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Frontiers in Cell and Developmental Biology
Scopus
ISSN 2296-634X · Frontiers Media S.A. · 13.979 artikel di indeks
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Artikel Jurnal
Elucidating the protective mechanisms of umbilical cord mesenchymal stem cells against stenosis-induced deep venous thrombosis during pregnancy: a transcriptomic and metabolomic study
ObjectiveThis study aims to integrate metabolomics and transcriptomics data to investigate the protective effects of umbilical cord mesenchymal stem cells (UC-MSCs) on obstetric deep vein thrombosis (DVT) and to elucidate the underlying molecular mechanisms.MethodsA pregnant rat model of DVT was…
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Artikel Jurnal
Baicalin attenuates cisplatin-induced cochlear hair cell damage by modulating the ROS-p38 MAPK signaling pathway
IntroductionCisplatin-induced ototoxicity remains a major clinical challenge in chemotherapy, with limited pharmacological strategies available to prevent auditory damage. In this study, we explored the protective potential of baicalin, a flavonoid compound, against cisplatin-triggered cochlear…
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A switch from α5β1 to αvβ3 integrin activity contributes to the development of a profibrotic mesenchymal phenotype in trabecular meshwork cells
PurposeFibrogenic changes in the trabecular meshwork (TM) are considered to be a major cause for the restriction in aqueous humor outflow from the anterior chamber associated with primary open angle glaucoma. In this study, we investigated whether integrin switching from α5β1 to αvβ3 integrin…
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Alternative splicing regulates PACC1 function and promotes acidosis-induced cytotoxicity
IntroductionPACC1 (also named TMEM206) encodes a proton-activated chloride channel implicated in acid-induced cell death, but its tissue distribution, cellular expression, and isoform-specific roles are incompletely understood.MethodsWe mapped PACC1 expression and splicing across normal human…
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Artikel Jurnal
HIF-1α at the intersection of hypoxia, ferroptosis-associated stress, and cell death crosstalk in osteomyelitis
Osteomyelitis is a severe inflammatory disease of bone tissue primarily caused by bacterial infections, most commonly Staphylococcus aureus. Its complex pathophysiology creates a unique hypoxic and inflamed microenvironment, which leads to the significant upregulation of the key transcriptional…
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Artikel Jurnal
Hypertrophic cardiomyopathy: comprehensive insights into pathogenic genes and genotype-phenotype associations
Hypertrophic cardiomyopathy (HCM) is a genetically heterogeneous cardiac disorder characterized by unexplained left ventricular hypertrophy and represents a leading cause of morbidity and sudden cardiac death, particularly in young adults and athletes. Early studies focused on morphological…
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Cellular plasticity: a double-edged sword driving malignant transformation and adaptive remodeling in stem cells
This review systematically examines the dual roles of cellular plasticity in stem cell biology. Stem cells leverage their inherent plasticity to achieve adaptive tissue remodeling, including migration, differentiation, and microenvironment interactions during development, regeneration, and…
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Artikel Jurnal
The D826V point mutation in IREB2 induces lipogenesis in adipose tissues
BackgroundIREB2 is an RNA-binding protein that modulates cellular iron uptake and storage by regulating ferritin expression. Mutations in the IREB2 gene have been shown to induce degradation of the IREB2 protein, resulting in the upregulation of FTH1 protein expression, which contributes to iron…
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Artikel Jurnal
NSUN5 and RNA m5C epitranscriptomic regulation in tumor progression
NSUN5 is a pivotal RNA 5-methylcytosine (m5C) methyltransferase that predominantly catalyzes site-specific m5C modifications in ribosomal RNA (rRNA), thereby regulating ribosome assembly, selective translation, and cellular stress adaptation. Recent studies have demonstrated that NSUN5 is…
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Comparative performance of GPT-4, GPT-o3, GPT-5, Gemini-3-Flash, and DeepSeek-R1 in ophthalmology question answering
BackgroundThe application of large language models (LLMs) in medicine is rapidly advancing, showing particular promise in specialized fields like ophthalmology. However, existing research has predominantly focused on validating individual models, with a notable scarcity of systematic comparisons…
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Artikel Jurnal
Circulating exosomal miR-550a-5p/miR-665 identify coronary microvascular dysfunction and drive endothelial–myocyte crosstalk in type 2 diabetes
ObjectiveThis study aimed to identify circulating exosomal microRNAs for early detection of coronary microvascular dysfunction (MD) and stratification of myocardial injury risk in type 2 diabetes, and to test whether miR-550a-5p derived from endothelial cell models mechanistically links endothelial…
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Artikel Jurnal
STC2 promotes anoikis resistance by modulating TGIF1 mRNA stability in colorectal cancer
BackgroundStanniocalcin-2 (STC2), a glycosylated protein originally identified in the endocrine glands of fish, plays multiple biological roles in cancer. However, its functional significance and molecular mechanisms in colorectal cancer (CRC) remain unclear.MethodsBioinformatic analyses and CRC…
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Branched-chain amino acid transaminases as promising targets in tumor therapy
Branched-chain amino acid transaminases (BCATs), including BCAT1 and BCAT2, play pivotal roles in tumorigenesis and therapeutic resistance in various cancers. These enzymes regulate branched-chain amino acid (BCAA) metabolism and influence critical oncogenic pathways such as mTOR, PI3K/AKT, and…
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Artikel Jurnal
Platelet-activating factor modulates apoptotic gene expression in developing sea urchin embryos
Examining gene expression patterns during early embryonic development is essential for understanding genetic disorders and fertility. The accessibility, cost-effectiveness, and reproducibility of sea urchin embryos have offered an effective model for studying how gene expression is regulated in…
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Artikel Jurnal
Multi-scale systems toxicology defines a KLF5-centered adverse outcome pathway linking DEHP exposure to pancreatic cancer progression and signaling programs relevant to therapy tolerance
Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous plasticizer implicated in pancreatic carcinogenesis, yet the molecular initiating events and adverse outcome pathways (AOPs) linking exposure to disease mechanisms remain poorly resolved. In this study, we integrated a multi-scale systems toxicology…
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WWC proteins as emerging biomarkers and therapeutic targets in cancer pathogenesis
WW and C2 domain-containing (WWC) proteins have emerged as pivotal regulators of cancer initiation, progression, and therapeutic resistance. This review synthesizes current evidence demonstrating that WWC1, WWC2, and WWC3 exert context-dependent effects across malignancies, with WWC2 consistently…
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Artikel Jurnal
Development of gold nanoparticles stabilized by PLGA and PVA for application in photothermal therapy
IntroductionIn today's world, cancer remains a major public health problem. Consequently, there has been a focused investigation of alternative therapeutic approaches to address this ongoing health concern. In this study, PLGA-gold nanomaterials were produced through various processes to determine…
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Artikel Jurnal
TRIM26 deficiency drives gastric cancer lymph node metastasis via TGF-β signaling activation and modulates gemcitabine response
BackgroundGlobally, gastric cancer (GC) is a predominant cause of cancer-related death. Lymph node metastasis (LNM) and chemoresistance constitute two major barriers to improving outcomes, as LNM signifies advanced disease and chemoresistance consequently leads to treatment failure. This study…
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