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Basic & Clinical Cancer Research
ISSN 2228-6527 · Tehran University of Medical Sciences · 330 articles in the index
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Journal Article
MRI Features of Malignant Transformation of Pelvic Endometriosis: A Systematic Review
Background: Endometriosis is a benign gynecologic condition that is estrogen-dependent. Malignant transformation is one of the complications of endometriosis; it can affect the woman's ovarian and extra-ovarian regions. Diagnosing endometriosis-associated cancers has an essential role in treatment…
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Journal Article
A Life-Course Lens for Etiology and Prevention of Gastric Cancer
Gastric cancer (GC) remains a significant public health challenge in many low- and middle-income countries, particularly Iran. Despite advances in medical care and public health infrastructure, GC incidence among older adults continues to be alarmingly high. While much research has focused on adult…
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Journal Article
Unaltered mRNA Levels of EGFR and PIK3CA in Head and Neck Squamous Cell Carcinoma
Background: Since its identification, the Epidermal Growth Factor Receptor (EGFR) signaling pathway through PIK3CA, has been known to be involved in the pathogenesis of several solid tumors especially Head and Neck Squamous Cell Carcinoma (HNSCC). Impaired signal transduction through EGFR-PIK3CA…
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Journal Article
Molecular Evaluation of TNF-α-308 and TNF-α-238 Polymorphisms and their Association with HPV Genotypes in Cervical Lesions
Abstract Background: Cervical cancer is a multi-stage disease that is contaminated by a DNA virus and is involved in one or more stages in the pathogenesis process. In addition to human papillomaviruses (HPV), the tumor necrosis factor-α gene (TNF-α) is considered a major intermediate mediator of…
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Journal Article
Five-year survival and prognostic factors among oral cavity squamous cell carcinoma patients: Analyses of data from the Cancer Institute of Iran
Background: We conducted a historical cohort study and studied the survival rate and prognostic factors of oral cavity squamous cell carcinoma among patients admitted at the Cancer Institute of Iran. Methods: We recruited 352 patients who were referred to the Cancer Institute hospital in 2004-2011…
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Journal Article
Her-2neu Expression In Endometrial Carcinoma Patients- A Preliminary Study from Western India
Background: - Her-2neu is a gene from the epidermal growth factor receptor family. It is known to regulate cell growth. Her-2neu overexpression or amplification is more common in type2 endometrial cancer than in type1. Overexpression of Her-2neu has been associated with poor prognosis. This study…
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Journal Article
Identification of Lung Cancer metabolomics profile and molecular interactions using bioinformatic methods
Lung cancer represents a significant public health challenge, representing a considerable contributor to cancer-related mortality. However, the current diagnostic methods for early detection of lung cancer are constrained by various limitations, such as inadequate clinical resources and effective…
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Journal Article
First global Report of Alkaloids Tubotaiwine and Vinervine in Vinca herbacea: Potential Pharmacological Applications
Vinca herbacea Waldst. & Kit., a perennial species of the Apocynaceae family, is distributed across temperate regions of Asia and Europe but occurs only in limited areas of northern Iran, particularly along the Alborz Mountains. Members of the Apocynaceae are known for producing pharmacologically…
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Journal Article
Proton beam physical processes for improving cancer therapy using a water phantom
The aim of this work is a description of quantitatively and qualitatively physical processes for proton therapy when a proton pencil beam passes through a water phantom. Therefore, at first, we determine the absorbed dose with both Maple programming and Geant4 simulation in the suggested water…
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Journal Article
Monosodium Glutamate’s Dose-Dependent Effects on Prostate Cancer Markers and Sperm Quality
This study investigates the effects of monosodium glutamate (MSG) on serum markers of prostate cancer, and semen quality, in male Wistar rats. The rats were administered varying doses of MSG (15mg, 50mg, 100mg, 500mg, and 1000mg/kg body weight) for 28 days. Our results showed that 15mg/kg MSG…
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Journal Article
The Evolution of Population-Based Cancer Registries in Iran: A 70-Year Journey
data on cancer incidence, prevalence, and mortality. This paper reviews the development, current status, and challenges of the Population-Based Cancer Registry (PBCR) program in Iran. Since the 1950s, Iran has made significant efforts to establish systematic cancer registration, culminating in the…
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Journal Article
Intratumoural Microbiota: Roles in Cancer Development, Prognosis, and Therapy
Breakthroughs in sequencing technologies have overturned the notion that tumor tissues are sterile, revealing that a wide array of bacteria, fungi, and viruses—collectively known as the intratumoral microbiota—inhabit tumors across diverse cancer types. These microorganisms, which can colonize…
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Journal Article
Case report: Mesenteric Fibromatosis
A 28-year-old patient reported having a lump in the right lower abdominal and pelvic area for the last 21 days along with pain, anorexia, fever, and nausea. After a thorough investigation, an AP scanogram of the patient showed a clearly defined lump in this area. Histopathological examination…
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Journal Article
Association between Childhood and Adulthood Risk Factors and Risk of Gastric Cancer: A Hospital-Based Case-Control Study in Iran
Background: Gastric cancer (GC) is the most common cancer among Iranian men. This study aimed to investigate the association between early and late lifestyle risk factors and GC among the Iranian population. Methods: A hospital-based case-control study recruited gastric cancer (GC) patients from…
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Journal Article
Sensitivity of Self-reported Opium Use in Cancer Patients: Implications for conducting epidemiological studies
Background: Underreporting bias related to opium use is a significant methodological issue that can threaten the results of epidemiologic studies, particularly when opium use is the exposure of interest. In our current study, we aimed to measure the sensitivity of opium use. among cancer patients…
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Journal Article
Clinicopathological Spectrum of Indian Adolescent and Young Adults (AYA) Gynecological Tumors: A Retrospective Analysis
Background: Cancers in adolescents and young adults (AYA) represents a bridge between childhood and elderly incidence curves of cancers demanding tailored approaches and management of their distinct presentations. The literature on Indian gynecological cancer patients aged 15 to 39 years is…
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Journal Article
A review of the role of enterotoxigenic Bacteroides fragilis in the development of colorectal cancer
Enterotoxigenic Bacteroides fragilis (ETBF) plays a significant role in the development and progression of colorectal cancer (CRC) through the production of Bacteroides fragilis toxin (BFT). This toxin activates Wnt, NF-κB, and STAT3 signaling pathways, leading to chronic inflammation, DNA damage…
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Journal Article
Ethics and Cancer
The ethical challenges in cancer care are complex and varied. Delving deeper into the multifaceted issues that healthcare professionals and patients face is necessary. These challenges are deeply intertwined, requiring a nuanced understanding and approach
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Journal Article
Bioinformatics screening of therapeutic targets in chemoresistance human colon cancer HCT8 cell line
Background: Chemoresistance is still one of the main challenges in treatment of cancers, including colon adenocarcinoma (COAD). COAD is a common cancer with a high mortality. The goal of this study was to identify and evaluate the differentially expressed mRNAs (DEmRNAs) associated with both…
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Journal Article
Epigenetic mechanisms associated with progression, prognosis, and new treatment strategies for metastatic cervical squamous cell carcinoma
Background: In the 21st century, the main cause of death in both sexes worldwide are cardiovascular diseases, in second place are neoplasms. In the case of women, the fourth cause of mortality is breast cancer despite the screening. Objective: Understanding the epigenetic mechanisms associated with…