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Journal of Immunology Research
Scopus
ISSN 2314-7156 · Wiley · 3,131 articles in the index
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Journal Article
Role of Scar-Associated Macrophages in Organ Fibrosis Diseases
Fibrosis refers to the scarring and hardening of tissue resulting from the excessive deposition of extracellular matrix (ECM) proteins by myofibroblasts during chronic inflammatory responses, which can ultimately lead to organ failure and potentially death. Different states of macrophage activation…
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Journal Article
The Traditional Chinese Medicine Compound Hezi Qingyou Formula Controls the MAPK Signaling Pathway for Alleviating Gastric Ulcer Induced by Acetic Acid in Rats
In clinical practice, Hezi Qingyou Formula (HZQYF) has been observed to effectively alleviate clinical symptoms associated with gastri ulcers, though its precise mechanism of action remains unclear. To investigate the effects of HZQYF on gastric ulcers, we established a rat model of gastric ulcer…
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Journal Article
The Impact of Monkeypox Virus Infection on Pregnancy Outcome: Clinical Features and Potential Pathogenic Mechanisms
Monkeypox has garnered significant attention following its emergence in multiple countries and its designation as a global health emergency in 2022. There is a notable deficiency in clinical and experimental data regarding pregnancy outcomes following monkeypox infection. The complications…
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Journal Article
The Role of IFN-γ-Mediated Immune Cell Crosstalk in the Pathogenesis of Aplastic Anemia
Interferon-gamma (IFN-γ) is a central mediator of immune-driven bone marrow failure (BMF) in acquired aplastic anemia (AA). Persistent IFN-γ signaling alters the bone marrow microenvironment by activating the JAK–STAT1 pathway, which results in immunological imbalance, inflammatory amplification…
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Journal Article
Myeloid-Derived Suppressor Cells: Immunoregulatory Roles and Therapeutic Prospects in Immune-Mediated Hematological Disorders
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that have been increasingly defined and characterized over the past two decades, known for their remarkable capacity to expand and exert immunosuppressive effects in various pathological contexts, such…
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Journal Article
The Role of Neuro-Immune Regulation in the Pathogenesis of Psoriasis
Psoriasis is a chronic inflammatory skin disease characterized by abnormal proliferation of epidermal cells induced by an overactive immune system. In addition to the interaction between immune cells and keratinocytes, emerging research highlights the indispensable role of peripheral sensory…
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Journal Article
Proportion, Function, and Generation of Dual Receptor Lymphocytes
The specific immune response mechanisms of B cells and T cells are centered on the classic clonal selection theory, which posits that “a single lymphocyte expresses only one type of antigen receptor.” This mechanism is primarily achieved through V(D)J allelic exclusion rearrangement on germline…
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Journal Article
Intermittent Tacrolimus Treatment Delays CD8+ Tumor-Infiltrating Lymphocyte Exhaustion and Enhances PD1 Blockade Therapy in Melanoma-Bearing Mice
Continuous antigen exposure initiates the developmental process of CD8+ T cell exhaustion, accompanied by a gradual increase in the expression of inhibitory receptors (IRs). Our previous study conceptualized T cell exhaustion as an over-activation status induced by chronic antigen stimuli. To…
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Journal Article
Next-Generation Immune Checkpoints and Tumor Microenvironment Modulation in Cancer Immunotherapy
Trial Registration: ClinicalTrials.gov identifier: LAG-3 (NCT03470922, NCT04082364, NCT05064059, NCT05352672, NCT02614833, NCT03625323, NCT01968109), TIM-3 (NCT03307785, NCT03680508, NCT02608268, NCT02817633), TIGIT (NCT03563716), VISTA (NCT02671955, NCT02812875), IGSF8 (NCT05669430), CD73…
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Journal Article
Piplartine as an Innovative Natural Product With Dual Antiparasitic and Immunomodulatory Actions
Neglected tropical diseases (NTDs) remain a major global health burden, disproportionately affecting low- and middle-income regions and demanding innovative therapeutic strategies. This review summarizes current evidence on piplartine (piperlongumine), a naturally occurring amide from Piper species…
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