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Journal of Advanced Pharmaceutical Technology & Research
Scopus
ISSN 2231-4040 · Wolters Kluwer Medknow Publications · 941 artikel di indeks
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Artikel Jurnal
Nephroprotective effect of lercanidipine against gentamicin-induced kidney damage
Gentamicin, an aminoglycoside antibiotic, induces nephrotoxicity mainly through oxidative stress. This study evaluated the nephroprotective potential of lercanidipine, a calcium-channel blocker, against gentamicin-induced renal injury in rats. Adult Sprague–Dawley rats were randomly divided into…
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Metformin ameliorates pentylenetetrazol-induced seizures in mice by modulating peroxisome proliferator-activated receptor gamma, nuclear factor-kappa B, matrix metalloproteinase 2, and caspase-3
Owing to less efficiency of currently available antiepileptic medications, research is continuing toward the most effective solution. It was observed that the antidiabetic drug metformin (MET) is getting more attention in the modern world due to its good anti-inflammatory and neuroprotective…
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Antioxidant activities and toxicity of dichloromethane and n-hexane extracts of Annona squamosa L. leaves
Annona squamosa contains some secondary metabolites and has significant biological activities, including antioxidant. The toxicity of n-hexane and dichloromethane (DCM) extracts from A. squamosa leaves was evaluated using the Brine Shrimp Lethality Test, while their antioxidant activity was…
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Artikel Jurnal
Exploring the bioactive compounds and molecular mechanisms of onion (Allium cepa L.) peels against prostate cancer through molecular docking and network pharmacology
Studies have shown onion peels to have potential anticancer effects on prostate cancer (PCa) development but with limited understanding of the underlying mechanisms. Therefore, this study aimed to explore potential bioactive compounds, molecular mechanisms, target proteins, and synergistic…
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Artikel Jurnal
Bioactivity assessment of methanolic extract of Rhododendron cowanianum: An endemic species of Nepal
Rhododendron cowanianum is an endemic shrub of Nepal. This study investigated the phytochemical profile along with the antioxidant, antimicrobial, and cytotoxic properties of its methanolic extract. Qualitative phytochemical screening showed the presence of alkaloids, phenols, flavonoids, tannins…
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Antioxidant and nitric oxide production inhibitory activities of Liriope platyphylla and Asparagus cochinchinensis (Liliaceae) extracts
Liriope platyphylla and Asparagus cochinchinensis have been utilized as adjunctive therapies for disorders involving immune dysfunction in Korea. This study investigated the antioxidant and nitric oxide (NO) production inhibitory activities in different extracts of the two plants. The antioxidant…
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Artikel Jurnal
Protective effects of the ethanolic extract from the Benjakul remedy against oxidative stress and inflammation
Oxidative stress and inflammation contribute to liver damage from xenobiotics, leading to chronic diseases. The ethanolic extract of the Benjakul remedy (BJE), a traditional Thai medicine, is recognized for its potential antioxidant and anti-inflammatory effects, though scientific validation is…
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The impact of Saurauia vulcani Korth. on hepatic CD4+ T-cell profiles and serum interleukin-2 levels in rats induced by Salmonella typhimurium
CD4+ T-cells and interleukin-2 (IL-2) are key regulators of the immune response, particularly during Salmonella infections. Saurauia vulcani Korth., commonly referred to as pirdot, is a traditional medicinal plant rich in flavonoids known for their anti-inflammatory effects. This study aimed to…
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Chemometric classification of red ginger (Zingiber officinale var. Rubrum) oleoresin from different regions using Fourier-transform infrared-ATR spectroscopy
Red ginger contains valuable oleoresins, primarily gengerols, shogaol, and zingerone. However, its chemical profile can vary by geographic origin. This study aimed to classify the red ginger samples from different regions based on their chemical characteristics. Ethanol extracts of red ginger were…
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Artikel Jurnal
Effect of sperm cryopreservation and preparation before freezing–thawing process: A study of DNA fragmentation and ultrastructure
Male fertility preservation can be achieved through assisted reproductive technology, in which sperm cryopreservation plays an essential role. However, the freezing–thawing process induces cellular stress, primarily through intracellular ice crystal formation, which damages membranes, organelles…
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Evaluation of the therapeutic effects of 10% bangun-bangun (Coleus amboinicus) leaf gel on second-degree burn healing in Wistar rats
Burns are traumatic injuries that compromise the skin’s natural barrier, initiating a complex process of inflammation, proliferation, and tissue maturation. Second-degree burns, in particular, cause extensive tissue damage and require effective treatments that both accelerate healing and reduce…
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Proteomic profiling and regenerative potential of bovine placental extract in wound healing models
The placenta is rich in proteins and metabolites that modulate repair processes. Bovine placental extract (BPE) offers a practical alternative to human-derived materials for regenerative applications. The study aimed to characterize the proteomic composition of BPE and evaluate its regenerative…
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Antifungal activities and in silico prediction of Moringa oleifera Lam. fractions of leaves against Candida albicans
There is an escalating demand to identify novel bioactive compounds from medicinal plants due to the increasing number of antifungal-resistant pathogenic microorganisms. This study aimed to evaluate the antifungal activities of Moringa oleifera Lam. (MoLm.) leaves and the potential of its chemical…
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Comparison of yogurt and ultra-high-temperature milk on serum osteocalcin and calcium levels in rats
Dairy products may influence bone metabolism through calcium bioavailability and modulation of gut microbiota. This study compared the effects of yogurt and ultra-high-temperature (UHT) milk on serum osteocalcin and calcium levels in rats. Twenty-four male Wistar rats (Rattus norvegicus) were…
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Characteristics of natural sunscreen cream-containing lignosulfonate, olive leaf extract, and propolis
A natural O/W sunscreen based on lignosulfonate, olive leaf extract, and propolis was developed. Formulations were evaluated for physicochemical properties, antioxidant and antibacterial activities, and sun protection factor (SPF). Results showed physical stability over 28 days with particle sizes…
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Combined inulin, glucomannan, and medium-chain triglyceride modulate metabolic and inflammatory responses in chemotherapy-treated colorectal cancer cells
Colorectal cancer (CRC) remains a global health challenge. The efficacy of 5-fluorouracil (5-FU) is frequently limited by chemoresistance, inflammation, and compensatory pro-angiogenic signaling. Prebiotic fibers and metabolically active lipids have been shown to modulate immune-metabolic pathways…
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Artikel Jurnal
Ameliorative effects of onion anthocyanin extract on spermatogenic function in cimetidine-induced testicular toxicity in male mice
Cimetidine, an H2 receptor antagonist with anti-androgenic disrupts testicular structure and spermatogenesis. Anthocyanins in red onion (Allium cepa) have good antioxidant and cytoprotective action. This study compared the protective ability of onion-derived anthocyanin extract on the…