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Frontiers in Molecular Biosciences
Scopus
ISSN 2296-889X · Frontiers Media S.A. · 6.165 artikel di indeks
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Artikel Jurnal
Plasmodium infection fully activates the immune system in peripheral blood and tumor microenvironment in a murine Lewis lung cancer model
BackgroundPlasmodium infection has been proven to activate antitumor immune responses. This study comprehensively analyzes the immune cell populations in peripheral blood and tumor microenvironment to elucidate the potential immunological mechanisms by which Plasmodium infection inhibits tumor…
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Lipid remodeling and ferroptosis in phosphatidylcholine-mediated tumor–stroma crosstalk
Tumor progression and therapy resistance are formed not only by cancer cell intrinsic mechanisms but also by dynamic interactions with the surrounding tumor stroma. Metabolic regulation is central to these interactions, with lipid pathways emerging as critical determinants of cell fate. A growing…
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Artikel Jurnal
Longitudinal profiling of serum ADAM17 across clinical stages in multiple myeloma: a dynamic biomarker and its association with T cell alterations
BackgroundMultiple myeloma (MM) is the second most common hematologic malignancy in adults. Owing to marked heterogeneity in pathogenesis, clinical presentation and prognosis, the 5-year survival rate remains approximately 50%. Robust and clinically actionable biomarkers are therefore urgently…
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Artikel Jurnal
Arsenic trioxide-induced acute kidney injury: OPA1- and Drp1-mediated mitochondrial dynamics imbalance, PINK1/Parkin-dependent mitophagy, and Chuanhuang Fang III
PurposeAcute kidney injury (AKI) remains a global health concern with limited therapies. Among its causes, arsenic (AS)-induced AKI (AI-AKI), exemplified by the antitumor agent arsenic trioxide (ATO), represents an emerging clinical challenge. Despite its clinical efficacy in treating AI-AKI, the…
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Bioenergetic and immunological characterization of cryopreserved peripheral blood mononuclear cells (PBMCs) isolated from blood and buffy coat
BackgroundMitochondrial dysfunction (MD) and inflammaging are hallmarks of non-communicable diseases and play a pivotal role in the ageing process. Determination of mitochondrial function (MF) in Peripheral Blood Mononuclear Cells (PBMCs) represents a minimally invasive method for assessing the…
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Non-coding RNA transcripts and their exosomal counterparts in the pathogenesis, diagnosis, and treatment of skin cancers, with a focus on melanoma
Skin malignancies, including melanoma and non-melanoma cancers, are the most common cancers worldwide, with increasing incidence and fatality rates. Malignant melanoma (MM) is a highly aggressive cancer with poor prognosis, and despite various therapies, it remains a serious threat due to factors…
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Pompe disease: a country-wide molecular screening in a cohort of 15,068 study participants
IntroductionPompe disease (PD) is a rare inherited recessive autosomal disorder caused by pathogenic nucleotide variants within the gene GAA, encoding Acid alpha-glucosidase (GAA), the lysosomal enzyme catalyzing glycogen breakdown to glucose.MethodsWe performed molecular screening in a cohort of…
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Biophysical insights into recombinant Zeocin binding protein: conformational stability and folding dynamics across pH and temperature
Zeocin-binding protein (ZBP) confers resistance to the bleomycin family of antibiotics across a wide variety of prokaryotic and eukaryotic hosts. Zeocin is a bleomycin derivative used in cancer treatment. ZBP’s mechanism involves binding to Zeocin, shielding DNA from damage. In protein folding…
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Redox metabolism in cell senescence: focusing on contributions from the metabolomic field
Cell senescence is triggered by stressful stimuli, including telomere attrition, genotoxic agents, and strong mitogenic signals. This state is characterized by proliferation arrest and acquisition of a senescence-associated secretory phenotype. Senescent cells secrete growth factors, chemokines…
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Short-term continuous light exposure induces hippocampal rhythmic and functional alterations: a multi-timepoint metabolomics study
IntroductionShort-term continuous light exposure disrupts circadian rhythms and impairs cognitive function, yet its specific effects on dynamic metabolic oscillations within the hippocampus remain unclear.MethodsThis study investigated the impacts of short-term (7-day) continuous light exposure…
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Integrating causal human genetics and In vivo transcriptomics to uncover a shared lipid-centric architecture in metabolic and neurocognitive disease
BackgroundMetabolic disorders and neurocognitive diseases frequently co-occur, yet the specific mechanisms driving this comorbidity remain elusive. While epidemiological associations are well-documented, the causal links between these conditions are complex and incompletely understood…
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RNA-based therapies for colorectal cancer: targeting the β-catenin pathway via microbiota -modulated miRNAs
Colorectal cancer (CRC) is a significant problem with worldwide public health consequences. One key factor in the genesis and progression of CRC is the aberrant upregulation of the Wnt/β-catenin signaling pathway. Inhibitors designed to target β-catenin directly have not been effective in clinical…
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A validated LC-ESI-MS/MS assay for simultaneous plasma quantification of 11 antimicrobials to support personalized dosing in critically ill children
IntroductionCritically ill patients with severe infections demonstrate profound alterations in pharmacokinetic behavior. Therapeutic drug monitoring (TDM)-informed antimicrobial dose optimization is thus essential in intensive care settings to ensure maximal bactericidal activity while mitigating…
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S100A12 drives inflammatory and metabolic reprogramming in sepsis-associated acute kidney injury
Sepsis-associated acute kidney injury (SA-AKI) is a severe complication of sepsis characterized by dysregulated inflammation, endothelial injury, and metabolic reprogramming. Among the numerous inflammatory mediators involved, S100 calcium-binding protein A12 (S100A12), a neutrophil-derived…
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Investigating circulating expression profile for H19, MEG3, and MIAT long noncoding RNAs with miR-135a and miR-29a in chronic kidney disease and renal hemodialysis patients: interrelations with serum sclerostin
Background and aimChronic kidney disease (CKD) incorporates a variety of progressive kidney function declines, ranging from mild impairment to end-stage renal disease (ESRD). As a global public health problem, early detection and monitoring remain critical for improving patient outcomes. This study…
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Disulfidptosis-related genes signature predicts prognosis and immune microenvironment in colon cancer
BackgroundColon cancer (CC), characterized by high incidence and mortality, ranks among the most prevalent digestive malignancies, and reliable molecular tools to predict prognosis and immunotherapy response are needed. Disulfidptosis is a recently identified form of programmed cell death induced…
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Antigen-specific T Cell precursor frequency influences the proliferation of stem-like T Cells in tumor-draining lymph nodes and anti-tumor immune responses
BackgroundWhile immune checkpoint blockade has transformed the landscape of cancer therapy, variability in patient responses constrains its therapeutic potential. Tumor-specific stem-like T (TSL) cells sustain durable immunity through self-renewal and differentiation. However, upstream regulators…
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Advances in cardiovascular supplementation: mechanisms, efficacy, and clinical perspectives
The integration of nutritional supplementation into cardiovascular disease (CVD) prevention and management represents a dynamic and often contentious field. Moving beyond traditional paradigms, recent research has sought to elucidate the precise molecular mechanisms, establish robust clinical…
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Artikel Jurnal
Multifaceted roles of fibronectin type III domain containing 3B (FNDC3B) in cell biology and signaling
FNDC3B is an endoplasmic reticulum (ER)-anchored transmembrane protein with diverse roles in cell adhesion, migration, and growth signaling. Recognized as multifunctional, it contributes to key cellular processes such as adhesion, proliferation, differentiation, and migration, yet its molecular…
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