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National Journal of Laboratory Medicine
ISSN 2277-8551 · JCDR Research and Publications Pvt. Ltd. · 951 artikel di indeks
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Evaluating Scoring Systems and Biomarkers for Disseminated Intravascular Coagulation in Critically Ill Patients: A Prospective Cohort Study
Introduction: Disseminated Intravascular Coagulation (DIC) is a critical haemostatic disorder marked by systemic activation of coagulation, leading to microvascular thrombosis, consumption of clotting factors, and bleeding. Multiple diagnostic criteria exist however, no universally accepted gold…
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Prognostic Significance of Bcl-2 and Ki-67 Expression in Gastric Carcinoma: A Cross-sectional Study at a Tertiary Care Centre in Chennai, Tamil Nadu, India
Introduction: Gastric cancer was at fifth place in both incidence and mortality worldwide in 2022. The B-cell lymphoma (Bcl-2) anti-apoptotic gene is aberrantly expressed in a sequential manner in the carcinogenesis of gastric cancer. Ki-67 is correlated well with poorer survival and high level of…
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Immunohistochemical Evaluation of BRAF V600E and HER2 Expression in Colorectal Carcinoma and Their Association with Clinicopathological Parameters: A Cross-sectional Study from a Tertiary Care Centre in Eastern India
Introduction: Colorectal Carcinoma (CRC) is the third most common cancer in the world according to Global Cancer Observatory (GLOBOCAN) statistics, 2022. CRC’s phenotypic and molecular comprehensive characterisation represents a key step, with diagnostic and prognostic value assessment of BRAF…
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Evaluation of Factor VIII Inhibitor Titre in Haemophilia A Patients: A Cross-sectional Study from a Tertiary Care Institute in Eastern India
Introduction: Haemophilia has a high disease burden in India and development of inhibitors/antibodies to the Factor VIII (FVIII) replacement therapy is a major problem leading to treatment failure, poor quality of life and high financial burden. Identifying risk factors associated with inhibitor…
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A Large Recurrent Proliferating Trichilemmal Tumour of Gluteal Region: A Case Report with Review of Literature
Proliferating Trichilemmal Tumour (PTT) is an uncommon, benign skin appendageal tumour with distinctive morphologic features. It most commonly presents as a well-circumscribed subcutaneous nodule, and its histological hallmark is the presence of trichilemmal keratinisation and squamoid cytological…
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A Review on Liability of Redundant Tests in Clinical Biochemistry Laboratory: A Threat to Quality Maintenance
Clinical biochemistry laboratories support various aspects of healthcare, including routine blood tests, specialised investigations, and blood analysis for critical care monitoring. From each of these units, various tests are ordered with no consequence in diagnosis or decision-making. The…
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Association of HbA1c with Oxidative Stress and Peripheral Neuropathy in Newly Diagnosed Type 2 Diabetes Mellitus Cases: A Cross-sectional Study
Introduction: Diabetic neuropathies are the most common, yet least understood and recognised long-term complications of diabetes. With rising Glycated Haemoglobins (HbA1c) levels, nerve conduction velocities slow and amplitudes decrease, indicating ongoing damage to the myelin sheaths and axonal…
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Clinicopathological Spectrum and Expression of Basal Markers CK5/6 and EGFR in Triple-Negative Breast Cancer: A Cross-sectional Study
Introduction: Triple-Negative Breast Cancer (TNBC) is a biologically diverse disease identified through Immunohistochemistry (IHC) and defined as the absence of Oestrogen Receptor (ER), Progesterone Receptor (PR), and Human Epidermal Growth Factor Receptor 2 (HER2) expression. This subtype is very…
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Congenital Pulmonary Airway Malformation, Stocker Type I: A Case Report
Congenital Pulmonary Airway Malformation (CPAM), formerly known as congenital Cystic Adenomatoid Malformation (CCAM), is a rare developmental dysplastic lesion of the foetal tracheobronchial tree and a rare cause of neonatal respiratory distress. Here, authors present a case of term, male newborn…
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Diagnostic Challenges in Rare Head and Neck Tumours: A Series of Five Cases
Meningiomas constitute a large group of tumours of the central nervous system with the prevalence of 24-30%. Extracranial localisation of meningioma is rare. By definition they are not associated with underlying meningioma of the neuraxis and extracranial extension of an intracranial tumour should…
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Immunohistochemical Expression of MutS Homolog 6 (MSH6) and Postmeiotic Segregation 2 (PMS2) and Their Association with Clinicopathological Features in Colorectal Carcinoma: A Cross-sectional Study
Introduction: Colorectal Carcinoma (CRC) is a gastrointestinal malignancy arising from colon or rectum. Adenocarcinoma is the most common type of CRC. It is one of the most commonly diagnosed cancer worldwide, ranking third only to lung cancer and female breast cancer. About 15% of CRC cases are…
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Evaluation of Morphocytochemistry and Flow Cytometry in Acute Leukaemia: A Cross-sectional Study
Introduction: Acute leukaemias are rapidly progressive haematological malignancies that require timely and accurate lineage classification to guide appropriate treatment. Morphology and cytochemical staining have traditionally played a central role in diagnosis, particularly in resource limited…
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Clinico-histopathological Association in Lichenoid Dermatitis Patients: A Cross-sectional Study
Introduction: Lichenoid dermatitis is a frequently encountered histological pattern in dermatological lesions. It includes various diagnostic entities characterised by basal cell damage or lichenoid infiltrates. However, they have some histological features that point to a definite diagnosis…
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Utility of D2-40 Immunohistochemistry in Detecting Lymphovascular Invasion in Colorectal Carcinoma: A Cross-sectional Study
Introduction: The detection of Lymphovascular Invasion (LVI) has been recognised as an important prognostic factor in Colorectal Carcinoma (CRC), particularly in determining the adjuvant chemotherapy and further treatment plan. LVI on routine Haematoxylin and Eosin (H&E) section are often…
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Determination of Haemoglobin Variants by High Performance Liquid Chromatography in Patients with Moderate to Severe Anaemia: A Cross-sectional Study in Tertiary Care Hospital, South Bangalore, India
Introduction: Haemoglobinopathies are among the most common hereditary disorders in India and represent a major public health problem. Their management requires lifelong treatment such as transfusions, chelation therapy, and repeated investigations, causing significant socio-economic burden on…
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Utility of Histopathology, KOH Mount and Culture in the Diagnosis of Fungal Infections: A Cross-sectional Study
Introduction: Fungal infections are caused either by pathogenic fungi affecting the healthy population or by opportunistic fungi affecting the at-risk population. Patients may be asymptomatic, have mild infection or life threatening infection. Hence, a correct diagnosis is necessary for proper…
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Comparison between Cytology and Histopathology of Lung Tumours: A Cross-sectional Study
Introduction: Lung cancer is the leading cause of cancer deaths world-wide, predominantly Non-Small Cell Lung Cancers (NSCLC), consisting mainly of adenocarcinoma, followed by squamous cell carcinoma, Adenosquamous carcinoma, and large-cell anaplastic carcinoma. For early diagnosis, bronchoalveolar…
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Microbiological and Clinical Profiles of Bloodstream Infections in Adult Intensive Care Unit Patients: A Prospective Observational Study from a Tertiary Care Teaching Hospital of Rural Gujarat, India
Introduction: Bloodstream Infections (BSIs) are among the most severe healthcare-associated infections encountered in Intensive Care Units (ICUs) and are associated with increased morbidity, mortality, prolonged hospital stays, and higher healthcare costs. The emergence of Multidrug-Resistant (MDR)…
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Clinical and Biochemical Profile of Women with Polycystic Ovary Syndrome: A Cross-sectional Study
Introduction: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder associated with metabolic and hormonal bnormalities that predispose women to long-term health complications. Alterations in serum magnesium levels, lipid profile, thyroid function, and glycaemic status may contribute to…
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Prognostic Value of CD8 and its Association with Stroma in Periampullary Carcinoma: A Cohort Study
Introduction: Periampullary Carcinoma (PAC) is a rare gastrointestinal malignancy originating from within 2 cm of the Ampulla of Vater. It accounts for 0.5-2% of gastrointestinal cancers and includes Ampullary Carcinoma (AC), Pancreatic head Carcinoma (PC), Distal Common bile duct Carcinoma (DCC)…