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ERJ Open Research
Scopus
ISSN 2312-0541 · European Respiratory Society · 3.161 artikel di indeks
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Artikel Jurnal
Treatable traits in asthma associated with hospitalisations
Background Personalised medicine targets treatable traits with tailored therapy. Extrapulmonary traits, modifiable and related to asthma, were analysed for their association with hospitalisation rates. Methods We conducted an observational study of a general population cohort in Sweden, based on…
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Artikel Jurnal
Real-world effectiveness of biologic therapies in severe asthma patients ineligible for phase 3 randomised controlled trials of biologics: an analysis from the UK Severe Asthma Registry
Background Most patients in real-world severe asthma populations would not be eligible for biologic randomised controlled trials (RCTs), although observational evidence has confirmed the effectiveness of biologics in real-world populations. We therefore investigated whether satisfying specific RCT…
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Artikel Jurnal
Concavity of the maximal expiratory flow–volume curve, and incidence of COPD and respiratory symptoms: a population-based cohort study
Background Concavity of the maximal expiratory flow–volume curve is widely regarded as an early indicator of obstructive airways disease. However, its discriminatory accuracy for respiratory outcomes has remained poorly defined. We aimed to examine the discriminatory accuracy of concavity of the…
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Artikel Jurnal
Parental smoke exposure before age 15 years and offspring asthma trajectories from ages 7 to 53 years
Background and objective Paternal passive smoke exposure before 15 years of age was associated with offspring childhood asthma, but its association with asthma beyond childhood had not been investigated. We aimed to investigate such long-term association. Methods Data were from 1078…
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Artikel Jurnal
Mucociliary and cough clearance in primary ciliary dyskinesia as affected by mutations in RSPH1 or DNAH5
Background Primary ciliary dyskinesia (PCD) is a rare disease caused by mutations in >50 genes that impair the function of motile cilia. The clinical phenotype is heterogeneous and recent studies have begun to investigate genotype–phenotype relationships to better understand disease pathogenesis…
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Artikel Jurnal
Upfront combination therapy with nintedanib and anti-inflammatory agents for progressive pulmonary fibrosis: a multicentre, single-arm phase 2 study (TOP-ILD)
Objective Progressive pulmonary fibrosis (PPF) is a chronic interstitial lung disease (ILD) characterised by fibrotic progression and poor prognosis, with effective treatment strategies for previously untreated patients remaining unclear. This study evaluated the efficacy and safety of upfront…
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Artikel Jurnal
Reference equations for oscillometry in adults: data from the Austrian LEAD study
Background Determination of reference values of respiratory impedance (Z) measured by oscillometry is of utmost importance for its clinical usefulness. The aim of our study was to develop reference values for within-breath and total oscillometry measurements in adults (18–90 years of age). Methods…
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Artikel Jurnal
Effect of dyspnoea-oriented hypnosis as an adjunct to pulmonary rehabilitation on the affective dimension of dyspnoea and physical activity level: a randomised controlled trial
Background Pulmonary rehabilitation has limited long-term effects on physical activity levels in patients with COPD. Dyspnoea-related anxiety, part of the affective dimension of dyspnoea, is a major barrier to physical activity. This study assessed whether hypnosis as an adjunct to standard…
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Artikel Jurnal
Circulating biomarkers in subjects with progressive pulmonary fibrosis: data from the INBUILD trial
Background We investigated the prognostic potential of circulating biomarkers at baseline and the effects of nintedanib on changes in these biomarkers in subjects with progressive pulmonary fibrosis (PPF). Methods In the INBUILD trial, subjects with PPF received nintedanib (n=332) or placebo…
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Artikel Jurnal
The impact of positive airway pressure treatment on mortality and hospitalisation in obstructive sleep apnoea: a German database analysis
Background Obstructive sleep apnoea (OSA) is a prevalent disorder. No consistent mortality benefit from treating OSA has been reported in randomised controlled trials. This analysis of an age-and-sex-representative anonymised German public health insurance database from 2015–2020 investigated…
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Artikel Jurnal
High 18F-fluorodeoxyglucose uptake in positron emission tomography–computed tomography is associated with emphysema progression
Background Pulmonary emphysema on computed tomography (CT) is a risk factor for all-cause mortality in individuals with and without airflow limitation. The aim of this study was to assess whether 18F-fluorodeoxyglucose (FDG) lung uptake on positron emission tomography (PET)/CT is associated with…
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Artikel Jurnal
Predictors of COPD exacerbations differ between grades of airflow limitation
Background History of exacerbations is a predictor of future exacerbations in COPD but there are also predictors that are independent of exacerbation history. However, it is unclear whether their relative contribution is consistent across different degrees of airflow limitation. Methods This…
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Artikel Jurnal
Key spirometric determinants of future airflow obstruction in children with asthma
Background There is increasing concern about children with asthma developing progressive lung function impairment. The objective of the present study was to identify the best spirometric determinants of subsequent development of airflow obstruction (AO) in children with asthma in the clinic…
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Artikel Jurnal
A novel method to assess airway eosinophilia using sputum plugs
Background Sputum cytology utilising routine dithiothreitol (DTT) processing is a well-established method to assess airway eosinophilia. However, the multi-step nature of this protocol requires substantial resources, thereby limiting its broader clinical applicability. To address this, we evaluated…
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Artikel Jurnal
Key priorities to prevent avoidable asthma hospitalisations: insights from end-users
Background and objective Asthma remains a significant burden on health systems and individuals, with many hospitalisations in Australia considered preventable through improved management and community care. This study aimed to explore end-user perspectives on preventing potentially avoidable asthma…
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