387 hasil
Menampilkan 1–20 · 0,13 detik · RSS
Dermatopathology
Scopus
ISSN 2296-3529 · MDPI AG · 387 artikel di indeks
-
Artikel Jurnal Teks lengkap
Skin Basal Cell Carcinosarcoma in a Trichoblastic Guise—Molecular Characterization of a Novel Entity Mimicking a Pyoderma Gangrenosum
Basal cell carcinosarcomas (BCCSs) are rare, aggressive biphasic epithelial–mesenchymal neoplasms typically occurring in elderly patients. Their nonspecific clinical presentation may mimic inflammatory disorders, necessitating histopathological examination. We characterize a novel cutaneous BCCS…
-
Artikel Jurnal Teks lengkap
Scalp Biopsies for Alopecia
Background: Hair loss is one of the most common reasons patients seek dermatologic evaluation. Although clinical examination and trichoscopy establish the diagnosis in most cases, scalp biopsy remains essential when findings are inconclusive, when cicatricial alopecia is suspected, or when…
-
Artikel Jurnal Teks lengkap
Desmoplakin-Related Arrhythmogenic Cardiomyopathy Carriers and Desmosomal-Type Acantholysis: A Previous Description of the Keratinocyte “Fingerprint Sign”. Comment on Metze et al. Desmosomal-Type Acantholysis—A New Histologic Pattern Related to Mutations of Genes for Desmosomal Proteins. Dermatopathology 2026, 13, 17
We read with great interest the article by Metze et al [...]
-
Artikel Jurnal Teks lengkap
Reply to Fernández-Flores, Á. Desmoplakin-Related Arrhythmogenic Cardiomyopathy Carriers and Desmosomal-Type Acantholysis: A Previous Description of the Keratinocyte “Fingerprint Sign”. Comment on “Metze et al. Desmosomal-Type Acantholysis—A New Histologic Pattern Related to Mutations of Genes for Desmosomal Proteins. Dermatopathology 2026, 13, 17”
We are grateful for the commentary by Ángel Fernández-Flores on our concept of “desmosomal-type acantholysis”, a distinct histologic form of acantholysis associated with mutations in genes encoding desmosomal proteins [...]
-
Artikel Jurnal Teks lengkap
TRPV4 Regulates Imiquimod (IMQ)-Induced Psoriasis via CaMKKβ/AMPK and Calmodulin/Akt-Mediated Autophagic Signaling Pathways in Juvenile Murine Keratinocytes
Background: Psoriasis is a chronic inflammatory skin disease due to genetic susceptibility and multiple environmental factors. Transient receptor potential vanilloid 4 (TRPV4) is a calcium channel extensively expressed throughout the body with multiple functions. However, the role of TRPV4 in…
-
Artikel Jurnal Teks lengkap
Basic Principles of Skin Biopsy Optimization in Dermatopathology
Skin biopsy is one of the most valuable diagnostic procedures in dermatology, particularly when clinical findings alone are insufficient to establish a diagnosis. However, obtaining an accurate histopathological diagnosis depends on multiple steps, and errors at any stage of the biopsy pathway may…
-
Artikel Jurnal Teks lengkap
Nail Unit Specimens
Histologic submission and processing of nail unit specimens require special attention, primarily because of the contrast between the hard plate and the delicate matrix/bed tissue. Adherence of the plate to the glass slide is particularly challenging, and a protocol is included to address this…
-
Artikel Jurnal Teks lengkap
Emerging In Vivo and Ex Vivo Optical Imaging Technologies in Dermatology and Dermatopathology
Optical imaging technologies are increasingly reshaping the interface between clinical dermatology and dermatopathology. In vivo reflectance confocal microscopy (IV-RCM), line-field confocal optical coherence tomography (LC-OCT), and ex vivo confocal microscopy (EV-CM) provide tissue-level…
-
Artikel Jurnal Teks lengkap
Quantifying the Interplay Between PRAME Expression and Classical Morphology: A Multivariable Analysis of 954 Suspected Melanocytic Lesions
The integration of immunohistochemical biomarkers like PRAME (Preferentially Expressed Antigen in Melanoma) into the histomorphological assessment of melanocytic lesions is gaining prominence. While PRAME’s diagnostic value is widely recognized, its independent weight compared directly to classical…
-
Artikel Jurnal Teks lengkap
Cutaneous Squamous Cell Carcinoma Across the Pre-COVID-19, COVID-19 and Post-COVID-19 Eras: Epidemiology, Risk Stratification, Tumour Aggressiveness, and Clinical Outcomes
Background/Objectives: Cutaneous squamous cell carcinoma (cSCC) is the second most common non-melanoma skin cancer (NMSC) and represents the leading cause of NMSC-related deaths. Despite its growing global burden, comprehensive epidemiological and clinicopathological data from Easter Europe remains…
-
Artikel Jurnal Teks lengkap
Cutaneous Pediatric Vasculitis: A Clinico-Histopathological Overview of Common and Novel Entities
Vasculitis encompasses a heterogeneous group of diseases characterized by the inflammation of blood vessels. In children, the diagnosis of vasculitis with cutaneous involvement relies on a combination of clinical evaluation, histopathological examination, and, in some cases, genetic investigations…
-
Artikel Jurnal Teks lengkap
Exploring β3-Adrenergic Receptor, HIF-1α, and CD31 Interplay in the Microenvironment of Atypical Melanocytic Lesions
Background: Melanoma incidence is rising rapidly worldwide and stands out due to its high lethality. Despite advances in clinical treatment and in understanding melanoma-sensitive genes and molecular pathogenesis, a specific area of ongoing research is the connection between stress-related…
-
Artikel Jurnal Teks lengkap
Surgical Management of Cutaneous Neoplasms: Biopsy Strategies, Margin Assessment, and Special Considerations
There has been a rising incidence of both melanoma and non-melanoma skin cancers, requiring knowledge of effective management techniques. This review aims to provide a structured approach to biopsy selection, surgical excision, and margin assessment for common cutaneous neoplasms.
-
Artikel Jurnal Teks lengkap
Hydroxychloroquine-Induced AGEP with Positive Rechallenge: A Case Report and Mini Review of the Literature
Background/Objectives: Hydroxychloroquine is widely used in the treatment of autoimmune and dermatologic diseases; however, it may rarely induce severe cutaneous adverse reactions. Acute Generalized Exanthematous Pustulosis is an uncommon, acute pustular eruption most frequently associated with…
-
Artikel Jurnal Teks lengkap
Non-Melanocytic Histopathological Clues for Melanoma Diagnosis: A Practical Review of Solar Elastosis, Stromal Regression, and Epidermal Reaction Patterns. Do Old-School Clues Still Matter?
Histopathologic melanoma diagnosis extends beyond melanocytic cytology to encompass non-melanocytic features: solar elastosis patterns, stromal regression, adnexal relationships, epidermal reaction patterns, and the host inflammatory response. These “old school” low-power clues are particularly…
-
Artikel Jurnal Teks lengkap
Halo Nevus as a Self-Limited Model of Melanocyte Autoimmunity: Bridging Vitiligo, Immune Resolution, and Tumor Immunology—A Narrative Review
Halo nevus (HN), also known as Sutton nevus or leukoderma acquisitum centrifugum, is a melanocytic lesion characterized by a depigmented halo surrounding a central nevus. Although HN is a benign dermatological condition, increasing evidence indicates that HN represents a dynamic in vivo model of…
-
Artikel Jurnal Teks lengkap
Diagnosis of Syphilis in Paraffin-Embedded Skin Biopsies: Comparison of Treponema pallidum Immunohistochemistry and Polymerase Chain Reaction in Primary and Secondary Stages of Disease
Syphilis remains one of the most prevalent sexually transmitted infections. Serology is the diagnostic gold standard, but skin biopsies aid in ambiguous cases. Treponemas can be detected in tissue by immunohistochemistry (IHC) and polymerase chain reaction (PCR); however, their comparative…
-
Artikel Jurnal Teks lengkap
Mitotic Proliferative Nodule Within a Giant Congenital Nevus: One Case Report and Updated Review
Proliferative nodules (PNs) are benign, well-limited melanocytic proliferations that can occur within congenital nevi, particularly larger ones. Although they may mimic melanoma clinically and histologically, PNs are characterized by a monomorphic, well-defined cell population with peripheral…
-
Artikel Jurnal Teks lengkap
Flesh-Colored Papules on the Glans Penis
A 23-year-old man reported a 3-year history of slowly growing, slightly itchy, flesh-colored papules on the distal glans penis. He denied any history of trauma or previous treatment. Additionally, he experienced no difficulties with urination, discharge, or erectile function. Upon examination…
-
Artikel Jurnal Teks lengkap
Cutaneous Melanoma in Adolescents and Young Adults Versus Older Patients: Clinical and Histopathological Differences in Western Romania
Aim: This study aimed to identify the clinical and pathological features of primary cutaneous melanomas in young patients, comparing them with those of older patients. Materials and Methods: We performed a retrospective study observing the differences with respect to clinical and pathological…