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Avicenna Journal of Phytomedicine
Scopus
ISSN 2228-7930 · Mashhad University of Medical Sciences · 795 artikel di indeks
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Synergistic inhibitory effects of Trifolium pratense L. extract and doxorubicin on 4T1 tumor-bearing mice are mediated via targeting the Wnt/β-catenin pathway and reversal of epithelial-mesenchymal transition
Objective: Triple-negative breast cancer (TNBC) presents significant therapeutic challenges. This study investigates the combination effects of Trifolium pratense L. (red clover) and doxorubicin (DOX) on the Wnt/β-catenin signaling pathway, epithelial-mesenchymal transition (EMT) and apoptosis in…
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Protective effects of Elaeagnus angustifolia L. fruit extract on CCl4-induced oxidative stress and inflammation in rats liver
Objective: Hepatic cells face oxidative stress-induced damage, but plant antioxidants may offer protection. This study aimed to assess Elaeagnus angustifolia L. fruit extract's potential in shielding rat livers from CCl4 damage.Materials and Methods: 30 Male Wistar rats were randomly divided into…
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Effect of a Persian medicine formula, Glasthma, on lung function and intestinal permeability in Asthma: A triple-blind randomized controlled trial
Objective: This study aimed to evaluate Glasthma, a Persian medicine herbal formulation for its efficacy and safety in managing asthma symptoms and modulating intestinal permeability.Materials and Methods: Forty randomly assigned asthma patients received Glasthma syrup (n=20) or a placebo (n=20)…
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Green tea polyphenols, epicatechin gallate and epigallocatechin gallate, alleviated aberrant metabolic changes caused by olanzapine in rats
Objective: Olanzapine, a well-known antipsychotic drug, causes considerable weight gain and metabolic abnormalities in patients. Green tea (Camellia sinensis) has anti-obesity, antihypertensive, antihyperlipidemic, and anti-diabetes effects. The aim of this study was to investigate the potential…
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Phenolic screening, antioxidant activity and diuretic effect of Moroccan Pinus pinaster Bark extract
Objective: This study aims to evaluate the chemical composition antioxidant activity, and diuretic effects of Moroccan Pinus pinaster bark ethanolic extract (PPBE).Materials and Methods: The phytochemical composition of PPBE was assessed using HPLC-DAD. Total polyphenols and flavonoids were…
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Green synthesis of selenium nanoparticles using Cordia myxa extract and assessment of their cytotoxic and antioxidant properties
Objective: This research aimed to explore the cytotoxic, apoptotic, and antioxidant effects of selenium nanoparticles (Se-NPs) produced by Cordia myxa (C. myxa) aqueous extract via a green reduction method.Materials and Methods: To synthesize Se-NPs, Na2SeO3 and C. myxa plant extract were used and…
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Impact of strawberry consumption on blood pressure in adults: GRADE-assessed systematic review and dose-response meta-analysis of data from randomized controlled trials
Objective: This systematic review and meta-analysis aimed to assess the impact of strawberry (Fragaria x ananassa) consumption on systolic (SBP) and diastolic blood pressure (DBP).Materials and Methods: PubMed, Web of Science, Scopus, and Google Scholar were searched to find relevant randomized…
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Syringic acid attenuates sodium arsenite-induced hepatotoxicity and diabetes in mice via suppression of oxidative stress/inflammation/apoptosis pathways
Objective: Chronic exposure to arsenic increases the risk of type 2 diabetes. Syringic acid (SYRA) has anti-inflammatory and antidiabetic properties. The aim of this study was to investigate the effects of SYRA on sodium arsenite-induced hepatotoxicity and diabetes in mice.Materials and Methods…
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Thymoquinone alleviates the adverse effects of cyclophosphamide on oogenesis and in vitro fertilization (IVF) in NMRI mice
Objective: Patients undergoing treatment with antineoplastic drugs face numerous challenges. This study investigates the effects of thymoquinone (Tq) in NMRI mice treated with cyclophosphamide (Cph), aiming to enhance patients' optimism for the future by redirecting their focus towards achieving a…
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Carvacrol alleviates the proconvulsive effects of lipopolysaccharide (LPS) and reduces the gene expression of proinflammatory cytokines interleukin-1 and tumor necrosis factor-α
Objective: Carvacrol has anti-inflammatory effects. According to the links between inflammatory processes and seizures, this study was designed to investigate the potential effect of carvacrol in reducing seizure severity and involvement of hippocampal pro- and anti-inflammatory cytokines.Materials…
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Inhibition of mast cell activation via MRGPRX2 receptor by Curcuma mangga and Sonchus arvensis water suspensions: An in vitro study
Objective: Traditional medicine is often used to relief pain, but its use is frequently not supported by appropriate scientific information. This study aims to investigate the histamine release suppression of Sonchus arvensis (SA) and Curcuma mangga (CM).Materials and Methods: Rat peritoneal mast…
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Comparison the effect of Asvard capsule and omeprazole in treatment and recurrence of non-cardiac chest pain related to gastroesophageal reflux disease in adults: A controlled double blind clinical trial
Objective: Considering the burden of non-cardiac chest pain (NCCP) on emergency departments and the difficulties related to the treatment of the disorder, the present study aims to investigate the effect of Asvard capsule (containing Myrtus communis and Rosa damascena) compared to routine treatment…
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Green tea as a cosmetic agent for skin aging: A scoping review
Objective: Tea is known to have antioxidant and anti-inflammatory properties. Also, skin care products often contain antioxidant compounds that help protect the skin from free radicals that cause premature aging. In this study, we investigated the antioxidant and anti-aging effects of whole green…
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F2 peptide fraction of Androctonus crassicauda scorpion venom: Inducing M2 to M1 macrophage polarization and inhibiting colon carcinoma cell proliferation and migration
Objective: Colorectal cancer (CRC) is among the deadliest malignancies, often diagnosed at advanced stages, limiting treatment efficacy and necessitating alternative therapeutic approaches. Scorpion venom has emerged as a promising source of bioactive compounds for cancer therapy. This study…
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Anti-oxidant and anti-apoptotic effects of gamma-oryzanol on male reproductive function in chronic restraint stress in rats
Objective: This study investigates the effects of GO on depressive behaviors and reproductive parameters in rats exposed to CRS.Materials and Methods: Rats were divided into three groups: sham, CRS-control, and CRS-GO. Behavioral assessments using the SPT and measurements of body and testes weights…
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Atorvastatin and flaxseed dietary treatments improve dyslipidemia and liver injuries in a diet-induced rat model of non-alcoholic fatty liver disease
Objective: Non-alcoholic fatty liver disease (NAFLD) as the most common chronic liver disease is associated with metabolic disorders including dysregulated lipid and glucose metabolism. There is no approved drug treatment for NAFLD; thus, new therapies are needed. We studied the antidyslipidemic…
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Evaluating the effect of crocin on contrast-induced nephropathy in rats
Objective: Contrast-induced nephropathy (CIN) raises the risk of renal injury, but crocin, a saffron component, may improve kidney function. This study investigated crocin's protective effects against CIN in rats.Materials and Methods: Male Wistar rats were divided into eight groups: Sham, Control…
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Protective role of zeaxanthin on acrylamide-induced neurotoxicity in Wistar rats
Objective: The Maillard reaction generates acrylamide (ACR), a toxic compound commonly found in laboratory and industrial settings. ACR exposure, both short-term and long-term, can damage various organs, notably the central nervous system, through oxidative stress, inflammation, and apoptosis. This…
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Antioxidant effects and protective potential of fruit extracts of Detarium microcarpum against arsenic trioxide-induced human lymphocytes DNA oxidative damages
Objective: The integrity of the DNA is continously menaced by the harmful genotoxic compounds. The endogenous system responsible for preserving the DNA integrity, often fails following a massive influx of these genotoxic compounds. Reseaches on exogenous bioactive compounds from fruits and…
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Artikel Jurnal Teks lengkap
The protective properties of resveratrol against glycerol-induced acute kidney injury in rats
Objective: After rhabdomyolysis, muscle tissue releases substances such as myoglobin, creatine kinase, and electrolytes into the bloodstream, potentially leading to acute kidney injury (AKI). Resveratrol (RSV) is a polyphenol compound with anti-inflammatory and antioxidant effects and it is found…