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RADS Journal of Biological Research & Applied Science
ISSN 2305-8722 · Jinnah University for Women · 276 articles in the index
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Journal Article Full text
Detection of Class 1 Integrons in Drug-Resistant Bacteria Isolated from Raw Meat and Milk of Lahore, Pakistan
Background: The problem of antimicrobial resistance in foodborne bacteria has become an increasing threat to the world as antibiotics no longer have an effect on the infections. Objective: The aim of this study was to identify antibiotic resistance genes and class 1 integrons in bacterial isolates…
Also available at: DOAJ
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Influence of Different Packaging Materials on the Shelf Life and Microbial Quality of Bread and Cookies
Background: Efficient packaging is profound for retaining impudence and increasing shelf stableness of baked goods by controlling moisture and microbial contamination. Aim: This study assessed the impact of different packaging materials such as Kraft paper bag, Metallic Mylar bag, and Ziploc bag on…
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In silico Evaluation of Friulimicin Interaction with Tuberculosis Necrotizing Toxin
Background: Tuberculosis is a severe disease showing a high global health burden, whereby the World Health Organization reported 10.6 million cases and 1.6 million deaths in 2021. Mycobacterium tuberculosis has significant survival chances with its complicated cell wall and virulence determinants…
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Antimicrobial and Gas Chromatography-Mass Spectrometric Analysis of the Ethyl-Acetate Extract of Chrysophyllum albidum (G. Don) Fruit Exocarp
Background: Chrysophyllum albidum is an edible fruit tree of tropical origin that may contain nutritive and medicinal components useful as food and therapeutic principles in humans. Objective: The study assessed the antimicrobial activity and phytochemical constituents of the ethyl-acetate extract…
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Host-Dependent Variation in the Antidiabetic Activity of Loranthus pulverulentus Collected from Two Host Species
Introduction: Loranthus pulverulentus is a parasitic plant traditionally used in some cultures as a homeostasis regulator. Literature reports suggest that bioactive compounds produced by a parasitic plant could potentially be influenced by the host plant's own chemical composition, playing a role…
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In-silico testing of Novel Steroidal Derivatives as FGFR1 Agonists for Enhanced Regeneration in Adult Tissues
Background: Fibroblast Growth Factors (FGFs) are a crucial superfamily of morphogenic proteins that play a critical role in embryonic development and tissue restoration. They are heavily implicated in wound healing. FGFR1 activation is key toward blastema tissue mediated regeneration. However…
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Development and Evaluation of Quality of Sausages Containing White Kidney (Phaseolus Vulgaris L.) Beans and Corn Starch
Background: The legume meat analogs are an eco-friendly and healthy alternative to the meat market. The present study emphasizes the preparation of functional plant-based sausages by using different ratio of white kidney beans (Phaseolus vulgaris L.) and corn starch to achieve the structural and…
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The Therapeutic Potential of Nigella sativa in Attenuating Stress-Induced Neurobehavioral, Biochemical and Oxidative Alterations in Rats
Background: Nigella sativa is a highly valued medicinal herb due to its therapeutic importance and has no side effects as in allopathic drugs; hence it is called as golden seed. It has been traditionally used to treat many diseases. Objective: Nigella sativa has been reported for its protective…
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Exploring the Effect of Carica papaya Leaf Extract on Platelets, Coagulation, and Tissue Morphology
Background: Platelets play a crucial role in wound healing and clot formation. They are derived from megakaryocytes. A low platelet count, known as thrombocytopenia, is a warning sign and is notably associated with many diseases, such as dengue fever. Due to the limited therapies available…
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Larvicidal Effect of Hyptis spicigera Aqueous Plant Extract on Anopheles and Culex Mosquito Larvae
Background: Mosquitoes are insects of public health importance because they transmit pathogens that cause a wide range of diseases. In recent times, attention has been shifted from the synthetic insecticides used in their control to plant extracts as potential insecticides for the control of…
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Distribution of Antibiotic Resistance Genes among Enterococcus Species Isolated from Bulk Soil of Karachi, Pakistan
Aims and Objective: Presence of Enterococcus species in the Microbiota of humans, animals and environment has been established. E. faecium and E. faecalis are the major species involved in nosocomial infections due to their ability to resist clinically important antibiotics. Soil, one of the most…
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Statistical Optimization of Expression Cassettes Encoding 1, 4-?-D-Glucan Glucohydrolase from A Novel Strain Aspergillus Oryzae IIB-6
Background: Exo-1, 4-?-D-glucan glucohydrolase (GGH) is a biological catalyst that catalysis the starch saccharification to produce glucose syrup, which is used as feedstock for fuel ethanol and high fructose corn syrup production. Objective: The study aimed to optimize cost-effective GGH…
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Triple-Parameter Optimization of Linezolid 600mg Tablets: Dissolution, HPLC, and UV Spectrophotometric Evaluation
Aims and Objectives: The current research’s target is to obtain the dissolution profile of various brands of Linezolid 600 mg tablets available in Karachi, Pakistan and the assay was also performed using both the UV Spectrophotometric Technique and High Performance Liquid Chromatographic…
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Nature's Pharmacy: Harnessing Plant and Animal-Derived Agents for Cancer Therapy
Objective and Background: Studies have shown that phytochemicals from plants like flavonoids, terpenes, and alkaloids and peptides from animal sources can be very effective in cancers remission. Current review explores the potential of natural compounds from plants and animal sources in cancer…
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Production of Alpha Amylase from Banana Peel Using Aspergillus niger
Background: Various chemicals and dyes used in paper production are xenobiotic in nature and pose significant environmental concerns. Objective: In this study, a fungal strain was isolated from contaminated paper mill effluent and identified as Aspergillus niger through standard microbiological and…
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Isolation and Screening of Marine Bacterial Metabolites against Beta-Lactamase-Producing Bacteria
Background: The emergence of antibiotic resistance underscores the urgent need for new therapeutic sources. Objective: In this study, seven marine bacterial isolates from seawater were screened for bioactive metabolites active against ?-lactamase–producing pathogens. Methodology: Each isolate was…
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Synthesis, Characterization and Antibacterial Activity of Silver Nanoparticles Prepared from Benzoin Gum (Loban) Extract
Background: The rise of multi-drug resistance poses a significant challenge for treating infectious diseases. Nanotechnology-particularly the use of silver nanoparticles (AgNPs)-offers promising solutions. Objective: To synthesize AgNPs using benzoin (reducing and stabilizing agent) as an…
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Review Review Review: Protein Subunit and DNA Vaccines Key Research, Development & Future Directions
Objective To analyze the advancements, difficulties, and potential of DNA and protein subunit vaccines, with an emphasis on manufacturing capabilities, safety, and effectiveness, and to gauge their influence on upcoming vaccine studies. Background Purified pathogen fragments are used in protein…
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Biological Potential of Homo- and Heteronuclear Complexes of Iminodiacetic Acid
Background: Natural ligands containing the carboxylate group have been broadly utilized in many coordination complexes because of their simple manufacturing strategies, magnificent chelation properties, and biological potential. The carboxylate ligands may bind to the metal atoms in a variety of…