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Journal of Traditional and Complementary Medicine
Scopus
ISSN 2225-4110 · Elsevier · 875 articles in the index
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Journal Article
Impact of traditional Korean medicine on suicide prevention in depression: A nationwide 10-year follow-up study
Background and aim: South Korea has the highest suicide rate among Organization for Economic Cooperation and Development countries, with major depressive disorder being a key predictor of suicide risk. Given the country's unique dual medical system integrating Western medicine and traditional…
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Journal Article
Pterostilbene-mediated microbiota shifts: Implications and opportunities
Pterostilbene, a natural stilbene compound present in blueberries and several medicinal plants, has been increasingly studied for its ability to influence gut microbiota composition across different disease contexts. In a variety of animal and cell-based models, researchers have observed notable…
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Journal Article
Effects of acupuncture at ST-36 (Zusanli) on pain and associated sleep disturbance
Chronic pain significantly disrupts sleep, leading to a vicious cycle that negatively impacts well-being. Pharmacological treatments for pain and sleep disorders often have adverse effects, highlighting the need for alternative therapies. This study investigates the impact of acupuncture at ST-36…
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Journal Article
Anti-inflammatory and polarization-modulating effects of Houttuynia cordata in LPS-stimulated RAW264.7 macrophages
Background and aim: Inflammation is a fundamental component of the immune response in host defense against pathogens and during tissue repair. Houttuynia cordata (HC), a herbaceous plant used in traditional Asian medicine, has significant anti-inflammatory and antimicrobial properties. However, the…
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Journal Article
Zhoushi Qiling decoction inhibits neuregulin 1 secreted from cancer-associated fibroblasts to ameliorate enzalutamide resistance in prostate cancer
Background and aim: Zhoushi Qiling decoction (ZQD) has emerged as a promising therapeutic agent for improving outcomes in prostate cancer treatment. This study aimed to evaluate the efficacy of ZQD on enzalutamide-resistant prostate cancer cells and to elucidates the underlying mechanisms…
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Journal Article
Qiangjing Tablets modulate oxidative stress and endoplasmic reticulum stress through the PI3K/Akt/NRF-2 signaling axis and regulate gut microbiota in ornidazole-induced asthenozoospermia rats
Background and aim: Asthenozoospermia (AZS) is a vital factor that causes male infertility. Qiangjing Tablets (QJT) is a Chinese medicine preparation that has good effects on improving kidney function and sperm motility. Although the effect of QJT on the AZS has been confirmed, its mechanism has…
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Journal Article
Dahuang Zhechong pill alleviates pulmonary fibrosis by inhibiting apoptosis and epithelial-mesenchymal transition of type II alveolar epithelial cells in vitro and in vivo
Background and aim: Idiopathic pulmonary fibrosis (IPF) is a lung disorder with an increasing incidence and poor prognosis. This study aimed to explore the effect of Dahuang Zhechong pill (DHZCP) in pulmonary fibrosis and its underlying mechanisms. Experimental procedure: We assessed the effect of…
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Journal Article
Electroacupuncture enhances the effects of escitalopram oxalate on glucocorticoid-inducible genes, inflammation and neurotrophin in depressed patients
Background and aim: Evidence proved that electroacupuncture (EA) combined with antidepressants can improve the antidepressant effectiveness for depressed patients. However, the clinical mechanisms of EA remain unclear. This study aimed to observe the mechanism of EA as an adjunct therapy to…
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Journal Article
Bushen Huoxue Recipe enhances the immune microenvironment at the maternal-fetal interface via the Hippo signaling pathway in mice with recurrent spontaneous abortion
Background and aim: Bushen Huoxue Recipe (BSHXR) has been proved clinical efficacy in treating recurrent spontaneous abortion (RSA), but the underlying mechanisms remain unknown. This study aimed to investigate the mechanism of BSHXR in the immune microenvironment of RSA. Experimental procedure…
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Journal Article
Integration proteomics analysis to identify AMPK as key target pathways of TCM formula for high fat diet induced obesity in mice
Background: Livsooth Authentic Herbal Formula (LAH) is a novel Chinese herbal medicine that has been previously shown to prevent non-alcoholic fatty liver disease (NAFLD). However, its efficacy in treating obesity and its underlying mechanisms remain unclear. This study uniquely investigates the…
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Journal Article
A double-blinded randomized clinical trial: Topical Sahasthara extract versus diclofenac for treating primary knee osteoarthritis using microemulsions as a topical delivery system
Background and aim: Sahasthara (SHT), a traditional Thai herbal remedy used for anti-inflammatory and musculoskeletal disorders, lacks clinical evaluation as a topical formulation employing microemulsion (ME) technology. This study aimed to assess the efficacy and safety of a Sahasthara…
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Journal Article
Damage-induced muscle regeneration after exercise in humans: Modulatory effects of ginsenoside Rg1
Exercise-induced focal sarcolemmal disruption in susceptible myofibers results in bone marrow cell infiltration and reduced cellular senescence in skeletal muscle, followed by increases in muscle strength and mass. In contrast, removal of gravitational loading during spaceflight or prolonged bed…
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Journal Article
Gancao Nourishing-Yin decoction ameliorates endothelial inflammaging induced by serum from rheumatoid arthritis patients
Background and aim: Inhibiting inflammaging is key to preventing cardiovascular complications in rheumatoid arthritis (RA) patients. Gancao Nourishing-Yin decoction (GCNY), a Chinese herbal remedy, has shown anti-inflammatory and antioxidative effects. This study explores the efficacy and mechanism…
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Journal Article
Geniposide activates the transcription of Ndufs8 and enhances PD-L1 blockade for inhibiting growth of osteosarcoma
Geniposide, a key bioactive component of Gardenia jasminoides, is an iridoid glycoside known for its therapeutic potential in various diseases characterized by oxidative stress or inflammation, including atherosclerosis, brain disorders, and diabetes. However, its effects on osteosarcoma and the…
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Journal Article
A novel postbiotic from Lacticaseibacillus rhamnosus CRL1505 able to enhance the steady-state myelopoiesis
The myelopotentiating effect of postbiotics derived from the probiotic Lacticaseibacillus rhamnosus CRL1505, including the peptidoglycan (PG1505), and the cell wall (CW1505), was evaluated in cyclophosphamide (Cy)-immunosuppressed mice. Adult Swiss mice were orally treated with the CRL1505 strain…
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Journal Article
Inhibitory effect of standardized Kaempferia parviflora extract on sarcopenia by improving protein metabolism pathways in aged C57BL/6J mice
Background: Sarcopenia is a muscle disease typically characterized by an age-related loss of muscle mass and function, leading to the deterioration of health in older adults. The current study aimed to investigate the therapeutic potential of standardized Kaempferia parviflora extract (KPE) on…
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Journal Article
Combination therapy of shinbaro and celecoxib improves joint pain and cartilage degradation in an osteoarthritis mouse model
Osteoarthritis is characterized by cartilage degeneration and joint pain, and celecoxib is widely used to treat osteoarthritis, but it has the risk of side effects. We investigated the effect of Shinbaro, a herbal medicine, combined with celecoxib in osteoarthritis. In vitro, primary chondrocytes…
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Journal Article
Spatholobus suberectus Dunn inhibits breast cancer bone metastasis in vitro and in vivo
Background and aim: Breast cancer bone metastasis (BCBM) has a high incidence in clinical settings, resulting in decreased life expectancy and quality of life. Previous research has shown that Spatholobus suberectus Dunn inhibits breast cancer lung metastasis. However, no studies have examined its…
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Journal Article
Gan-Mai-Da-Zao-Tang attenuates age-induced skeletal muscle wasting and improves mitochondrial function in mice
Background and aim: Skeletal muscle is the largest organ of the human body. It affects body metabolism and cooperates with other organs to maintain various physiological functions. Gan-Mai-Da-Zao-Tang (甘麥大棗湯, gān mài dà zǎo tāng, GMDZ) is a traditional Chinese medicine consisting of licorice…
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Journal Article
Enhanced bone tissue regeneration via mesenchymal stem cells-laden Alginate/GelMa 3D-Bioprinted scaffold treated with Haplophyllum tuberculatum extract
Background and aim: Regeneration of critical-sized bone defects is challenging due to avascular necrosis, inflammation, and disrupted osteogenesis. This study explores the synergistic effects of Haplophyllum tuberculatum (HT) extract and mesenchymal stem cells (MSCs) in an Alg/GelMa 3D-bioprinted…