenosine triphosphate (ATP) against this toxicity in rats. METHODS: Twenty-four male albino Wistar-type rats were divided into four equal groups (n=6/group) as follows: healthy group (HG)…
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Etiology and clinical analysis of secondary glaucoma: a single-center study from northwest China
AIM: To investigate the etiology and clinical characteristics of hospitalized secondary glaucoma (SG) patients in northwestern China. METHODS: A cross-sectional study was conducted involving SG patients hospitalized between July 2024 and January 2025. Clinical data were collected, including medical…
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Genetic analysis of Han-Chinese patients with isolated congenital ptosis
AIM: To conduct a genetic analysis of Han-Chinese patients with isolated congenital ptosis (ICP) and identify the genetic variants related to the condition. METHODS: Sixty-five unrelated patients with ICP were enrolled. Comprehensive clinical examinations, whole exome sequencing (WES), and Sanger…
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Therapeutic approaches to diabetic macular edema assessed using optical coherence tomography and optical coherence tomography angiography
Overt and harmful diabetes mellitus (DM) has detrimental effects on individuals and, by extension, the community. Among the microvascular DM complications is diabetic retinopathy (DR). DR may cause irreversible vision deterioration in cases of poor blood glucose regulation. Changes in vascular…
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Association between asthma and myopia: the NHANES database and Mendelian randomization analysis
AIM: To comprehensively assess the relationship between asthma and myopia based on the National Health and Nutrition Examination Survey (NHANES) database combined with Mendelian randomization (MR). METHODS: Initially, 20 497 subjects from the complete questionnaire cycle in the NHANES database from…
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Comparison of tear film quantity parameters between keratoconus and normal eyes
AIM: To compare the tear film quantity and stability parameters in keratoconus (KCN) and normal eyes using test breakup time (TBUT), noninvasive TBUT (NITBUT), and Schirmer test. METHODS: All participants (n=166), including patients with KCN and age-matched healthy individuals with normal corneas…
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Total score of the computer vision syndrome questionnaire predicts refractive errors and binocular vision anomalies
AIM: To evaluate the efficacy of the total computer vision syndrome questionnaire (CVS-Q) score as a predictive tool for identifying individuals with symptomatic binocular vision anomalies and refractive errors. METHODS: A total of 141 healthy computer users underwent comprehensive clinical visual…
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Clinical features and prognosis of orbital inflammatory myofibroblastic tumor
AIM: To investigate the clinical features and prognosis of patients with orbital inflammatory myofibroblastic tumor (IMT). METHODS: This retrospective study collected clinical data from 22 patients diagnosed with orbital IMT based on histopathological examination. The patients were followed up to…
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Flap amputation for severe epithelial ingrowth post-LASIK: a case report
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Intraocular inflammation after intravitreal injection of faricimab–a case series including one case of bilateral choroidal involvement
AIM: To report and analyze cases of sterile intraocular inflammation (IOI) following intravitreal faricimab injections in patients treated for neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME). METHODS: This double-center case series included nine eyes of six…
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Subretinal fluid in rhegmatogenous retinal detachment: potential biomarkers and therapeutic targets for proliferative vitreoretinopathy
Rhegmatogenous retinal detachment (RRD) is a serious ocular condition marked by the separation of the neuroretina from the retinal pigment epithelium (RPE). The pathogenesis of RRD involves intricate molecular and cellular mechanisms, including inflammation, cell migration, and the activation of…
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