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Allergies
Scopus
ISSN 2313-5786 · MDPI AG · 140 articles in the index
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Biologic Therapies for Severe Pediatric Asthma: Current Evidence, Clinical Indications, and Future Directions
Severe pediatric asthma remains a significant clinical challenge despite advances in conventional therapy. Some children continue to experience persistent symptoms, recurrent exacerbations, and substantial morbidity despite optimized treatment with inhaled corticosteroids and long-acting…
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Atopic Dermatitis in Otorhinolaryngology: Clinical Manifestations and Implications for Practice
Atopic dermatitis is a chronic inflammatory skin disease increasingly recognized as part of a broader atopic and type 2 inflammatory spectrum rather than a condition confined to the skin alone. Although its dermatologic burden is well established, its relevance to otorhinolaryngology remains…
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HLA Polymorphism and Allergenicity
The Human Leukocyte Antigen (HLA) system represents one of the most polymorphic genetic systems in humans and plays a central role in immune recognition. This review explores the complex relationship between HLA polymorphism and allergenicity. Allergic diseases are highly prevalent worldwide, and…
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Allergic Contact Dermatitis in Athletes: A Narrative Review of Allergens, Diagnosis, and Management
Allergic contact dermatitis (ACD) is an increasingly common condition among athletes due to repeated exposure to sport-specific equipment, environmental allergens, and topical products. Sweating and repetitive cutaneous trauma facilitate allergen penetration. Rubber accelerators, metals, textile…
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Barriers to Biologic Access in Atopic Dermatitis: Insurance, Cost, and Administrative Challenges
Biologic therapies have significantly improved outcomes for patients with moderate-to-severe atopic dermatitis (AD), yet access to these treatments remains uneven and frequently limited. This systematic review synthesizes evidence on insurance-related, financial, administrative, prescriber-level…
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Peripheral Eosinophilia: A Practical Clinical Approach to Evaluation and Management
Eosinophilia is a heterogeneous clinical finding ranging from benign reactive states to clonal hematologic disorders associated with significant morbidity. This narrative, practical clinical review provides a structured, mechanism-based approach to the evaluation and management of peripheral…
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IKZF1 Overexpression Is Associated with Inflammatory and ER Stress-Related Transcriptional Changes in Human Conjunctival Epithelial Cells
Background: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) with severe ocular complications (SOCs) are devastating mucocutaneous disorders characterized by chronic ocular surface inflammation and epithelial damage. Although genome-wide association studies have identified IKZF1…
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Food Allergy Without a Safety Net—Molecular Sensitisation Patterns and Family Quality of Life Among Bulgarian Children in a Setting Without Epinephrine Auto-Injectors
Pediatric food allergy is an increasing public health challenge associated with severe allergic reactions, psychosocial burden, and healthcare inequalities. This study aimed to characterise molecular sensitisation patterns among Bulgarian children with suspected food allergy using…
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Climate Change and the Increasing Burden of Allergies in Children
Allergic diseases are increasing globally, particularly among children, who are highly vulnerable due to critical windows of immune development. This review examines climate change as a key environmental determinant driving the rising burden of pediatric allergic diseases, including asthma…
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Recognizing the Clinical and Pathophysiologic Overlap Between Allergy and Lupus
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by diverse and evolving clinical manifestations, often resulting in delayed diagnosis and increased morbidity. Although traditionally viewed as distinct, allergic and autoimmune diseases share overlapping…
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Biological and Immunological Activities of Brazilian Wasp Venoms: Implications for Allergy and Ion-Channel Modulation
Background: Brazilian wasp venoms represent a clinically relevant yet underexplored source of bioactive molecules with important implications for allergy, toxicology, and neuropharmacology. This review discusses the biological and immunological activities of venoms from Neotropical wasp species…
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Exposome and Respiratory Allergic Diseases: A Structured Narrative Review
Background: Allergic respiratory diseases, primarily asthma and allergic rhinitis, affect hundreds of millions worldwide. Their rising prevalence reflects complex gene–environment interactions that the exposome framework organizes into external, internal, and social domains shaping the development…
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Feature Papers 2025
The Special Issue “Feature Papers 2025” of Allergies comprises nine contributions that cover a wide range of allergy-related concerns [...]
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Antibiotic Allergy Labeling in Primary Care: Challenges, Consequences, and a Path Forward
Approximately 10% of the general population reports a penicillin allergy, making it one of the most commonly documented drug allergies in clinical practice. Yet formal evaluation confirms true hypersensitivity in fewer than 10% of these cases. This gap has practical consequences. Patients who carry…
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From Infancy to Adolescence: The Developmental Trajectory of Food Allergy and Its Relationship with Eosinophilic Esophagitis–Mechanisms, Epidemiology, and Emerging Therapies
Food allergy (FA) and eosinophilic esophagitis (EoE) represent two of the most rapidly increasing allergen-driven conditions in pediatric medicine. Both diseases share key immunological features, including Th2 polarization and epithelial barrier dysfunction. Over the past two decades, compelling…
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Olfactory Function as a Candidate Endpoint of Type 2 (Th2) Inflammation: Translational Rationale from Humans to Dogs
Type 2 inflammation is a central immunopathogenic driver of chronic immune-mediated disease, characterized by IgE polarization, eosinophilia, epithelial barrier disruption, and tissue remodeling. In veterinary medicine, especially in canine atopic and allergic disorders, the absence of validated…
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Anaphylaxis to Proton Pump Inhibitor and SARS-CoV-2 Vaccine: What Is the Link? A Case Report and Review of the Literature
The widespread use of proton pump inhibitors (PPIs) in clinical practice has increased the number of related hypersensitivity reactions (HSRs). The active ingredient is not always responsible for the reaction. In some cases, HSRs may be related to the excipients contained in the drug. The adverse…
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Allergic Diseases in Children Born to Mothers with Gestational Diabetes Mellitus
Background: Gestational diabetes mellitus (GDM) is an increasingly prevalent metabolic disorder of pregnancy. Beyond its well-established metabolic consequences, growing evidence suggests that exposure to maternal hyperglycemia during fetal life may influence immune system development and increase…
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Atopic Dermatitis: Contemporary Concepts in Epidemiology, Pathogenesis, Assessment, and Targeted Treatment
Atopic dermatitis (AD) is a chronic, relapsing inflammatory dermatosis characterized by pruritus, eczematous lesions, and a fluctuating course. It imposes substantial quality-of-life and economic burdens through sleep disturbance, pain, psychosocial distress, and frequent healthcare utilization…
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Cross-Kingdom Network Analysis of Bacterial and Fungal Communities in Allergic Rhinitis, Asthma, and Healthy Controls
Bacterial and fungal airway communities play a critical role in allergic respiratory diseases, yet they are often studied independently despite evidence of cross-kingdom ecological interactions. We investigated bacterial–fungal interactions across allergic rhinitis (AR), asthma (AS), allergic…