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BioImpacts
Scopus
ISSN 2228-5652 · Tabriz University of Medical Sciences · 619 artikel di indeks
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Artikel Jurnal Teks lengkap
Long non-coding RNA PURPL in cancer and cellular regulation: Mechanistic insights and therapeutic potential
Long non-coding RNAs (lncRNAs) constitute a large fraction of the mammalian transcriptome and are increasingly recognized as critical regulators of gene expression and cellular homeostasis. Dysregulation of lncRNAs has been strongly implicated in cancer initiation and progression. PURPL…
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Checkpoint inhibition and beyond: Precision immune engineering for the immune-privileged landscape of ocular malignancies
Ocular malignancies, particularly uveal and conjunctival melanoma, exemplify tumors that evolve within one of the body’s most immunologically constrained ecosystems, the eye’s immune-privileged microenvironment. The limited success of PD-1/PD-L1 and CTLA-4 blockade in these cancers underscores the…
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Exaggerating the risks of vaccination is a dangerous health threat
Vaccine hesitancy and opposition lacking empirical support represent significant threats to public health, particularly when amplified by public health officials. This commentary provides evidence-based refutation of such anti-vaccine arguments, including (i) the robust epidemiological data…
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Exosomes: Redefining intercellular communication and the future of translational medicine
Exosomes are promising extracellular vesicles for diagnostics, drug delivery, and regenerative medicine. While we have made significant strides in understanding exosomes biogenesis and cargo variability, the translation of exosome-based methods into clinical applications remains limited by…
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Pharmacists in modern primary care and management of diseases: an evidence-based perspective on emerging technologies
Modern healthcare demands warrant the reconceptualization of pharmaceutical practitioners as primary caregivers capable of addressing contemporary medical challenges. Their specialized knowledge in molecular therapeutics, computational medicine tools, and physiological surveillance technologies…
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Emerging advancements and expanding technological scope of education and practices in pharmacy and pharmaceutical sciences
Introduction: The pharmacy profession stands at a pivotal moment, as emerging scientific advancements and evolving healthcare demands require adept pharmacy practitioners and scientists. The integration of precision medicine, cellular and acellular regeneration, nano and bioengineering (e.g., 3D/4D…
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Celastrol overcomes 5-fluorouracil resistance in osteosarcoma cells through p53-mediated apoptotic pathway modulation and P-glycoprotein inhibition: A comprehensive mechanistic study
Introduction: Osteosarcoma, a prevalent malignant bone tumor in children and adolescents, is hindered by chemoresistance, particularly to 5-fluorouracil (5-FU), driven by mechanisms such as P-glycoprotein (P-gp) overexpression and altered p53 signaling. Celastrol, a triterpenoid, exhibits…
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Enhancing cisplatin chemosensitivity in gastric cancer through LINC00162 silencing: Modulation of the PI3K/AKT pathway and NANOG downregulation
Introduction: Chemotherapy drugs serve as one of the primary treatments for gastric cancer. However, challenges, including drug resistance and adverse side effects of the chemotherapy drugs like cisplatin, limit their efficacy. Long non-coding RNAs (lncRNAs) have been increasingly recognized as…
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Three-dimensional bioprinted hydrogels for the management of diabetic wounds: A review
Globally, the prevalence of diabetes mellitus (DM), a chronic metabolic disease, is at its peak. Type 2 diabetes (T2D) is more common worldwide, which raises the risk of ulcers and chronic healing, or non-healing wounds. Overall 15% to 20% of people with diabetes develop diabetic foot ulcers…
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Current advancements and future prospects in the biorefinery and hyper-production of astaxanthin from Haematococcus pluvialis
Astaxanthin (AXT) is a valuable xanthophyll carotenoid extensively utilized across the nutraceutical, pharmaceutical, cosmetic, and aquaculture industries. While this high-demand compound is produced both synthetically and biologically, natural AXT derived from the microalga Haematococcus lacustris…
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Integrin-linked kinase (ILK) in hematologic malignancies: Bridging molecular mechanisms to therapeutic innovation
Therapy resistance remains a formidable challenge in hematologic malignancies despite significant advances in targeted therapies. This comprehensive review examines integrin-linked kinase (ILK) as a critical molecular hub at the nexus of cell adhesion, signal transduction, and therapy resistance…
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The interplay between non-coding RNAs and Wnt signaling pathway in leukemia: A narrative review
Leukemias are heterogeneous hematologic malignancies that involve dysregulated proliferation and impaired differentiation of hematopoietic cells. The Wnt signaling pathway, which regulates hematopoietic stem cell self-renewal and lineage commitment, is dysregulated across leukemia subtypes…
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Enhanced anticancer efficacy of α-lipoic acid-loaded TPGS micelles: Synthesis, characterization, and evaluation in a 4T1 breast cancer model
Introduction: α-Lipoic acid (ALA) is a potent antioxidant with anticancer properties, but its clinical application is limited by poor water solubility and low bioavailability. Current nanocarrier systems for ALA delivery suffer from low encapsulation efficiency, rapid drug release kinetics, and…
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The emergence of advanced technologies in the pharmacy profession and the need for education: The case of point-of-care sensing systems and 3D printing of pharmaceuticals
Introduction: The pharmacy profession is undergoing significant transformation through the adoption of point-of-care testing (POCT) and three-dimensional (3D) printing of pharmaceuticals. These technologies offer enhanced diagnostic accuracy, faster therapeutic interventions, and the potential for…
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Low-level lasers can improve spermatogenesis in infertile mice by targeting molecular pathways
Introduction: Infertility affects approximately 15% of couples worldwide, with male factors accounting for approximately half of the cases. Low-level laser therapy (LLLT) has been increasingly considered in modern medicine due to its high efficacy, ease of use, and lack of side effects. Evidence…
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Moroccan virgin olive oil triterpenes: HPLC-DAD-ELSD profiling and computational investigation of anti-diabetic potential
Introduction: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia due to impaired insulin secretion or resistance. Conventional treatments like acarbose, miglitol, and voglibose inhibit carbohydrate-digesting enzymes but often cause adverse effects and have…
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Synergistic effects of phytochemical cocktail and aerobic exercise on mRNA and lncRNA networks modulating bone turnover in hypothyroid mice
Introduction: Metabolic bone disease (MBD) is a multifactorial condition that leads to microarchitectural and bone mass disturbance. The association and mechanisms between MBD and hypothyroidism are not comprehensively elucidated. Moreover, long non-coding RNAs (lncRNAs), as critical regulators in…
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Hybrid deep learning models for text-based identification of gene-disease associations
Introduction: Identifying gene-disease associations is crucial for advancing medical research and improving clinical outcomes. Nevertheless, the rapid expansion of biomedical literature poses significant obstacles to extracting meaningful relationships from extensive text collections. Methods: This…
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Biomarkers for colorectal cancer detection: An insight into colorectal cancer and FDA-approved biomarkers
Colorectal cancer (CRC) constitutes a significant global health challenge, accounting for a considerable proportion of cancer cases and associated mortality. Projections indicate a potential increase in new cases by 2040, attributed to demographic factors such as aging and population growth…