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Frontiers in Chemistry
Scopus
ISSN 2296-2646 · Frontiers Media S.A. · 8.479 artikel di indeks
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Artikel Jurnal
Mesoporous silica nanoparticles--based functional platforms for breast cancer therapy: technological advancements
Mesoporous silica nanoparticles (MSNs) offer remarkable opportunities for the loading and delivery of drugs and other small molecules due to their large specific surface area, tunable mesoporous pore size, ease of modification, and excellent biocompatibility. The active silica hydroxyl groups…
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The three-dimensional structure of a proton-pumping pathway, the H-pathway, is evolutionarily conserved in all three families of cytochrome c oxidase
The O2 reduction site of bovine cytochrome c oxidase (CcO) comprises two redox-active metal centers: Fea3 and CuB. O2 is reduced at Fea3 by four electrons transferred from cytochrome c in the P-side phase. Three proton-conducting pathways, D, K, and H, have been identified. Two distinct…
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Synthesis, characterization and surface properties of an organosilicon surfactant
In order to explore alternative substances for traditional fluorocarbon surfactants while maintaining high surface activity, this study successfully designed and synthesized an organosilicon surfactant (SiCH) containing a hydroxyl quaternary ammonium salt. Its molecular structure was confirmed by…
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Artikel Jurnal
Geochemical fate of lead in contaminated residential soils following application of amendments for lead immobilization
BackgroundLead (Pb) persists in urban soils, where its partitioning among geochemical fractions governs mobility, bioavailability, and human health risk. These fractions are strongly controlled by soil physicochemical properties, necessitating site-specific remediation strategies.MethodsThis study…
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Artikel Jurnal
Selective isomerization of 2,3-disubstituted butanediacetal esters and thioesters using lithium and sodium enolates: effects of bases and additives on stereoselectivity
The study concerned the stereoselective isomerisation of S2,S3-diethyl (2R,3R,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxane-2,3-dicarbotioate to the isomer S2, S3-diethyl (2R,3S,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxane-2,3-dicarbotioate via stable lithium and sodium enolates. For this purpose…
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Influence of substitution patterns on the antimicrobial properties of pyrrole sulfonamide scaffolds
Two series of sulfonamide derivatives featuring a pyrrol-2-one core were synthesized and evaluated for their antimicrobial and anti-virulence features using Escherichia coli, Pseudomonas aeruginosa, and Candida albicans strains, in planktonic and biofilm growth state. Fourteen substituents were…
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Absolute quantification of tumor necrosis factor-alpha by isotope dilution mass spectrometry
Tumor necrosis factor-α (TNF-α) is an important inflammatory mediator and has been widely recognized as a diagnostic biomarker for various autoimmune and infectious diseases in clinical practice, such as rheumatoid arthritis. In this study, we established an SI-traceable reference method to…
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Self-thickening mechanism of an amphiphilic polymer during acid rock reaction and performance testing
Using acrylamide, methacryloyloxyethyl trimethyl ammonium chloride, and 2-acrylamido-2-methylpropanesulfonic acid as raw materials, an amphoteric ionic self-thickening acid ADAM was prepared. The viscosity changes of ADAM during the acid-rock reaction process were studied, demonstrating that the…
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GO/MNPs–TEA–CuI in water: a green and efficient catalytic system for multicomponent preparation of highly substituted imidazoles and oxazoles
A sustainable and highly efficient catalytic protocol has been developed employing graphene oxide-supported magnetic nanoparticles functionalized with triethanolamine and copper(I) iodide (GO/MNPs–TEA–CuI) for the synthesis of functionalized imidazole and oxazole derivatives. This magnetically…
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Artikel Jurnal
Protein compound macrophage migration inhibitory factor for diagnosing postmenopausal osteoporosis
Postmenopausal osteoporosis (PMOP) is a bone metabolic disorder characterized by reduced bone mass and deterioration of bone microarchitecture, and its early diagnosis is essential for improving clinical outcomes. However, reliable biochemical markers for the early detection of PMOP remain…
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Thermally tunable naphthalene diimide solvates enable selective sensing, reversible photochromism, and anti-counterfeiting applications
Recent studies have highlighted the potential of naphthalene diimide (NDI)-based molecules for their stimuli-responsive and optical properties. In this work, we report two naphthalene diimide (NDI)-based solvates, designated as NDI-1 and NDI-2, were successfully synthesized from 4-aminopyridine and…
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Application of machine learning models in pharmaceutical engineering for prediction of pharmaceuticals solubility in supercritical solvent: study on phenytoin solubility
This research investigates the predictive performance of ensemble learning models, specifically Bagging, when combined with weak models including Polynomial Regression (PR), K-Nearest Neighbors (KNN), and Gamma Regression (GR) to estimate drug solubility in supercritical carbon dioxide as the…
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Analysis of volatile compounds in Aglaia odorata flower extracts with different possessing methods by HS-SPME-GC-MS and E-nose
IntroductionTo investigate the impact of different processing methods on the volatile components in Aglaia odorata flower extract (AOFEs).MethodsHeadspace solid-phase microextraction coupled with gas chromatography-mass spectrometry and electronic nose (E-Nose) analysis were employed to…
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Artikel Jurnal
Salvianolic acid B attenuates cellular senescence and age-related decline in muscle function via dual mTOR/TP53INP2-autophagy regulation
BackgroundThe rapid aging of the global population and the high prevalence of age-related diseases have positioned anti-aging as a critical research priority. Natural products have recently gained significant attention in anti-aging research owing to their multi-target and multi-pathway mechanisms…
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Vesicles: a supramolecular tool to achieve organic reactions in aqueous media
Vesicles are fascinating supramolecular aggregates that can provide an interface-rich microenvironment and confined space. They can incorporate hydrophilic materials in their aqueous core and hydrophobic materials in their bilayer membrane. Thus, they can be utilized to perform organic reactions in…
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Novel Roman domination-based graph energies for QSPR analysis of neuroprotective herbal compounds in Alzheimer’s disease treatment
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder for which U.S. Food and Drug Administration (FDA)-approved drugs provide only temporary symptomatic relief and often cause adverse effects. Plant-derived bioactive phytochemicals are emerging as promising alternatives due to their…
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Artikel Jurnal
Evaluating the products of low power, sealed vessel microwave pyrolysis of microalgae
The products of low power, sealed vessel microwave pyrolysis of a proprietary microalga, ALG01, similar to Eustigmatophyceae, were evaluated at fixed power (50 W, 100 W and 150 W). The afforded biochars were characterised by CHNS, ATR-IR, SS 13C NMR, TGA and SEM, whilst the bio-oils were…
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