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Frontiers in Cellular and Infection Microbiology
Scopus
ISSN 2235-2988 · Frontiers Media S.A. · 12.562 artikel di indeks
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Artikel Jurnal
Biofilm-related characteristics of Candida parapsilosis in postoperative ocular infections
ObjectiveThe research aims to elucidate the pathogenic mechanisms of Candida parapsilosis infection after keratoplasty and provide evidence-based guidance for the clinical management of Candida infections in ophthalmic practice.MethodBiofilms were cultured from 45 strains of Candida. The total…
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Artikel Jurnal
Harnessing the gut microbiome to combat tuberculosis: a technological and clinical review
Tuberculosis (TB), especially multidrug-resistant and extensively drug-resistant strains, remains a severe global health threat. Advances in high-throughput sequencing, omics technologies and artificial intelligence have revealed the critical involvement of the gut microbiome (GM) in TB…
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From virtual screening to animal models: chlorhexidine and indinavir as promising anti-Zika drug candidates
IntroductionZika virus (ZIKV) infection is associated with severe neurological complications, but no clinically approved antiviral therapies exist, leaving management reliant on symptomatic support. The essential NS2B/NS3 protease represents a promising drug target for ZIKV.MethodsWe performed…
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Carcinogen metabolism and bladder cancer: role of gut microbiota in disease and prevention
Bladder cancer remains a significant global health concern, with environmental carcinogen exposure—particularly from tobacco-derived compounds such as aromatic amines, polycyclic aromatic hydrocarbons (PAHs), and nitrosamines—recognized as a primary etiological factor. These carcinogens undergo…
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A broad-spectrum SARS-CoV-2 RBD vaccine with selected high-impact mutations and novel adjuvant induces durable T cell response and broad protection in mice
IntroductionThe emergence of new SARS-CoV-2 variants with immune evasion capabilities underscores the importance of developing a broad-spectrum and effective vaccine. The receptor binding domain (RBD) of the Spike protein has been widely utilized in vaccine due to its high immunogenicity. However…
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Artikel Jurnal
Gut microbiota as a key regulator in endometriosis: mechanisms, therapeutic opportunities, and future perspectives
Endometriosis (EMs), a common and frequently occurring gynecological disease, is a major cause of chronic pelvic pain and infertility in women. Its pathogenesis remains unclear to date, and it is characterized by high invasiveness and recurrence tendency. Although the specific pathogenesis of EMs…
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Artikel Jurnal
Clinical characteristics and prognostic impact of Burkholderia cepacia complex colonization and infection in patients with hematologic malignancies
ObjectiveIn recent years, there has been an increasing number of reports on infections caused by the Burkholderia cepacia complex (Bcc). However, the clinical characteristics and prognosis of Bcc infections in patients with hematological malignancies remain unreported. This study aimed to delineate…
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Zika virus infection disturbs development of human muscle progenitor cells
Zika virus (ZIKV) infection has emerged as a global public health emergency due to its expansion capacity and ability to cause neurological and congenital diseases. Muscle cells are targets for ZIKV, and myalgia and muscle disorders are frequently related symptoms during infection. We have…
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Artikel Jurnal
Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells
IntroductionPorphyromonas gingivalis (Pg), a keystone periodontal pathogen, is a known risk factor for atherosclerosis and cardiovascular disease. Lysine lactylation (Kla) is an emerging post-translational modification (PTM) that bridges cellular metabolism and epigenetic regulation. However, the…
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Bovine leukemia virus: an emerging concern for zoonotic cross-species transmission
Bovine leukemia virus (BLV) is a retrovirus that causes leukemia-like disorders in cattle and sheep, as well as inflammatory conditions and reduced milk production in dairy cows, leading to substantial economic losses in the global cattle industry. BLV infection is widely prevalent among cattle…
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Encapsulated probiotics as antimicrobial agents: mechanisms and delivery strategies against multidrug-resistant pathogens
The rapid escalation of antimicrobial resistance (AMR) has rendered many conventional antibiotics ineffective, emphasizing the need for alternative therapeutic approaches. Probiotics have emerged as promising biotherapeutic agents capable of inhibiting multidrug-resistant (MDR) pathogens through…
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Artikel Jurnal
Microbiota-driven therapeutic efficacy of Hyperoside in ulcerative colitis and associated anxiety
BackgroundUlcerative colitis (UC) is subtype of inflammatory bowel disease that is frequently comorbid with anxiety disorders. However, effective dual-targeting therapies are still lacking. Hyperoside (HYP), a natural flavonoid, exhibits anti-inflammatory and neuroprotective properties, yet its…
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AMPylation: key roles in biological regulation across prokaryotes and eukaryotes
AMPylation, as a crucial post-translational modification, is widely present in both prokaryotes and eukaryotes, playing a key role in regulating biological functions. The regulation of biological functions by AMPylation is a complex and diverse process. In prokaryotes, AMPylation plays a role in…
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Mechanistic pathways predictive modeling and translational interventions for radiation enteritis in cervical cancer radiotherapy
Radiation enteritis remains a major dose-limiting toxicity in cervical cancer radiotherapy, significantly impairing treatment continuity, long-term gastrointestinal function, and patient quality of life. Despite advances in radiation techniques, the biological heterogeneity of intestinal…
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Hepatitis B virus RNA and hepatitis B surface antigen kinetics predict treatment outcomes in children with chronic hepatitis B
BackgroundSerum hepatitis B virus (HBV) pregenomic RNA (pgRNA) predicts antiviral response in adults with chronic hepatitis B (CHB); however, its prognostic performance against conventional biomarkers in children remains underexplored. This study aimed to characterize the kinetics of pgRNA and…
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Implications of host sex on liver metabolism during Schistosoma mansoni Infection
Various studies suggest that host gender is a disease-determining factor in schistosomiasis. Men have a higher prevalence in endemic areas and show a greater degree of liver damage in chronic infection with Schistosoma mansoni. It is currently unclear whether this is only due to socioeconomic…
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Hypercapnic acidosis affects in vitro lung infection response in a pathogen-specific manner
BackgroundHypercapnic acidosis (HCA) is a hallmark of acute hypercapnic respiratory failure, often triggered by respiratory infections. Its role in lung injury remains controversial, with both protective and detrimental effects reported. However, the specific impact on pulmonary immune responses to…
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Artikel Jurnal
Neutrophil-to-lymphocyte ratios as easy-to-use biomarkers for the diagnosis of active tuberculosis in children and adolescents
BackgroundThe diagnosis of active tuberculosis (ATB) in children and adolescents is limited by non-specific symptoms, paucibacillary infection, and the low sensitivity of traditional tools. These limitations can lead to delayed treatment and increased complications.MethodsThis retrospective study…
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Glaesserella parasuis infection disrupts the gut–lung axis via microbiota dysbiosis and metabolic reprogramming leading to intestinal barrier impairment in piglets
BackgroundGlaesserella parasuis (G. parasuis), is a key respiratory pathogen responsible for Glässer's disease in pigs, characterized by polyserositis, arthritis, and pulmonary lesions. While it disrupts the respiratory microbiota, its impact on the gut-lung axis, a critical pathway for systemic…
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